Patents by Inventor Richard Eric Rothman

Richard Eric Rothman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantitative assay for the simultaneous detection and speciation of bacterial infections
    Publication number: 20040235010
    Abstract: An adaptation of the real-time PCR assay allows for highly sensitive detection of any eubacterial species with simultaneous speciation. The assay relies on a ‘multiprobe’ design in which a single set of highly conserved sequences encoded by the 16S rRNA gene serves as the primer pair, and it is used in combination with both an internal highly conserved sequence, the universal probe, and an internal variable region, the species-specific probe. A pre-PCR ultrafiltration step can be used to effectively decontaminate or remove background DNA. The real-time system reliably identifies 14 common bacterial species with a detection limit of 50 fg.
    Type: Application
    Filed: December 23, 2003
    Publication date: November 25, 2004
    Applicant: The Johns Hopkins University
    Inventors: Richard Eric Rothman, Samuel Yang, Shin Lin, Gabor David Kelen
  • Quantitative assay for the simultaneous detection and speciation of bacterial infections
    Patent number: 6699670
    Abstract: An adaptation of the real-time PCR assay allows for highly sensitive detection of any eubacterial species with simultaneous speciation. The assay relies on a ‘multiprobe’ design in which a single set of highly conserved sequences encoded by the 16S rRNA gene serves as the primer pair, and it is used in combination with both an internal highly conserved sequence, the universal probe, and an internal variable region, the species-specific probe. A pre-PCR ultrafiltration step can be used to effectively decontaminate or remove background DNA. The real-time system reliably identifies 14 common bacterial species with a detection limit of 50 fg.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: March 2, 2004
    Assignee: The Johns Hopkins University
    Inventors: Richard Eric Rothman, Samuel Yang, Shin Lin, Gabor David Kelen
  • Quantitative assay for the simultaneous detection and speciation of bacterial infections
    Publication number: 20030124545
    Abstract: An adaptation of the real-time PCR assay allows for highly sensitive detection of any eubacterial species with simultaneous speciation. The assay relies on a ‘multiprobe’ design in which a single set of highly conserved sequences encoded by the 16S rRNA gene serves as the primer pair, and it is used in combination with both an internal highly conserved sequence, the universal probe, and an internal variable region, the species-specific probe. A pre-PCR ultrafiltration step can be used to effectively decontaminate or remove background DNA. The real-time system reliably identifies 14 common bacterial species with a detection limit of 50 fg.
    Type: Application
    Filed: March 1, 2002
    Publication date: July 3, 2003
    Inventors: Richard Eric Rothman, Samuel Yang, Shin Lin, Gabor David Kelen