Patents by Inventor Richard F. Labaudiniere

Richard F. Labaudiniere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROARYL DIAMIDE IRE1/XBP1s ACTIVATORS
    Publication number: 20240092757
    Abstract: Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.
    Type: Application
    Filed: November 8, 2023
    Publication date: March 21, 2024
    Inventors: Richard F. Labaudiniere, Bradley Dean Tait, Hank Michael James Petrassi, Jeffery W. Kelly, R. Luke Wiseman, Kyunga Lee, Adrian Marco Guerrero
  • SPIROCYCLIC IMIDAZOLIDINONES AND IMIDAZOLIDINEDIONES FOR TREATMENT OF LIGHT CHAIN AMYLOIDOSIS
    Publication number: 20240051960
    Abstract: Provided herein are compounds that stabilize immunoglobulin light chains, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject with light chain amyloidosis.
    Type: Application
    Filed: October 11, 2023
    Publication date: February 15, 2024
    Inventors: Richard F. Labaudiniere, Bradley Dean Tait, Hank Michael James Petrassi
  • COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING
    Publication number: 20230287021
    Abstract: Provided herein are compounds having activity against TTR related conditions, and pharmaceutically accepted salts and solvates thereof. Also provided are methods of using the compounds for inhibiting and preventing TTR aggregation and/or amyloid formation in the peripheral nerves, kidney, cardiac tissue, eye and CNS, and of treating a subject with peripheral TTR amyloidosis.
    Type: Application
    Filed: January 27, 2021
    Publication date: September 14, 2023
    Inventors: Bradley Dean Tait, Richard F. Labaudiniere, Joseph Salvino
  • USE OF RAMOPLANIN TO TREAT DISEASES ASSOCIATED WITH THE USE OF ANTIBIOTICS
    Publication number: 20100112091
    Abstract: The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and for a duration effective to treat said disease. The disease may be caused, for example, by the presence of a bacterium such as enterotoxin producing strains of C. difficile, C. perfringens, or S. aureus.
    Type: Application
    Filed: September 10, 2009
    Publication date: May 6, 2010
    Inventors: Daniela Jabes, Timothy S. Leach, Richard F. Labaudiniere, Steven M. Rauscher, Giorgio Mosconi
  • Use of ramoplanin to treat diseases associated with the use of antibiotics
    Publication number: 20080113902
    Abstract: The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and for a duration effective to treat said disease. The disease may be caused, for example, by the presence of a bacterium such as enterotoxin producing strains of C. difficile, C. perfringens, or S. aureus.
    Type: Application
    Filed: October 3, 2007
    Publication date: May 15, 2008
    Applicant: Oscient Pharmaceuticals Corporation
    Inventors: Daniela Jabes, Timothy S. Leach, Richard F. Labaudiniere, Steven M. Rauscher, Giorgio Mosconi
  • Use of ramoplanin to treat diseases associated with the use of antibiotics
    Patent number: 7317001
    Abstract: The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and for a duration effective to treat said disease. The disease may be caused, for example, by the presence of a bacterium such as enterotoxin producing strains of C. difficile, C. perfringens, or S. aureus.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: January 8, 2008
    Assignee: Oscient Pharmaceuticals Corporation
    Inventors: Daniela Jabes, Timothy S. Leach, Richard F. Labaudiniere, Steven M. Rauscher, Giorgio Mosconi
  • Therapeutic uses of tri-aryl acid derivatives
    Patent number: 7005440
    Abstract: The use of triaryl acid derivatives of formula (I) and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 28, 2006
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Zaid Jayyosi, Gerard M. McGeehan, Michael F. Kelley, Richard F. Labaudiniere, Litao Zhang, Robert D. Groneberg, Daniel G. McGarry, Thomas J. Caulfield, Anne Minnich, Mark Bobko, Robert Morris
  • Use of ramoplanin to treat diseases associated with the use of antibiotics
    Publication number: 20040072732
    Abstract: The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and for a duration effective to treat said disease. The disease may be caused, for example, by the presence of a bacterium such as enterotoxin producing strains of C. difficile, C. perfringens, or S. aureus.
    Type: Application
    Filed: June 5, 2003
    Publication date: April 15, 2004
    Inventors: Daniela Jabes, Timothy S. Leach, Richard F. Labaudiniere, Steven M. Rauscher
  • Luciferase reporter bioassay of parathyroid hormone compounds
    Patent number: 6720153
    Abstract: This invention is directed to a bioassay for determining the functionality of parathyroid hormone compounds. More particularly, this invention is directed to a bioassay wherein the compound to be tested is added to a culture of parathyroid hormone receptor expressing cells bearing a reporter gene under the transcriptional control of multiple c-AMP responsive elements.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: April 13, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Richard F. Labaudiniere, Kin T. Yu, Gregg R. Crumley, Clarence C. Morse
  • Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;,&bgr;-unsaturated carboxylic acid and aldehyde compounds
    Patent number: 6710208
    Abstract: This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;,&bgr;-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: March 23, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Joseph M. Salvino, George C. Morton, Helen J. Mason, Richard F. Labaudiniere
  • Fluorophenyl resin compounds
    Patent number: 6639023
    Abstract: This invention is directed to a fluorophenyl resin compound, to methods of its preparation; and to its use in the solid phase synthesis of amides, peptides, hydroxamic acids, amines, urethanes, carbonates carbamates, sulfonamides and &agr;-substituted carbonyl compounds.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: October 28, 2003
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Joseph M. Salvino, Robert D. Groneberg, John E. Airey, Gregory B. Poli, Gerard M. McGeehan, Richard F. Labaudiniere, François-Frédéric Clerc, Daniel Noël André Bezard
  • Therapeutic uses of di-aryl acid derivatives
    Patent number: 6635655
    Abstract: The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: October 21, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Zaid Jayyosi, Gerard M. McGeehan, Michael F. Kelley, Richard F. Labaudiniere, Litao Zhang, Robert D. Groneberg, Daniel G. McGarry, Thomas J. Caulfield, Anne Minnich, Mark Bobko
  • Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds
    Patent number: 6492553
    Abstract: A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: December 10, 2002
    Assignee: Aventis Pharamaceuticals Inc.
    Inventors: Christopher Hulme, George C. Morton, Joseph M. Salvino, Richard F. Labaudiniere, Helen J. Mason, Matthew M. Morrissette, Liang Ma, Marie-Pierre Cherrier
  • Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha, beta-unsaturated carboxylic acid and aldehyde compounds
    Publication number: 20020183558
    Abstract: This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and (&agr;,&bgr;-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.
    Type: Application
    Filed: March 27, 2002
    Publication date: December 5, 2002
    Inventors: Joseph M. Salvino, George C. Morton, Helen J. Mason, Richard F. Labaudiniere
  • Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;&bgr;-unsaturated carboxylic acid and aldehyde compounds
    Patent number: 6392010
    Abstract: This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;,&bgr;-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: May 21, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Joseph M. Salvino, George C. Morton, Helen J. Mason, Richard F. Labaudiniere
  • Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and .alpha..beta.-unsaturated carboxylic acid and aldehyde compounds
    Patent number: 6133409
    Abstract: This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and .alpha.,.beta.-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: October 17, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Joseph M. Salvino, George C. Morton, Helen J. Mason, Richard F. Labaudiniere
  • Functionalized resin for the synthesis of amides and peptides
    Patent number: 6127515
    Abstract: This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR.sup.1 ; and R.sup.1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: October 3, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Franco Manfre, Benoit J. Vanasse, Richard F. Labaudiniere, George C. Morton
  • Therapeutic uses of di-aryl acid derivatives
    Patent number: RE40558
    Abstract: The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: October 28, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Zaid Jayyosi, Gerard M. McGeehan, Michael F. Kelley, Richard F. Labaudiniere, Litao Zhang, Robert D. Groneberg, Daniel G. McGarry, Thomas J. Caulfield, Anne Minnich, Mark Bobko