Patents by Inventor Richard H. Goodwin, Jr.
Richard H. Goodwin, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11071983Abstract: Apparatus and methods for determining whether a test compound induces cell activity, changes cell activity, prevents cell activity, or inhibits cell activity. An embodiment comprises placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from one or more sides, and detecting activity in the cells with respect to their distance from the side from which the test compound is diffusing. Embodiments may provide an apparatus that allows a side source, a point source, or both, from which a test compound solution diffuses into a cell suspension media and contacts cells. Detecting cell activity may involve detecting activity in a first cell group proximate to the side from which the test compound is diffusing, and detecting activity in a second cell group farther than the first cell group from the side from which the test compound is diffusing.Type: GrantFiled: July 24, 2019Date of Patent: July 27, 2021Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Publication number: 20190344264Abstract: Apparatus and methods for determining whether a test compound induces cell activity, changes cell activity, prevents cell activity, or inhibits cell activity. An embodiment comprises placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from one or more sides, and detecting activity in the cells with respect to their distance from the side from which the test compound is diffusing. Embodiments may provide an apparatus that allows a side source, a point source, or both, from which a test compound solution diffuses into a cell suspension media and contacts cells. Detecting cell activity may involve detecting activity in a first cell group proximate to the side from which the test compound is diffusing, and detecting activity in a second cell group farther than the first cell group from the side from which the test compound is diffusing.Type: ApplicationFiled: July 24, 2019Publication date: November 14, 2019Inventor: Richard H. Goodwin, JR.
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Patent number: 10384207Abstract: Apparatus and methods for determining whether a test compound induces cell activity, changes cell activity, prevents cell activity, or inhibits cell activity. An embodiment comprises placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from one or more sides, and detecting activity in the cells with respect to their distance from the side from which the test compound is diffusing. Embodiments may provide an apparatus that allows a side source, a point source, or both, from which a test compound solution diffuses into a cell suspension media and contacts cells. Detecting cell activity may involve detecting activity in a first cell group proximate to the side from which the test compound is diffusing, and detecting activity in a second cell group farther than the first cell group from the side from which the test compound is diffusing.Type: GrantFiled: July 19, 2016Date of Patent: August 20, 2019Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Publication number: 20170021350Abstract: Apparatus and methods for determining whether a test compound induces cell activity, changes cell activity, prevents cell activity, or inhibits cell activity. An embodiment comprises placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from one or more sides, and detecting activity in the cells with respect to their distance from the side from which the test compound is diffusing. Embodiments may provide an apparatus that allows a side source, a point source, or both, from which a test compound solution diffuses into a cell suspension media and contacts cells. Detecting cell activity may involve detecting activity in a first cell group proximate to the side from which the test compound is diffusing, and detecting activity in a second cell group farther than the first cell group from the side from which the test compound is diffusing.Type: ApplicationFiled: July 19, 2016Publication date: January 26, 2017Inventor: Richard H. Goodwin, JR.
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Patent number: 8486655Abstract: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source, and detecting activity in the cells with respect to their distance from the point source. Detecting activity in the cells can involve detecting activity in a first group of the cells proximate to the point source, and detecting activity in a second group of the cells farther from the point source than the first group.Type: GrantFiled: January 23, 2012Date of Patent: July 16, 2013Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Publication number: 20120122141Abstract: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source, and detecting activity in the cells with respect to their distance from the point source. Detecting activity in the cells can involve detecting activity in a first group of the cells proximate to the point source, and detecting activity in a second group of the cells farther from the point source than the first group.Type: ApplicationFiled: January 23, 2012Publication date: May 17, 2012Applicant: Neuro Probe IncorporatedInventor: Richard H. Goodwin, JR.
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Patent number: 8129175Abstract: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source, and detecting activity in the cells with respect to their distance from the point source. Detecting activity in the cells can involve detecting activity in a first group of the cells proximate to the point source, and detecting activity in a second group of the cells farther from the point source than the first group.Type: GrantFiled: June 11, 2009Date of Patent: March 6, 2012Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Patent number: 7704325Abstract: A crystal forming apparatus and method for using the apparatus, the method including depositing a precipitant solution in a site, incubating the site, during which time volatile vapor evaporates from the precipitant solution and accumulates in the site, and pumping the accumulated volatile vapor away from the site. An exemplary apparatus includes a sealed site except for a vent on the sealed site. In one embodiment, the vent is a passive vent that inhibits vapor diffusion out of the site. In another embodiment, the vent is an active vent that opens in response to a pressure differential. The present invention accelerates and controls the crystal growth process by pumping volatile vapor away from the sealed site.Type: GrantFiled: January 2, 2008Date of Patent: April 27, 2010Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Publication number: 20090246860Abstract: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source, and detecting activity in the cells with respect to their distance from the point source. Detecting activity in the cells can involve detecting activity in a first group of the cells proximate to the point source, and detecting activity in a second group of the cells farther from the point source than the first group.Type: ApplicationFiled: June 11, 2009Publication date: October 1, 2009Inventor: Richard H. Goodwin, JR.
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Patent number: 7547525Abstract: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source, and detecting activity in the cells with respect to their distance from the point source. Detecting activity in the cells can involve detecting activity in a first group of the cells proximate to the point source, and detecting activity in a second group of the cells farther from the point source than the first group.Type: GrantFiled: August 11, 2005Date of Patent: June 16, 2009Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Publication number: 20080134963Abstract: A crystal forming apparatus and method for using the apparatus, the method including depositing a precipitant solution in a site, incubating the site, during which time volatile vapor evaporates from the precipitant solution and accumulates in the site, and pumping the accumulated volatile vapor away from the site. An exemplary apparatus includes a sealed site except for a vent on the sealed site. In one embodiment, the vent is a passive vent that inhibits vapor diffusion out of the site. In another embodiment, the vent is an active vent that opens in response to a pressure differential. The present invention accelerates and controls the crystal growth process by pumping volatile vapor away from the sealed site.Type: ApplicationFiled: January 2, 2008Publication date: June 12, 2008Inventor: Richard H. Goodwin, Jr.
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Patent number: 7332029Abstract: A crystal forming apparatus and method for using the apparatus, the method including depositing a precipitant solution in a site, incubating the site, during which time volatile vapor evaporates from the precipitant solution and accumulates in the site, and pumping the accumulated volatile vapor away from the site. An exemplary apparatus includes a sealed site except for a vent on the sealed site. In one embodiment, the vent is a passive vent that inhibits vapor diffusion out of the site. In another embodiment, the vent is an active vent that opens in response to a pressure differential. The present invention accelerates and controls the crystal growth process by pumping volatile vapor away from the sealed site.Type: GrantFiled: August 10, 2004Date of Patent: February 19, 2008Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Patent number: 7014706Abstract: A crystal forming apparatus and method for using the apparatus, the apparatus including a plate and a film. The plate has a site adapted to hold a screening solution. The film is adjacent to the plate. The film seals the site and is adapted to contain a precipitant solution inside the site with an air gap between the screening solution and the precipitant solution. In a preferred embodiment, the film is transparent. In another preferred embodiment, the plate comprises a second transparent film supported by a lattice structure and the precipitant solution is sandwiched between the two films.Type: GrantFiled: January 28, 2004Date of Patent: March 21, 2006Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Patent number: 6767401Abstract: A crystal forming apparatus and method for using the apparatus, the apparatus including a plate and a film. The plate has a site adapted to hold a screening solution. The film is adjacent to the plate. The film seals the site and is adapted to contain a precipitant solution inside the site with an air gap between the screening solution and the precipitant solution. In a preferred embodiment, the film is transparent. In another preferred embodiment, the plate comprises a second transparent film supported by a lattice structure and the precipitant solution is sandwiched between the two films.Type: GrantFiled: January 16, 2003Date of Patent: July 27, 2004Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Patent number: 6468786Abstract: A cell activity assay apparatus (“CAAA”) and method using electromagnetic radiation detection beams to measure the cell activity, e.g, chemotactic response, includes an opaque membrane having a plurality of off-axis pores which prevent experimentally significant amounts of the electromagnetic radiation from traversing the membrane. The membrane is fabricated from opaque films that have been either ablated with substantially off axis excimer laser electromagnetic radiation to form pores, or bombarded by substantially off-axis charged particles and then etched to form pores.Type: GrantFiled: September 28, 2001Date of Patent: October 22, 2002Assignee: Neuro Probe IncorporatedInventor: Richard H. Goodwin, Jr.
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Patent number: 6395505Abstract: A cell activity assay apparatus (“CAAA”) and method using electromagnetic radiation detection beams to measure the cell activity, e.g., chemotactic response, includes an opaque membrane having a plurality of off-axis pores which prevent experimentally significant amounts of the electromagnetic radiation from traversing the membrane. The membrane is fabricated from opaque films that have been either ablated with substantially off axis excimer laser electromagnetic radiation to form pores, or bombarded by substantially off-axis charged particles and then etched to form pores.Type: GrantFiled: September 28, 2001Date of Patent: May 28, 2002Assignee: Neuro Probe, IncorporatedInventor: Richard H. Goodwin, Jr.
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Patent number: 6329164Abstract: A cell activity assay apparatus (“CAAA”) and method using electromagnetic radiation detection beams to measure the activity, e.g., chemotactic response, includes an opaque membrane having a plurality of off-axis pores which prevent experimentally significant amounts of the electromagnetic radiation from traversing the membrane. The membrane is fabricated from opaque films that have been either ablated with substantially off axis excimer laser electromagnetic radiation to form pores, or bombarded by substantially off-axis charged particles and then etched to form pores.Type: GrantFiled: March 18, 1999Date of Patent: December 11, 2001Assignee: Neuro Probe, IncorporatedInventor: Richard H. Goodwin, Jr.
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Patent number: 5302515Abstract: The present invention is a single site or multiple site chemotaxis test apparatus or chemotaxis chamber for measuring the effect of concentration gradients of diffusible chemicals upon the directional response of biological cells. The chemotactic test apparatus of the present invention comprise two compartments separated by a thin passage. The dimensions of the thin passage are selected such that cells cannot flow through the thin passage, but must deform themselves by flattening out and then "crawl" or migrate through the passage. These chambers can be used to study the migration or orientation of mobile adherent or non-adherent cells.Type: GrantFiled: August 20, 1992Date of Patent: April 12, 1994Assignee: Neuro Probe, Inc.Inventor: Richard H. Goodwin, Jr.
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Patent number: 5210021Abstract: A simple chemotactic apparatus and method wherein surface tension is used to hold cell suspensions, chemotactic factors, and control fluids in place on membrane filters. In some embodiments, chemotaxis factors and controls are placed on one side of a membrane filter, and cell suspensions are placed on the other. Gravitational flow is limited by the effect of surface tension on the fluids. In some of the preferred embodiments, grids, sheets, or occluding materials are used to further limit the gravitational fluid flow.Type: GrantFiled: March 20, 1991Date of Patent: May 11, 1993Assignee: Neuro Probe, Inc.Inventor: Richard H. Goodwin, Jr.
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Patent number: 5060658Abstract: Apparatus and methods for performing fine-needle aspiration biopsies are disclosed. Each method and apparatus includes a needle having an opening which can be occluded during both the penetration and withdrawal stages of the aspiration cycle. After penetration of the target area, the needle is reciprocated a predetermined number of times determined by the desired cytological sample yield. The needle is unoccluded during the reciprocation phase of the cycle. Both manual and automatic apparatus for performing the fine-needle aspiration biopsy procedures in accordance with the disclosed method are disclosed. Numerous sheath configurations for various biopsy applications are illustrated, including those applicable to prostate and breast or other soft tissue biopsies and for use in conjunction with ultrasonic transducers. Alternative needle configurations are disclosed to improve sample yield, reduce coring and minimize needle fouling.Type: GrantFiled: July 30, 1990Date of Patent: October 29, 1991Assignee: Vance Products IncorporatedInventors: Stephen W. Dejter, Jr., Richard H. Goodwin, Jr.