Abstract: The present invention provides peptides and pharmacologically active compounds including gonadotropin-releasing hormone (GnRH) analogues according to formulas of the invention, wherein the compounds show an antitumor effect. The invention additionally provides compositions including these peptides and compounds.

Abstract: A first race component includes a flat, circular raceway portion, defined about an axis, and an axially extending lip portion. A plurality of needle rollers is arranged radially with respect to the axis for rolling contact with the flat raceway. A bearing cage retains the needle rollers and is engageable with the lip portion of the first component for piloting of the bearing cage. A second race component, made of different material, includes a flat portion in contact with the raceway portion of the first race component and a lip portion extending axially and radially from the flat portion and beyond the lip portion of the first race component such that the second race component is engageable by the bearing cage to hold the first race component, the second race component and the bearing cage together as an assembly.

Abstract: A needle bearing cup includes an inner bearing cup having an inner surface which forms a rolling element raceway and an outer bearing cup disposed about the periphery of the inner bearing cup having a length greater than a length of the inner bearing cup to form a lip. The lip of the outer bearing cup is then formed to retain rolling elements within the inner bearing cup. Preferably, the rolling elements are needle rollers and the inner bearing cup is secured to an outer bearing cup by mechanical lock in the form of a protruding portion extending from the outer bearing cup. The bearing cup may be double drawn with first and second sheet metal blanks forming the inner and outer bearing cups.

Abstract: A browser interface for providing financial services is provided. The interface comprise a toolbar; a task menu wherein each task is associated with a number of financial applications; an object menu associated with each task which provides a link to each financial application; and an action menu for presenting one or more actions specific to a user-selected financial application. The task menu is always present on the browser interface and the object and action menus vary depending upon the options selected. The financial applications include market monitoring functions, portfolio reviews, model balancing, and automated trading.

Abstract: A needle bearing cup includes an inner bearing cup having an inner surface which forms a rolling element raceway and an outer bearing cup disposed about the periphery of the inner bearing cup having a length greater than a length of the inner bearing cup to form a lip. The lip of the outer bearing cup is then formed to retain rolling elements within the inner bearing cup. Preferably, the rolling elements are needle rollers and the inner bearing cup is secured to an outer bearing cup by mechanical lock in the form of a protruding portion extending from the outer bearing cup. The bearing cup may be double drawn with first and second sheet metal blanks forming the inner and outer bearing cups.

Abstract: A self-lubricating plastic center plate assembly bearing liner for placement between a body bolster center plate and a truck bolster center plate of a center plate assembly in a railroad car, wherein the liner is configured to substantially mate with the center plates and includes a body having an integrally formed electrically conductive ring of plastic material which provides electrical continuity between the plates in the center plate assembly.

Abstract: A shaft is mounted on side walls of a rocker arm, extending through a central cavity of the rocker arm. A bearing is located within the cavity of the rocker arm, positioned over the shaft. A yoke member adapted for mounting on the internal combustion engine has a curved portion enclosing a portion of the outer circumference of the bearing such that the bearing supports the rocker arm when the yoke mount rocker arm assembly is mounted on the internal combustion engine.

Abstract: A self-lubricating plastic center plate assembly bearing liner for placement between a body bolster center plate and a truck bolster center plate of a center plate assembly in a railroad car, wherein the liner is configured to substantially mate with the center plates and includes a body having an integrally formed electrically conductive ring of plastic material which provides electrical continuity between the plates in the center plate assembly.

Abstract: A gap closing device for closing the air gaps between the sidewall panels and the floor and/or the gaps between the sidewall panels and auxiliary floor panels or plates in an auto rack railroad car comprising an elongated strip of flexible extruded plastic material having a spine adapted to extend through the gap, a flap centrally connected to one end of the spine for closing the gap, and fins extending from the spine to lock the device in gap closing position. The fins may include a plurality of locking and/or pressure fins.

Abstract: A brake beam wear plate for mounting in brake beam guide brackets of railroad car truck side frames having side walls of varying thicknesses to define a slideway for the brake beam lugs providing a sloppy fit and a path of movement to obtain the ideal clasping angle and alignment for the brake shoes with the wheels, and thereby produce better train handling during braking, and uniform wearing of the shoes to enhance shoe life and reduce maintenance.

Abstract: A coupler carrier wear plate for a long-shank coupler which includes a mild steel base plate weldable to the carrier, a manganese steel wear plate engageably supporting the coupler shank and connected to the base plate by a resilient bonding material. The bonding material is of a thickness to accommodate flatness variations encountered on a coupler carrier.

Abstract: Described is a system for measuring noxious gas concentration in an affected space and for controlling the device producing the noxious gas or for decreasing the concentration of the gas in the affected space. The invention is particularly described in relation to measuring carbon monoxide concentration in an automobile garage and for controlling the garage door opener circuit to open the garage door in response to a preselected concentration of carbon monoxide. Also described in particular is a system for deactivating a furnace operating circuit to turn off the furnace in the event of excessive carbon monoxide concentration.

Abstract: A drawn cup bearing has a tapered inside surface which was shaped by a tapered punch.

Abstract: A gap sealer for covering the gaps between horizontally extending and vertically spaced apart sidewall panels on auto rack railroad cars and between sidewall panels and the floor, roof or vertical posts. The gap sealer is a single piece of extruded plastic having a head attachable to a flange of a sidewall panel and a tail or flap biasing against the flange of a vertically adjacent sidewall panel, the floor, roof or post, such that the body of the gap sealer covers the gap to prevent air passage. The gap sealer may also include a bumper which protects vehicle doors from contacting the sidewall panels and risking damage. An individual bumper may also be used to protect vehicle doors, and be attached to a sidewall panel by a unique fastener.

Abstract: A double-walled bearing cup has an inner cup portion and an outer cup portion fixed over the inner cup portion. Abutment portions of the bearing cup are engageable with a retaining washer, which is positioned within the bearing cup and adapted to be fixed over a shaft, to limit axial movement of the bearing cup relative to the shaft. Rolling members positioned within the bearing cup are engageable directly with the shaft such that the bearing cup may freely rotate with respect to the shaft. The bearing cup may have an open, closed, or tapered end to facilitate use of the bearing assembly in various applications.

Abstract: A bearing support member has two support arms extending in opposite directions along an axis and is adapted for mounting about a stud means. A bearing cup is fixed to the rocker arm, extending over each support arm. Rolling members are provided within an annulus formed between the support member and the bearing cups such that the rocker arm is free to oscillate rotatably with respect to the bearing support member. The bearing cups have a bottom surface forming an interference fit, axially, with an end surface of the bearing support member such that a preload is applied to the bearing support arm to reduce and control axial play. A protrusion and cutouts facilitating the preload and a method of assembly are also disclosed.

Abstract: Two support arms of a bearing support member extend in opposite directions, each support arm having an overlying bearing cup engageable with the rocker arm. Rolling members within an annulus formed between the bearing support member and the bearing cups provide free rotary oscillation of the rocker arm with respect to the bearing support member. At least one support arm has a crowned surface such that radial load is distributed along the length of the rolling members when misalignment of elements of the rocker arm assembly occurs. A bearing assembly for mounting within a rocker arm is also disclosed.

Abstract: Two bearing cups are rigidly mounted on side portions of a rocker arm and extend over respective arms of a bearing support member. Rolling members within an annulus formed between the bearing cups and the bearing support member permit the rocker arm to oscillate rotatably with respect to the bearing support member. Each bearing cup has a stepped bottom surface with a first bottom portion engageable with ends of the rolling members to limit axial movement of the rolling members and a second bottom portion, offset axially with respect to the first bottom portion, engageable with stop surfaces to limit axial movement of the rocker arm with respect to the support member. A bearing assembly for mounting within a rocker arm is also disclosed.

Abstract: A bearing assembly is mounted on an eccentric sleeve having a bore for receiving a rotatable shaft. After the bearing assembly is mounted on the eccentric sleeve, a counterweight lobe is mounted on the eccentric sleeve, abutting the bearing assembly, to control dynamic balance of the bearing and sleeve assembly and to restrain movement of the bearing assembly along the axis of the bore. The eccentric sleeve and counterweight lobe are keyed together to prevent relative rotation therebetween.

Abstract: A gap sealer for covering the gaps between horizontally extending and vertically spaced apart sidewall panels on auto rack railroad cars and between sidewall panels and the floor, roof or vertical posts. The gap sealer is a single piece of extruded plastic having a head attachable to a flange of a sidewall panel and a tail or flap biasing against the flange of a vertically adjacent sidewall panel, the floor, roof or post, such that the body of the gap sealer covers the gap to prevent air passage. The gap sealer may also include a bumper which protects vehicle doors from contacting the sidewall panels and risking damage. An individual bumper may also be used to protect vehicle doors, and be attached to a sidewall panel by a unique fastener.