Patents by Inventor Richard Fahrner

Richard Fahrner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE
    Publication number: 20230026836
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Application
    Filed: January 18, 2022
    Publication date: January 26, 2023
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • Methods and compositions for CNS delivery of iduronate-2-sulfatase
    Patent number: 11260112
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: March 1, 2022
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • Pharmaceutical compositions containing toxoids A and B
    Patent number: 10639362
    Abstract: This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: May 5, 2020
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: C. Russell Middaugh, Richard Fahrner, Peter Ciarametaro
  • METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE
    Publication number: 20200046810
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Application
    Filed: July 18, 2019
    Publication date: February 13, 2020
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • PHARMACEUTICAL COMPOSITIONS CONTAINING CLOSTRIDIUM DIFFICILE TOXOIDS A AND B
    Publication number: 20180000920
    Abstract: This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
    Type: Application
    Filed: June 26, 2017
    Publication date: January 4, 2018
    Applicant: Sanofi Pasteur Biologics, LLC
    Inventors: C. Russell MIDDAUGH, Richard FAHRNER, Peter CIARAMETARO
  • Pharmaceutical compositions containing toxoids A and B
    Patent number: 9687541
    Abstract: This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: June 27, 2017
    Assignee: Sanofi Pastuer Biologies, LLC
    Inventors: C. Russell Middaugh, Richard Fahrner, Peter Ciarametaro
  • PHARMACEUTICAL COMPOSITIONS CONTAINING CLOSTRIDIUM DIFFICILE TOXOIDS A AND B
    Publication number: 20160317640
    Abstract: This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
    Type: Application
    Filed: March 29, 2016
    Publication date: November 3, 2016
    Inventors: C. Russell MIDDAUGH, Richard FAHRNER, Peter CIARAMETARO
  • METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE
    Publication number: 20160158324
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Application
    Filed: November 11, 2015
    Publication date: June 9, 2016
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • Pharmaceutical compositions containing toxoids A and B
    Patent number: 9320790
    Abstract: This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: April 26, 2016
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: C. Russell Middaugh, Richard Fahrner, Peter Ciarametaro
  • Pharmaceutical Compositions Containing Clostridium Difficile Toxoids A and B
    Publication number: 20110045025
    Abstract: This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
    Type: Application
    Filed: September 15, 2008
    Publication date: February 24, 2011
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Russell C. Middaugh, Richard Fahrner, Peter Ciarametaro
  • Liposomal formulations
    Publication number: 20040156888
    Abstract: The invention provides a formulation comprising a lipophobic therapeutic agent encapsulated in a liposome having improved efficacy and/or reduced toxicity.
    Type: Application
    Filed: November 26, 2003
    Publication date: August 12, 2004
    Inventors: Gerard M. Jensen, Ning Hu, Su-Ming Chiang, Craig Skenes, Richard Fahrner