Abstract: An impeller is usable in a variable diameter bioreactor having multiple vessel sections of successively increasing or decreasing volume. The impeller includes an impeller blade extending along an impeller blade axis between first and second axial ends and having opposed impeller blade faces, an impeller blade leading edge, and an impeller blade trailing edge. Each of the leading and trailing edges defines a helix or spiral between the axial ends of the impeller blade. In certain arrangements, the impeller blade is one of at least two impeller blades joined together along an impeller shaft extending axially along the impeller blade axis mentioned, and the helix or spiral has a pitch approximately equal to one half of a length between the first and second axial ends.

Abstract: An impeller is usable in a variable diameter bioreactor having multiple vessel sections of successively increasing or decreasing volume. The impeller includes an impeller blade extending along an impeller blade axis between first and second axial ends and having opposed impeller blade faces, an impeller blade leading edge, and an impeller blade trailing edge. Each of the leading and trailing edges defines a helix or spiral between the axial ends of the impeller blade. In certain arrangements, the impeller blade is one of at least two impeller blades joined together along an impeller shaft extending axially along the impeller blade axis mentioned, and the helix or spiral has a pitch approximately equal to one half of a length between the first and second axial ends.

Abstract: A dispenser for dispensing a predetermined amount of material from a prefilled syringe. The dispenser includes a dispenser body and a plunger. The dispenser body includes a syringe mounting region and a nozzle portion through which the material is dispensed. The nozzle portion has a syringe dispensing end receiving cavity configured to mate with the dispensing end of the syringe and an outlet. A fluid flow path fluidly communicates the syringe dispensing end receiving cavity with the outlet and includes a measuring cavity having a predetermined volume. The plunger is carried by the dispenser body. The plunger has a retracted state in which the plunger is retracted from the measuring cavity such that the outlet is in fluid communication with the syringe dispensing end receiving cavity. The plunger has a depressed state in which the plunger extends through the measuring cavity to evacuate material from the measuring cavity.

Abstract: A dispenser for dispensing a predetermined amount of material from a prefilled syringe is provided. The dispenser includes a dispenser body and a plunger. The dispenser body includes a syringe mounting region and a nozzle portion through which the material is dispensed. The nozzle portion has a syringe dispensing end receiving cavity configured to mate with the dispensing end of the syringe and an outlet. A fluid flow path fluidly communicates the syringe dispensing end receiving cavity with the outlet and includes a measuring cavity having a predetermined volume. The plunger is carried by the dispenser body. The plunger has a retracted state in which the plunger is retracted from the measuring cavity such that the outlet is in fluid communication with the syringe dispensing end receiving cavity. The plunger has a depressed state in which the plunger extends through the measuring cavity to evacuate material from the measuring cavity.

Abstract: A driver for engaging and dispensing fluid from a sealed, prefilled syringe is provided. The driver includes a body and a rotating actuator configured to engage a plunger of the prefilled syringe. The driver is configured such that rotation of the rotating actuator relative to the body imparts both rotational movement and axial movement to a plunger of the prefilled syringe resulting in ejection of fluid from the prefilled syringe.

Abstract: Color processing methods and apparatus are provided that blend the gray component replacement (“GCR”) level of arbitrarily-specified input color data with an estimate of the GCR level of an output profile, and then converts processed device-independent data to output CMYK data that has a GCR level that substantially matches the GCR level of the input CMYK data. Methods and apparatus in accordance with this invention may be used to receive CMYK data that approximates a spot color, and provide tints of spot colors using an output profile that has a GCR level that differs from the GCR level of the input color data.

Abstract: Methods and apparatus are provided for electronically trapping a selected digital color image pixel. A plurality of pixels that surround the selected pixel are identified, a colorant value of each of the surrounding pixels is compared with a corresponding colorant value of the selected pixel, one of the surrounding pixels is identified to control trapping of the selected pixel, and the selected pixel is trapped based on a relationship between a colorant value of the selected pixel and a corresponding colorant value of the identified controlling pixel.

Abstract: A spot color pattern system provides a naming convention that allows the user to name a custom spot color pattern. A Raster Image Processing (RIP) has a database of spot color patterns that are user definable and are patterns which are images of a textile, fabric, metal, etc., that are repeatedly printed across the job. The RIP interprets a spot color pattern name in print job, looks up the spot color in its database, pulls up the image associated with the spot color pattern name, adds Postscript® pattern code to the print job to paint the spot color across the background of the print job, realistically simulating the final print media, and adds other code to perform other tasks, such as mirroring or four-way mirroring to prevent stitches from appearing. A RIP user interface gives the user the ability to create, modify, or delete spot color patterns. The invention also provides a mechanism that allows an application program to access a custom spot color pattern from the RIP.

Abstract: Color conversion apparatus and methods are provided for converting a first color value, such as an RGB, L*a*b* or XYZ color value, to a second color value, such as an RGB, CMY, CMKY, L*a*b*, L,C1C2, or XYZ color value, without saturation error.

Abstract: Color processing methods and apparatus are provided that blend the gray component replacement (“GCR”) level of arbitrarily-specified input color data with an estimate of the GCR level of an output profile, and then converts processed device-independent data to output CMYK data that has a GCR level that substantially matches the GCR level of the input CMYK data. Methods and apparatus in accordance with this invention may be used to receive CMYK data that approximates a spot color, and provide tints of spot colors using an output profile that has a GCR level that differs from the GCR level of the input color data.

Abstract: Apparatus and methods for simultaneously testing molten metal, such as steel, for concentration of three or more dissolved gases. A gas flow manifold allows multiple calibrations of a gas analysis device independently of operations such as immersion and purging of an immersible probe that can be provided with a bypass conduit for gas flow directly to the analysis device. Accurate nitrogen content is determined by oxidizing a retrieved gas sample using heated CuO and measuring gas concentration of the gas before and after such oxidation. A gas reservoir can be used to temporarily store a portion of the retrieved gas for use in such testing.

Abstract: A pharmaceutical composition comprises multiparticulates comprising a drug, a matrix material, and swelling agent. In one aspect, the multiparticulates comprise a core comprising a drug, and a coating surrounding the core. The coating is selected from the group consisting of (i) a water-permeable, substantially drug-impermeable coating, and (ii) an anti-enteric coating.

Abstract: Color conversion apparatus and methods are provided for converting a first color value, such as an RGB, L*a*b* or XYZ color value, to a second color value, such as an RGB, CMY, CMKY, L*a*b*, L, C1C2, or XYZ color value, without saturation error.

Abstract: Color conversion apparatus and methods are provided for converting a first color value, such as an RGB, L*a*b* or XYZ color value, to a second color value, such as an RGB, CMY, CMKY, L*a*b*, L, C1C2, or XYZ color value, without saturation error.

Abstract: Methods and apparatus are provided for electronically trapping a selected digital color image pixel. A plurality of pixels that surround the selected pixel are identified, a colorant value of each of the surrounding pixels is compared with a corresponding colorant value of the selected pixel, one of the surrounding pixels is identified to control trapping of the selected pixel, and the selected pixel is trapped based on a relationship between a colorant value of the selected pixel and a corresponding colorant value of the identified controlling pixel.

Abstract: Color conversion apparatus and methods are provided for converting a first color value, such as an RGB, L*a*b* or XYZ color value, to a second color value, such as an RGB, CMY, CMKY, L*a*b*, L,C1C2, or XYZ color value, without saturation error.

Abstract: Color conversion apparatus and methods are provided for converting a first color value, such as an RGB, L*a*b* or XYZ color value, to a second color value, such as an RGB, CMY, CMKY, L*a*b*, L,C1C2, or XYZ color value, without saturation error.

Abstract: Color conversion apparatus and methods are provided for converting a first color value, such as an RGB, L*a*b* or XYZ color value, to a second color value, such as an RGB, CMY, CMKY, L*a*b*, L,C1C2, or XYZ color value, without saturation error.

Abstract: A spot color pattern system provides a naming convention that allows the user to name a custom spot color pattern. A Raster Image Processing (RIP) has a database of spot color patterns that are user definable and are patterns which are images of a textile, fabric, metal, etc., that are repeatedly printed across the job. The RIP interprets a spot color pattern name in print job, looks up the spot color in its database, pulls up the image associated with the spot color pattern name, adds Postscript® pattern code to the print job to paint the spot color across the background of the print job, realistically simulating the final print media, and adds other code to perform other tasks, such as mirroring or four-way mirroring to prevent stitches from appearing. A RIP user interface gives the user the ability to create, modify, or delete spot color patterns. The invention also provides a mechanism that allows an application program to access a custom spot color pattern from the RIP.