Patents by Inventor Richard G. Vile
Richard G. Vile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240066062Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials for using T cells (e.g., chimeric antigen receptor (CAR) T cells) and one or more antigenic compositions (e.g., one or more compositions including one or more antigens) to treat a mammal (e.g., a human) having cancer are provided.Type: ApplicationFiled: December 10, 2021Publication date: February 29, 2024Inventors: Richard G. Vile, Laura Evgin, Timothy J. Kottke
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Publication number: 20240009257Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for using oncolytic viruses (e.g., replication-competent vesicular stomatitis viruses) to treat cancer are provided. Replication-competent oncolytic viruses (e.g., replication-competent oncolytic vesicular stomatitis viruses), nucleic acid molecules encoding a replication-competent oncolytic virus (e.g., replication-competent oncolytic vesicular stomatitis virus), methods for making replication-competent oncolytic viruses (e.g., replication-competent oncolytic vesicular stomatitis viruses), methods for using replication-competent oncolytic viruses (e.g., replication-competent oncolytic vesicular stomatitis viruses) to treat cancer, cancer neoantigens, nucleic acids encoding a cancer neoantigen, and methods for stimulating immune cells (e.g., cytotoxic T lymphocytes) to kill cancer cells also are provided.Type: ApplicationFiled: September 23, 2021Publication date: January 11, 2024Inventors: Richard G. Vile, Laura Evgin, Amanda L. Huff, Christopher B. Driscoll, Timothy J. Kottke, Jason M. Tonne, Jill M. Thompson, Brady N. Zell
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Publication number: 20220143116Abstract: This document relates to methods and materials for treating cancer. For example, engineered viruses (e.g., oncolytic viruses) encoding one or more inhibitors of apolipoprotein B editing complex 3B (APOBEC3B) polypeptide activity or expression and methods for using such viruses as an oncolytic agent (e.g., to treat cancer) are provided. For example, one or more engineered oncolytic viruses encoding one or more inhibitors of APOBEC3B polypeptide activity or expression can be administered to a mammal having cancer to treat that mammal.Type: ApplicationFiled: March 12, 2020Publication date: May 12, 2022Inventors: Laura Evgin, Richard G. Vile, Amanda L. Huff, Timothy J. Kottke
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Publication number: 20210369824Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: ApplicationFiled: November 4, 2020Publication date: December 2, 2021Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Publication number: 20210275615Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (OVs) in combination with an adoptive cell therapy (e.g., a chimeric antigen receptor T cell therapy) to alter one or more functions of a T cell and/or to enhance T cell expansion to treat cancer in a mammal (e.g., a human) are provided.Type: ApplicationFiled: September 13, 2019Publication date: September 9, 2021Inventors: Laura Evgin, Richard G. Vile, Luis Sanchez-Perez
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Publication number: 20210030858Abstract: This document relates to methods and materials for treating a mammal having cancer. For example, compositions (e.g., vaccines) containing cells (e.g., tumor cells) expressing APOBEC3 which can be administered to a mammal (e.g., a human) having cancer to induce an immune response (e.g., an anti-tumor immune response) within the mammal are provided.Type: ApplicationFiled: March 29, 2019Publication date: February 4, 2021Inventors: Laura Evgin, Richard G. Vile, Timothy J. Kottke, Amanda L. Huff
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Patent number: 10849964Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: GrantFiled: June 18, 2018Date of Patent: December 1, 2020Assignees: Mayo Foundation for Medical Education and Research, Leeds UniversityInventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10441643Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.Type: GrantFiled: March 19, 2015Date of Patent: October 15, 2019Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Rosa Maria Diaz, Christine Marie Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10391159Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided.Type: GrantFiled: December 5, 2018Date of Patent: August 27, 2019Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Publication number: 20190167773Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided.Type: ApplicationFiled: December 5, 2018Publication date: June 6, 2019Applicants: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10188713Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided. In general, one aspect of this document features a composition comprising, or consisting essentially of, nucleic acid encoding HIF-2a, SOX-10, C-MYC, and TYRP-1, wherein the composition comprises less than 100 separate nucleic acid molecules.Type: GrantFiled: March 19, 2015Date of Patent: January 29, 2019Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Publication number: 20190015489Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: ApplicationFiled: June 18, 2018Publication date: January 17, 2019Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10029003Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.Type: GrantFiled: November 22, 2016Date of Patent: July 24, 2018Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
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Patent number: 10022431Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: GrantFiled: February 10, 2011Date of Patent: July 17, 2018Assignees: Mayo Foundation for Medical Education and Research, Leeds UniversityInventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan Melcher, Peter Selby
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Publication number: 20170143813Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.Type: ApplicationFiled: November 22, 2016Publication date: May 25, 2017Inventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
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Publication number: 20170080065Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-lla antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.Type: ApplicationFiled: March 19, 2015Publication date: March 23, 2017Applicants: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Rosa Maria Diaz, Christine Marie Pulido, Alan A. Melcher, Peter Selby
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Publication number: 20170080066Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided. In general, one aspect of this document features a composition comprising, or consisting essentially of, nucleic acid encoding HIF-2a, SOX-10, C-MYC, and TYRP-1, wherein the composition comprises less than 100 separate nucleic acid molecules.Type: ApplicationFiled: March 19, 2015Publication date: March 23, 2017Applicants: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 9517258Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.Type: GrantFiled: March 15, 2013Date of Patent: December 13, 2016Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
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Publication number: 20150064218Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.Type: ApplicationFiled: March 15, 2013Publication date: March 5, 2015Applicants: Mayo Foundation for Medical and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
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Publication number: 20120308601Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: ApplicationFiled: February 10, 2011Publication date: December 6, 2012Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan Melcher, Peter Selby