Abstract: Provided herein are methods and systems for synthesizing polynucleotides using a solid support and a template array. Also provided herein are methods of selecting templates for the array.

Abstract: A heater for a vaporizer with air preheating element includes a casing, a tunnel with a perforated bottom, which is a cylindrical heating chamber for placing a cigarette, a heating element of a resistive type, a heat exchanger, including air channels for circulation and preheating of air by a heater, a top end and a bottom end, an air intake hole made in the top end. Outlet holes are communicated with exits of air channels of the heat exchanger for intake of air preheated by the heater in the tunnel. The casing is made in the form of a tape of a thin-film dielectric heat-resistant material, on which a thin layer of resistive material with contacts is applied on the end of one side, forming the heating element, and on the other side a top and bottom spacers are fixed and inclined toward the middle, as well as the edging, which are made of flexible heat-resistant material.

Abstract: A heater for a vaporizer with air preheating element includes a casing, a tunnel with a perforated bottom, which is a cylindrical heating chamber for placing a cigarette, a heating element of a resistive type, a heat exchanger, including air channels for circulation and preheating of air by a heater, a top end and a bottom end, an air intake hole made in the top end. Outlet holes are communicated with exits of air channels of the heat exchanger for intake of air preheated by the heater in the tunnel. The casing is made in the form of a tape of a thin-film dielectric heat-resistant material, on which a thin layer of resistive material with contacts is applied on the end of one side, forming the heating element, and on the other side a top and bottom spacers are fixed and inclined toward the middle, as well as the edging, which are made of flexible heat-resistant material.

Abstract: A nonaqueous, extrudable composition includes at least one thermoplastic polymer in an amount of more than 20 wt % of the whole composition and tobacco. A smokeless tobacco product in the form of a sheet can be made by extruding or hot melt shaping a nonaqueous composition comprising at least one thermoplastic polymer and tobacco, the sheet being soluble in a user's mouth and resulting in sustained release of nicotine to the user. The sheet can be in a form that may be placed in the buccal cavity of, on the palate of or sublingually in the user, and have an average dissolution time of 5 to 50 minutes for delivering super bioavailable nicotine to the user.

Abstract: A watch able to be used as a cryptographic system to encrypt plaintext to ciphertext or decrypt ciphertext to plaintext includes a watch face and a plurality of concentric rings. Each of the plurality of concentric rings is rotatable with respect to the watch face and includes a number of symbols, the number of symbols corresponding to the number of hours represented on the watch face, at least some of the symbols corresponding to letters of an alphabet, characters in a writing system and/or numbers. At least one of the plurality of concentric rings is rotatable in a direction opposite to a direction of at least one other of the plurality of concentric rings.

Abstract: A watch able to be used as a cryptographic system to encrypt plaintext to ciphertext or decrypt ciphertext to plaintext includes a watch face and a plurality of concentric rings. Each of the plurality of concentric rings is rotatable with respect to the watch face and includes a number of symbols, the number of symbols corresponding to the number of hours represented on the watch face, at least some of the symbols corresponding to letters of an alphabet, characters in a writing system and/or numbers. At least one of the plurality of concentric rings is rotatable in a direction opposite to a direction of at least one other of the plurality of concentric rings.

Abstract: The use of methylnaltrexone bromide in combination and in one dosage unit, with any opioid drug in order to prevent the constipation which can be associated with opioids.

Abstract: A system for providing an indication indicative of whether or not a seat belt of a vehicle occupant is fastened includes a seat belt system including a seat belt and a visible marking provided on the seat belt, the marking being visible from outside the vehicle when the seat belt is fastened. Alternatively, the system includes a seat restraint system including a seat restraint system for a passenger including a seat restraint having a locked position for restraining the passenger in a seat, a sensor for sensing whether or not the seat restraint system is in the locked position, and an indicator responsive to the sensor, the indicator being accessible from outside the vehicle or at a location remote from the passenger, for displaying an indication indicative of whether or not the seat restraint system is in the locked position.

Abstract: The present invention relates to packaged oral delivery systems for delivery of actives into the oral cavity. In particular, the packaged pharmaceutical product contains a complexate including a complexing agent and an active, an oral delivery system for delivery of the complexate and a package for containing the oral delivery system. The package includes indicia associated therewith. The indicia identifies the complexate as the active ingredient contained in the oral delivery system, which is as a regulatory approvable chemical entity. The present invention also relates to methods of labeling, pricing, marketing and satisfying governmental regulations for such packaged pharmaceutical products.

Abstract: The present invention relates to rapid dissolve thin film drug delivery compositions for the oral administration of active components. The active components are provided as taste-masked or controlled-release coated particles uniformly distributed throughout the film composition. The compositions may be formed by wet casting methods, where the film is cast and controllably dried, or alternatively by an extrusion method.

Abstract: The packet dispenser includes a container structure having an interior cavity. The cavity has a sufficient dimension such that a packet structure may be stored therein. The container structure has an opening to the cavity through which the packet structure can be removed therefrom. A tear structure is connected to the container structure such that the packet structure may contact the tear structure to tear a portion thereof when the packet structure is removed from the cavity.

Abstract: A bodily fluid analyzer, system and method for programming the same includes a sensor for sensing at least one analyte in a patient; a display; a data reader unit for reading information from a data storage unit that contains stored information concerning a particular drug being taken by or course of treatment for the patient; and a processor for setting the at least one threshold value for at least one analyte to be sensed by the sensing unit based on the information read by the data reader from the data storage unit, for processing the information concerning the analyte and for sending the processed information to the display, wherein the threshold value is associated with the particular drug taken by or course of treatment for the patient, the threshold value being one beyond which the display will display an alert.

Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component which includes polyethylene oxide, optionally blended with at least one additional polymer. The films may alternatively contain a polymer component which includes polyvinyl alcohol, optionally blended with at least one additional polymer. The films also may contain a pharmaceutical and/or cosmetic active agent.

Abstract: The present invention relates to packaging in the form of a pouch, which may contain active substances, such as food products, pharmaceutical agents, nutraceuticals and cosmetic agents, or the like. More specifically, in some embodiments, the present invention provides a pouch, which includes at least one porous substrate encompassing a closed volume and at least one water-soluble film at least partially covering the at least one porous substrate. The pouch may contain an active substance within the closed volume, as well as an active substance in the water-soluble film. The present invention also relates to methods of making and using the pouches.

Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain a topical active agent.

Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.

Abstract: The presence of a device that is implanted under the skin of a subject and that stores information that can be read by an external device is indicated by an externally visible marking on the skin of the subject.

Abstract: A method and apparatus is provided that establishes user accounts that automatically forward a user's e-mail to the user's pre-selected forwarding e-mail address(es). Each user creates a forwarding directory, which may comprise multiple e-mail accounts, that the user activates and deactivates as needed.

Abstract: Methods provide for auditing of on-line commercial transactions to determine what products are the primary motivations for a customer to begin an on-line shopping session. When a purchase is made during a shopping session, the method determines whether a purchased product is related to a previous “prime motivator” product. If so, the product is designated as a derivative product and a derivative count associated with the product is incremented. If not, the product itself is designated a prime motivator product and a prime motivator count associated with the product is incremented.

Abstract: An oral dosage delivery vehicle comprising an edible film including a uniformly distributed active ingredient, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.