Patents by Inventor Richard G. H. Cotton

Richard G. H. Cotton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of mutation by resolvase cleavage
    Patent number: 5958692
    Abstract: Methods are disclosed for detecting one or more mutations in an isolated test nucleic acid by forming a heteroduplex with a homologous control DNA and contacting the heteroduplex with a resolvase capable of recognizing at least one single base pair mismatch within the heteroduplex. In preferred embodiments of the invention, the resolvase is bacteriophage T4 endonuclease VII.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: September 28, 1999
    Assignee: Variagenics, Inc.
    Inventors: Richard G. H. Cotton, Rima Youil, Borries W. Kemper
  • Detection of mismatches by resolvase cleavage using a magnetic bead support
    Patent number: 5851770
    Abstract: Disclosed is a method for detecting one or more mismatches between a first and a second nucleic acid, the first and second nucleic acids being capable of preferentially hybridizing.
    Type: Grant
    Filed: October 19, 1995
    Date of Patent: December 22, 1998
    Assignee: Variagenics, Inc.
    Inventors: Jeff Babon, Rima Youil, Jay Stoerker, Anne Huff, Richard G. H. Cotton
  • Detection of mutation by resolvase cleavage
    Patent number: 5698400
    Abstract: Methods are disclosed for detecting one or more mutations in an isolated test nucleic acid by forming a heteroduplex with a homologous control DNA and contacting the heteroduplex with a resolvase capable of recognizing at least one single base pair mismatch within the heteroduplex. In preferred embodiments of the invention, the resolvase is bacteriophage T4 endonuclease VII.
    Type: Grant
    Filed: September 16, 1996
    Date of Patent: December 16, 1997
    Assignee: Avitech Diagnostics, Inc.
    Inventors: Richard G. H. Cotton, Rima Youil, Borries W. Kemper
  • Detection of mutations in nucleic acids
    Patent number: 5217863
    Abstract: A method of detecting point mutation in nucleic acids is described which comprises hybridizing a piece of control DNA or RNA without mutations with a piece of test DNA or RNA generally corresponding to the test DNA or RNA but possibly with mutations to produce a heteroduplex, treating the heteroduplex with hydroxylamine or osmium tetroxide and with piperidine, and subjecting the resulting material to separation treatment. Individual strands of both senses of control nucleic acid can be labelled in turn allowing detection of all possible mutations.
    Type: Grant
    Filed: December 26, 1991
    Date of Patent: June 8, 1993
    Assignee: Medical Research Council
    Inventors: Richard G. H. Cotton, Robert D. Campbell