Abstract: Disclosed is a wound closure device, such as a suture, including a substantially flexible tensile member, the tensile member having an external surface, the external surface including a biocidal material such as a coating of substantially pure silver. A method of applying the suture includes piercing a patient's skin adjacent to a wound using, for example, a needle and drawing a substantially flexible tensile member through a resulting aperture in the skin. By virtue of the biocidal material, pathogens and other bioactive materials drawn through the aperture are rendered less active and/or incapable of causing infection.