Abstract: A system and a method for the remote monitoring of an irradiated salt mass within a decay enclosure is provided. The system and the method determine a mass ratio of a first radioisotope relative to a second radioisotope, the second radioisotope having a significantly shorter half-life than the first radioisotope. In addition, the second radioisotope includes a shorter half-life than an effective half-life of the decay enclosure, and the first radioisotope includes a longer half-life than the effective half-life of the decay enclosure. The mass ratio quickly decreases outside of a target range after material diversion, while remaining below the target range for several years. As a consequence, the isotopic mass ratio presents a rapid and enduring indicator of inventory change, which is of extreme importance in detecting a diversion of the irradiated salt mass, which remains a potential proliferation target.

Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Abstract: Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

Abstract: Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.

Abstract: A system for launching, refuelling and recovering in flight an aircraft (10) such as an unmanned aerial vehicle (UAV) from a larger carrier aircraft (16) comprising a holder (22) on the carrier aircraft (16) to which the UAV (10) is detachably connectable and an extendable and retractable refuelling device (23, 24) on the carrier aircraft (16) detachably connectable to the UAV (10) whereby to launch the UAV it is disconnected from the holder (22), the refuelling device (23, 24) is extended with the UAV connected thereto to cause the UAV to trail behind the carrier aircraft and the UAV is then disconnected from the refuelling device.

Abstract: A system for launching, refuelling and recovering in flight an aircraft (10) such as an unmanned aerial vehicle (UAV) from a larger carrier aircraft (16) comprising a holder (22) on the carrier aircraft (16) to which the UAV (10) is detachably connectable and an extendable and retractable refuelling device (23, 24) on the carrier aircraft (16) detachably connectable to the UAV (10) whereby to launch the UAV it is disconnected from the holder (22), the refuelling device (23, 24) is extended with the UAV connected thereto to cause the UAV to trail behind the carrier aircraft and the UAV is then disconnected from the refuelling device.