Abstract: Compounds and compositions comprising a gap junction channel or hemichannel blocker or inhibitor, and methods of use thereof, are provided for the treatment or prevention of vascular and other diseases, disorders, and conditions

Abstract: The present invention relates to pharmaceutical agents of formula (I), useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-?B-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or disorders.

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

Abstract: The present invention relates to processes for individualizing trichome fibers from a trichome source, such as a leaf and/or a stem. One process comprises contacting the plant biomass with pectin hydrolyzing enzymes, thus releasing the individualized trichomes and recovering the individualized trichomes. A second process comprises contacting the plant biomass with an acidic aqueous solution, thus releasing the individualized trichomes and recovering the individualized trichomes. A third process comprises contacting the plant biomass with an acidic aqueous solution and with pectin hydrolyzing enzymes, thus releasing the individualized trichomes and recovering the individualized trichomes.

Abstract: A process for bleaching trichome fibers individualized from a trichome source, such as a leaf and/or a stem, is disclosed. The process of bleaching degrades trichome associated protein. Further, the bleaching processes improves the color of the trichomes, exhibiting CIELAB Color values of L* greater than 87 and b* less than 17 and with less than 0.1% protein by weight of molecular weight greater than 3,500 daltons.

Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-?B-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: A circular row of non-uniformally spaced vanes includes only one first group and only one second group of adjacent vanes, unequal first and second spacing between adjacent vanes in the first and second groups, and first spacing greater than second spacing. An embodiment with second group including only three adjacent vanes. Second spacing may be about 25%-35% smaller than a nominal uniform spacing used as a design parameter for designing spacing of the non-uniformly spaced stator vanes. Circular row may be sectored. A gas turbine engine section may include one or more rings or circular rows of fixed and/or variable non-uniformally spaced vanes. Method for designing non-uniform vane spacing for circular row includes determining nominal uniform spacing and forming first spacing and second spacing from nominal uniform spacing of vanes.

Abstract: An insulating holder for a beverage container includes a sleeve including foam and also including a front surface and a back surface. The foam is configured to reduce a rate of heat transfer between the front surface and the back surface of the sleeve. The sleeve is configured to be placed around an outer surface of the beverage container. The front surface of the sleeve is configured to be held in a hand of a user.

Abstract: A stuffing box loosening device for loosening a locking collar securing a stuffing box to a well head. The device includes a rotatable clamping tool having a clamp securable to an external surface of the locking collar. The clamp prevents relative rotational movement between itself and the locking collar. A force-receiving body extends away from the clamp. A main frame has a mounting portion securable to the well head, and the mounting portion prevents relative rotational movement between the main frame and the well head. A force-supporting body is attached to the mounting portion. An actuator is mounted to the force-supporting body and in operation extends to displace a second end to engage the force-receiving body of the clamping tool and apply a force thereto. The force rotates the clamp to loosen the locking collar.

Abstract: Method and systems are disclosed for qualifying a wireless device as frequency hopping device. In some aspects, an access point (AP) may determine a frequency hopping pattern for the wireless device, and then allocate a sequence of unique resource units to the wireless device based on the frequency hopping pattern. Each of the unique resource units include a different set of frequency subcarriers. The AP may receive a series of uplink orthogonal frequency-division multiple access (OFDMA) transmissions from the wireless device on the allocated sequence of unique resource units.

Abstract: A clamp apparatus including band means which is annular or substantially annular in form. The band means has two opposing ends and protruding means are provided to protrude outwardly of the band means at each of the opposing ends. At least one of said protruding means is integrally formed with the band means.

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

Abstract: An apparatus having an outer wall that encompasses an interior chamber that holds a predetermined volume of fluid and gas where the gas rises to one end of the interior chamber and the fluid flows to the other end of the interior chamber. The apparatus also has an inlet port that allows for fluid to ingress into the interior chamber and an outlet port that allows for fluid to egress out of the interior chamber.

Abstract: Fused aromatic bicyclic substituted 5-(2-amino-4-pyrimidinyl)-cyanoindoline derivatives (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-KB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Abstract: This disclosure provides systems, methods, and apparatus, including computer programs encoded on computer-readable media, for managing wireless local area network (WLAN) density. The WLAN density is managed to limit how many APs can utilize a first portion of a first frequency band in a geographical area. A limit of APs may be based on an estimated amount of interference that would be caused by the APs to an incumbent system that also uses the first portion of the frequency band. The WLAN density control may prevent the estimated amount of interference caused by APs in a geographical area from exceeding a threshold interference level based on the presence of the incumbent system. WLAN density control may involve the AP configuration of a first AP or may involve the density of client devices associated with one or more APs in the geographical area.

Abstract: An air removal device for an intravenous fluid system includes a housing with an inlet for fluid communication with a fluid source, a fluid outlet for fluid communication with a blood vessel of a patient, and an air outlet. The air removal device further includes a disrupting element disposed within the housing in a flow path between the inlet and the fluid outlet, and an air chamber in fluid communication with the air outlet. The disrupting element includes a protrusion extending across the flow path. The flow path includes a first cross-sectional flow area at the inlet, and a second cross-sectional flow area at the protrusion. The second cross-sectional flow area is smaller than the first cross-sectional flow area.

Abstract: An air removal device for an intravenous fluid system includes a housing with an inlet for fluid communication with a fluid source, a fluid outlet for fluid communication with a blood vessel of a patient, and an air outlet. The air removal device further includes a disrupting element disposed within the housing in a flow path between the inlet and the fluid outlet, and an air chamber in fluid communication with the air outlet. The disrupting element includes a protrusion extending across the flow path. The flow path includes a first cross-sectional flow area at the inlet, and a second cross-sectional flow area at the protrusion. The second cross-sectional flow area is smaller than the first cross-sectional flow area.