Patents by Inventor Richard Eric Mewshaw
Richard Eric Mewshaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7671084Abstract: This invention provides estrogen receptor modulators of formula I having the structure where R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification and the use of such compounds as estrogenic agents.Type: GrantFiled: October 31, 2006Date of Patent: March 2, 2010Assignee: WyethInventors: Richard Eric Mewshaw, Richard James Edsall, Jr.
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Patent number: 7632845Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, R4, R5, and R6 are as defined in the specification, or a N-oxide thereof or a pharmaceutically acceptable salt thereof or a prodrug thereof.Type: GrantFiled: May 31, 2006Date of Patent: December 15, 2009Assignee: WyethInventors: An Thien Vu, Stephen Todd Cohn, Richard Eric Mewshaw
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Publication number: 20090054454Abstract: Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.Type: ApplicationFiled: August 21, 2007Publication date: February 26, 2009Inventors: Aranapakam Mudumbai Venkatesan, Osvaldo Dos Santos, Magda Asselin, George Theodore Grosu, Deborah A. Evrard, Richard Eric Mewshaw, Kristin Meagher
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Patent number: 7279600Abstract: This invention provides estrogen receptor modulators having the structure: wherein R1 to R6 and R8 are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 29, 2004Date of Patent: October 9, 2007Assignee: WyethInventors: Richard Eric Mewshaw, Cuijian Yang
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Patent number: 7276603Abstract: Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.Type: GrantFiled: April 29, 2004Date of Patent: October 2, 2007Assignee: WyethInventors: Aranapakam Mudumbai Venkatesan, Osvaldo Dos Santos, Magda Asselin, George Theodore Grosu, Deborah A. Evrard, Richard Eric Mewshaw, Kristin Meagher
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Patent number: 7250440Abstract: This invention provides estrogen receptor modulators of formula I, having the structure where R1, R2, R3, and R4 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 9, 2004Date of Patent: July 31, 2007Assignee: WyethInventors: Richard Eric Mewshaw, Stephen Marc Bowen, Eric Steven Manas
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Patent number: 7157491Abstract: This invention provides estrogen receptor modulators having the structure where R1–R5 are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 13, 2004Date of Patent: January 2, 2007Assignee: WyethInventors: Richard Eric Mewshaw, Stephen Todd Cohn
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Patent number: 7157492Abstract: This invention provides estrogen receptor modulators of formula I, having the structure where R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification.Type: GrantFiled: February 23, 2005Date of Patent: January 2, 2007Assignee: WyethInventors: Richard Eric Mewshaw, Richard James Edsall, Jr.
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Patent number: 7084276Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, R4, R5, and R6 are as defined in the specification, or a N-oxide thereof or a pharmaceutically acceptable salt thereof or a prodrug thereof.Type: GrantFiled: May 13, 2004Date of Patent: August 1, 2006Assignee: WyethInventors: An Thien Vu, Stephen Todd Cohn, Richard Eric Mewshaw
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Patent number: 6667322Abstract: Compounds of the formula useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.Type: GrantFiled: October 4, 2002Date of Patent: December 23, 2003Assignee: WyethInventors: Jonathan Laird Gross, Richard Eric Mewshaw, Gary Paul Stack
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Publication number: 20030100579Abstract: Compounds of the formula 1Type: ApplicationFiled: October 4, 2002Publication date: May 29, 2003Applicant: WyethInventors: Jonathan Laird Gross, Richard Eric Mewshaw, Gary Paul Stack
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Patent number: 6127380Abstract: This invention relates to D.sub.2 dopaminergic compounds of the formula ##STR1## wherein: R.sup.1 is hydrogen, trifluoromethyl, pentafluoroethyl, heptafluoropropyl, straight-chain or branched alkyl group having up to 6 carbons or benzyl optionally substituted by one to three substituents selected from halogen, amino, nitro, hydroxy, and C.sub.1 -C.sub.6 alkoxy;R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.3 is hydrogen, straight-chain or branched alkyl group having up to 10 carbon atoms, cyclohexylmethyl, --(CH.sub.2).sub.m Ar where Ar is phenyl, naphthalenyl, thienyl, furanyl, or pyridinyl, each optionally substituted by one to two substituents selected from halogen, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl and C.sub.1 -C.sub.6 alkyl, and m is 1-3or NR.sup.2 R.sup.3 is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2-yl;Y is hydrogen, halogen, lower alkyl, amino, or lower alkoxy;n is 1-5:or a pharmaceutically acceptable salt thereof. These D.sub.Type: GrantFiled: February 17, 1998Date of Patent: October 3, 2000Assignee: American Home Products CorporationInventors: James Albert Nelson, Richard Eric Mewshaw
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Patent number: 6103744Abstract: Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.2 is selected from hydrogen, straight-chain and branched C.sub.1 -C.sub.10 alkyl, cyclohexylmethyl or --(CH.sub.2).sub.m Ar where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from C.sub.1 -C.sub.6 alkyl, halogen, C.sub.1 -C.sub.6 alkoxide and trifluoromethyl;or NR.sup.1 R.sup.2 is 1, 2, 3, 4-tetrahydroquinolin-1-yl or 1, 2, 3, 4-tetrahydroisoquinolin-2-yl;m is 1-5;n is 1 or 2;R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl;Y is halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;or a pharmaceutically acceptable salt thereof, which are dopamine autoreceptor agonists and as such are useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, alcohol addiction and drug addiction.Type: GrantFiled: September 10, 1999Date of Patent: August 15, 2000Assignee: American Home Products CorporationInventors: Richard Eric Mewshaw, James Albert Nelson, Uresh Shantilal Shah
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Patent number: 5990144Abstract: Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.2 is selected from hydrogen, straight-chain and branched C.sub.1 -C.sub.10 alkyl, cyclohexylmethyl or --(CH.sub.2).sub.m Ar where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from C.sub.1 -C.sub.6 alkyl, halogen, C.sub.1 -C.sub.6 alkoxy and trifluoromethyl;or NR.sup.1 R.sup.2 is 1, 2, 3, 4-tetrahydroquinolin-1-yl or 1, 2, 3, 4-tetrahydroisoquinolin-2-yl;m is 1-5;n is 1 or 2;R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl;Y is hydrogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;or a pharmaceutically acceptable salt thereof, which are dopamine autoreceptor agonists and as such are useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, alcohol addiction and drug addiction.Type: GrantFiled: February 17, 1998Date of Patent: November 23, 1999Assignee: American Home Products CorporationInventors: Richard Eric Mewshaw, James Albert Nelson, Uresh Shantilal Shah
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Patent number: 5972958Abstract: This invention relates to a novel series of compounds having potency at the dopamine D.sub.2 receptor which are illustrated by the following Formula I: ##STR1## wherein: R.sup.1 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sup.3 is selected from hydrogen, straight-chain and branched alkyl group having up to 10 carbon atoms, cyclohexylmethyl or --CH.sub.2).sub.m Ar where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from C.sub.1 -C.sub.6 alkyl, halogen, C.sub.1 -C.sub.6 alkoxide, trifluoromethyl, 4-fluorobutyrophenone;or NR.sup.2 R.sup.3 is 1, 2, 3, 4-tetrahydroquinolin-1-yl or 1, 2, 3, 4-tetrahydroisoquinolin-2-yl;m is 1-5;n is 1 or 2;Y is halogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 17, 1998Date of Patent: October 26, 1999Assignee: American Home Products CorporationInventors: James Albert Nelson, Richard Eric Mewshaw, Uresh Shantilal Shah
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Patent number: 5958965Abstract: Compounds of the formula: ##STR1## in which R.sub.1 is hydrogen, alkyl, cycloalkylalkyl, arylalkyl, (haloaryl)alkyl, (alkoxyaryl)alkyl, thienylmethyl, furanylmethyl, pyridinylmethyl, alkylphenyl, 4-fluorobutyrophenone or 6-fluoro-1,2-benzisoxazol-yl-propyl; X is hydrogen, halogen, cyano, alkyl, acetyl, trifluoroacetyl, trifluoromethyl or formyl; Y is hydrogen, halogen, alkoxy or alkyl; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analagous drugs and they also have affinity for the 5-HT.sub.1A receptors which characterizes them as useful in the treatment of diseases attending disturbances in the serotinergic systems, such as anxiety, stress, depression, sexual dysfunctions and sleep disturbances.Type: GrantFiled: August 12, 1997Date of Patent: September 28, 1999Assignee: American Home Products CorporationInventors: Richard Eric Mewshaw, Michael Byron Webb
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Patent number: 5922715Abstract: This invention relates to compounds of Formula I ##STR1## wherein: R.sup.1 and R.sup.2 are independently selected from hydrogen, straight-chain and branched alkyl group having up to 10 carbon atoms or --(CH.sub.2).sub.m Ar where Ar is phenyl, naphthyl or thienyl, each optionally substituted by one or two substituents selected independently from C.sub.1 -C.sub.6 alkyl, halogen, C.sub.1 -C.sub.6 alkoxide and trifluoromethyl;or NR.sup.1 R.sup.2 is 1, 2, 3, 4-tetrahydroquinolin-1-yl or 1, 2, 3, 4-tetrahydroisoquinoline-2-yl;m is 1-5;n is 1 or 2;Y is hydrogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;or the pharmaceutically acceptable salts thereof, which are dopamine D.sub.2 agonists and therefore useful in the treatment of psychoses and Parkinson's disease.Type: GrantFiled: February 17, 1998Date of Patent: July 13, 1999Assignee: American Home Products CorporationInventors: James Albert Nelson, Uresh Shantilal Shah, Richard Eric Mewshaw
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Patent number: 5872144Abstract: This invention relates to dopamine D.sub.2 agonists of the formula ##STR1## wherein: Y is hydrogen, halogen, or C.sub.1 -C.sub.6 alkoxy;R.sup.1 is hydrogen or C.sub.1 -C.sub.6 alkyl;X is methylene, oxygen or carbonyl;Ar is phenyl or thienyl, each optionally substituted with 1-2 groups independently selected from C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkyl, halogen, trifluoromethyl and phenyl;n=1-4,or pharmaceutically acceptable salts thereof. Dopamine D.sub.2 agonists are useful in the treatment of schizophrenia, Tourette's syndrome, drug and alcohol addiction, and also useful in the treatment of Parkinson's disease.Type: GrantFiled: February 17, 1998Date of Patent: February 16, 1999Assignee: American Home Products CorporationInventors: Richard Eric Mewshaw, Anthonie Johan Verwijs
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Patent number: 5817690Abstract: A compound of the formula I: ##STR1## in which Y is hydrogen, halogen or lower alkoxy; R.sub.1 is hydrogen, lower alkyl or aryl(lower)alkyl; R.sub.2 is hydrogen, lower alkyl or --(CH.sub.2).sub.n X.sub.p Ar, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thioxobenzimidazolyl; or R.sub.1 and R.sub.2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.Type: GrantFiled: August 12, 1997Date of Patent: October 6, 1998Assignee: American Home Products CorporationInventor: Richard Eric Mewshaw
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Patent number: 5760070Abstract: A compound of the formula I: ##STR1## in which Y is hydrogen, halogen or alkoxy; R is hydrogen or alkylthio; R.sub.1 is hydrogen or alkyl; X is hydrogen, halogen, alkoxy, alkyl or phenyl; n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.Type: GrantFiled: August 12, 1997Date of Patent: June 2, 1998Assignee: American Home Products CorporationInventors: Richard Eric Mewshaw, Michael Byron Webb