Abstract: A nanoparticle for targeted siRNA delivery comprising an iron oxide core and a chitosan-polyethylene glycol-polyethylenimine copolymer coating surrounding the core, chlorotoxin covalently coupled to the coating, and an siRNA reversibly associated to the coating by non-covalent interaction. Methods for making the nanoparticle and methods for using the nanoparticle to suppress the expression of O6-methylguanine-DNA methyltransferase (MGMT), treating brain cancer, and killing cancer stem cells.

Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Abstract: A sensing and warning system includes a sensor configured to generate data regarding at least one of a user or an object, a warning device configured to be positioned on the user, and a processing circuit. The processing circuit is configured to receive the data from the sensor, determine a command based on the data, and transmit the command to the warning device prior to an impact between the user and the object. The warning device is configured to implement the command to provide a warning to the user in an attempt to (i) prevent the impact or (ii) reduce a magnitude of the impact between the user and the object.

Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Abstract: A penalty allocation system includes a processing circuit configured to receive first data from a first player-worn sensor regarding a first player involved in an impact, receive second data from a second player-worn sensor regarding a second player involved in the impact, identify one of the first player and the second player as an at-fault player in connection with the impact based on the first data and the second data, and determine a penalty for the at-fault player based on the first data and the second data.

Abstract: A penalty allocation system includes a first equipment, a second equipment, and a processing circuit. The first equipment is configured to be worn by a first player. The first equipment includes a signal-carrying material configured to carry a signal. The second equipment is configured to be worn by a second player. The second equipment includes a sensor configured to acquire signal data from the signal in response to the sensor of the second equipment directly engaging the signal-carrying material during an impact between the first equipment and the second equipment. The processing circuit is configured to determine at least one of a penalty and a reward for a recipient regarding the impact between the first player and the second player based on the signal data. The recipient includes at least one of the first player and the second player.

Abstract: An airbag inflation system includes a processing circuit configured to receive object data including positional data regarding an object and at least one of a relative velocity and a relative acceleration of the object relative to a first helmet and control operation of an inflation device to inflate an airbag based on the object data.

Abstract: A helmet with an airbag assembly coupled to the shell of the helmet. The airbag assembly includes an airbag and an inflation device. The inflation device is configured to at least partially inflate the airbag upon deployment of the airbag assembly. The helmet also includes a s processing circuit disposed at least partially within the shell. The processing circuit is configured to receive helmet data regarding a second helmet, transmit deployment data regarding inflation of the airbag assembly, and control operation of the inflation device to inflate the airbag based on the helmet data.

Abstract: An airbag inflation system includes a processing circuit configured to receive object data including positional data regarding an object and at least one of a relative velocity and a relative acceleration of the object relative to a first helmet and control operation of an inflation device to inflate an airbag based on the object data.

Abstract: Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.

Abstract: A helmet with an airbag assembly coupled to the shell of the helmet. The airbag assembly includes an airbag and an inflation device. The inflation device is configured to at least partially inflate the airbag upon deployment of the airbag assembly. The helmet also includes a processing circuit disposed at least partially within the shell. The processing circuit is configured to receive helmet data regarding a second helmet, transmit deployment data regarding inflation of the airbag assembly, and control operation of the inflation device to inflate the airbag based on the helmet data.

Abstract: An impact prediction system includes a processing circuit configured to receive remote tracking data from a remote tracking system located remote from a plurality of users, receive local tracking data from a plurality of local tracking devices, each local tracking device is worn by a different one of the plurality of users, and predict an impact between two or more of the plurality of users based on the remote tracking data and the local tracking data. The remote tracking data includes data regarding a location of each of the plurality of users. The local tracking data includes data regarding movement of each of the plurality of users.

Abstract: A penalty allocation system includes a processing circuit configured to receive first data from a first player-worn sensor regarding a first player involved in an impact, receive second data from a second player-worn sensor regarding a second player involved in the impact, identify one of the first player and the second player as an at-fault player in connection with the impact based on the first data and the second data, and determine a penalty for the at-fault player based on the first data and the second data.

Abstract: An airbag inflation system includes a processing circuit configured to receive object data including positional data regarding an object and at least one of a relative velocity and a relative acceleration of the object relative to a first helmet and control operation of an inflation device to inflate an airbag based on the object data.

Abstract: A system for predicting and warning of impacts includes a sensor located remote from a user and configured to acquire user data regarding motion of the user and object data regarding motion of the object; and a processing circuit configured to predict a potential impact between the user and the object based on the user data and the object data; and control operation of a user-wearable warning device to provide a warning output to the user in advance of a predicted time of the potential impact.

Abstract: A system for predicting and warning of impacts includes a sensor located remote from a user and configured to acquire user data regarding motion of the user and object data regarding motion of the object; and a processing circuit configured to predict a potential impact between the user and the object based on the user data and the object data; and control operation of a user-wearable warning device to provide a warning output to the user in advance of a predicted time of the potential impact.

Abstract: A system for predicting and warning of impacts includes a sensor located remote from a user and configured to acquire user data regarding motion of the user and object data regarding motion of the object; and a processing circuit configured to predict a potential impact between the user and the object based on the user data and the object data; and control operation of a user-wearable warning device to provide a warning output to the user in advance of a predicted time of the potential impact.

Abstract: A system for predicting and warning of impacts includes a sensor located remote from a user and configured to acquire user data regarding motion of the user and object data regarding motion of the object; and a processing circuit configured to predict a potential impact between the user and the object based on the user data and the object data; and control operation of a user-wearable warning device to provide a warning output to the user in advance of a predicted time of the potential impact.

Abstract: A helmet with an airbag assembly coupled to the shell of the helmet. The airbag assembly includes an airbag and an inflation device. The inflation device is configured to at least partially inflate the airbag upon deployment of the airbag assembly. The helmet also includes a processing circuit disposed at least partially within the shell. The processing circuit is configured to receive helmet data regarding a second helmet, transmit deployment data regarding inflation of the airbag assembly, and control operation of the inflation device to inflate the airbag based on the helmet data.