Patents by Inventor Richard Edward Watts

Richard Edward Watts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
    Patent number: 11795580
    Abstract: The present disclosure relates to multifunctional verification molecules, including molecules according to formula (I): G-L-(B)K-Q-U, wherein G, L, B, K, Q, and U are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional verification molecules to remove defective multifunctional molecules and to quantify synthetic yield.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 24, 2023
    Assignee: Haystack Sciences Corporation
    Inventors: Richard Edward Watts, Divya Kanichar
  • OLIGONUCLEOTIDE DIRECTED AND RECORDED COMBINITORIAL SYNTHESIS OF ENCODED PROBE MOLECULES
    Publication number: 20220154179
    Abstract: The present disclosure relates to multifunctional molecules, including molecules according to formula (I): ([(B1)M-D-L1]Y—H1)O-G-(H2-[L2-E-(B2)K]W)P, ??(I) wherein G, H1, H2, D, E, B1, B2, M, K, L1, L2, O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.
    Type: Application
    Filed: October 26, 2021
    Publication date: May 19, 2022
    Applicant: Haystack Sciences Corporation
    Inventor: Richard Edward WATTS
  • METHODS AND SYSTEMS FOR PROCESSING OR ANALYZING OLIGONUCLEOTIDE ENCODED MOLECULES
    Publication number: 20220145362
    Abstract: The present disclosure provides methods and systems for determining a target-activity of at least one resolved oligonucleotide encoded molecule. In an embodiment, a method includes providing a separation medium, wherein the separation medium contains at least one target molecule; and various methods of separating a mixture of at least two oligonucleotide encoded molecules by electrophoresis based on different target-activities of the oligonucleotide encoded molecules for a target molecule. Benefits of the methods disclosed herein can include, without limitation, collecting and calculating qualitative and quantitative data for the target-activity of an encoded portion of the oligonucleotide encoded molecule for a target molecule.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 12, 2022
    Applicant: Haystack Sciences Corporation
    Inventors: Richard Edward WATTS, Divya KANICHAR, Patrick James MCENANEY
  • Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
    Patent number: 11186836
    Abstract: The present disclosure relates to multifunctional molecules, including molecules according to formula (I): ([(B1)M-D-L1]Y-H1)O-G-(H2-[L2-E-(B2)K]W)P, ??(I) wherein G, H1, H2, D, E, B1, B2, M, K, L1, L2, O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: November 30, 2021
    Assignee: Haystack Sciences Corporation
    Inventor: Richard Edward Watts
  • MOLECULES FOR VERIFYING OLIGONUCLEOTIDE DIRECTED COMBINATORIAL SYNTHESIS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20200332441
    Abstract: The present disclosure relates to multifunctional verification molecules, including molecules according to formula (I): G-L-(B)K-Q-U, wherein G, L, B, K, Q, and U are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional verification molecules to remove defective multifunctional molecules and to quantify synthetic yield.
    Type: Application
    Filed: May 1, 2018
    Publication date: October 22, 2020
    Inventors: Richard Edward Watts, Divya Kanichar
  • MULTINOMIAL ENCODING FOR OLIGONUCLEOTIDE-DIRECTED COMBINATORIAL CHEMISTRY
    Publication number: 20200263163
    Abstract: The present disclosure relates to multifunctional molecules, including molecules according to formula (I-A) [(B1)M-L1]O-G, and (I) [(B1)M-L1]O-G-[(L2-(B2)K]P wherein B1, M, L1, O, G, L2, B2, K, and P are defined herein, wherein each positional building block B1 is identified by from 1 to 5 coding regions in G, and from about 10% to 100% of the positional building blocks B1 at position M and/or B2 at position K, based on a total number of positional building blocks, are identified by a combination of from 2 to 5 independent coding regions. Methods of making such multifunctional molecules, and methods of serially enriching an oligonucleotide encoded library, are also disclosed. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.
    Type: Application
    Filed: September 24, 2018
    Publication date: August 20, 2020
    Applicant: Haystack Sciences Corporation
    Inventors: Richard Edward Watts, Divya Kanichar
  • OLIGONUCLEOTIDE DIRECTED AND RECORDED COMBINATORIAL SYNTHESIS OF ENCODED PROBE MOLECULES
    Publication number: 20190169607
    Abstract: The present disclosure relates to multifunctional molecules, including molecules according to formula (I): ([(B1)M-D-L1]Y-H1)O-G-(H2-[L2-E-(B2)K]W)P, ??(I) wherein G, H1, H2, D, E, B1, B2, M, K, L1, L2, O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.
    Type: Application
    Filed: June 8, 2017
    Publication date: June 6, 2019
    Inventor: Richard Edward WATTS
  • METHODS OF SYNTHESIS OF OLIGONUCLEOTIDE TAGGED COMBINATORIAL LIBRARIES AND USES THEREOF
    Publication number: 20150344872
    Abstract: Provided herein are methods of synthesis of a compound which includes a functional moiety operatively linked to a tagging oligonucleotide, libraries thereof and methods of using the compound and libraries thereof to identify compounds which bind to a target.
    Type: Application
    Filed: May 30, 2015
    Publication date: December 3, 2015
    Applicant: DICE Molecules SV, LLC
    Inventors: Pehr Harbury, Madan Paidhungat, Phillip Patten, Richard Edward Watts
  • Transglutaminase inhibitors and methods of use thereof
    Patent number: 8871718
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: October 28, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Kihang Choi
  • Transglutaminase inhibitors and methods of use thereof
    Patent number: 8470782
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: June 25, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Transglutaminase inhibitors and methods of use thereof
    Patent number: 8153593
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: April 10, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Richard Edward Watts
  • Transglutaminase inhibitors and methods of use thereof
    Publication number: 20090312272
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: August 4, 2009
    Publication date: December 17, 2009
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • Transglutaminase inhibitors and methods of use thereof
    Patent number: 7579313
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: August 25, 2009
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Washington University
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich
  • TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20090042806
    Abstract: Transglutaminase inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: August 28, 2006
    Publication date: February 12, 2009
    Inventors: Chaitan Khosla, Richard Edward Watts, Matthew John Siegel, Daniel M. Pinkas, Kihang Choi, Keith M. Rich