Patents by Inventor Richard H. Guenther
Richard H. Guenther has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230389543Abstract: Disclosed herein is a solid phase matrix comprising a layer of lignocellulosic fibers that can be used as effective cargo delivery for crop protection. Also disclosed is a mechanized planter for wrapping or encasing a plant seed, seed piece, seedling, or slip into the disclosed solid phase matrix. Also disclosed is a method for protecting a plant or plant that involves wrapping or encasing the plant or plant part in the disclosed solid phase matrix.Type: ApplicationFiled: October 11, 2021Publication date: December 7, 2023Inventors: Richard H. GUENTHER, Saad A. KHAN, Charles H. OPPERMAN, Lokendra PAL, Tim L. SIT, Eric Lee DAVIS, Tahira PIRZADA
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Patent number: 11427860Abstract: Methods are disclosed for identifying antibacterial compounds which inhibit propagation of selected spectrum bacteria, which bacteria use specific tRNA to code for Ala, Met, Ser, or Leu that other bacteria do not use. In one embodiment, the selected spectrum bacteria use GCA to code for Ala, whereas other bacteria use a different codon to code for alanine. The methods involve determining whether putative inhibitors promote or inhibit complex formation between the tRNA and a bacterial ribosome, or between the tRNA and an aminoacyl synthetase. Compounds which promote or inhibit complex formation can disrupt protein production, which bacteria need to propagate. The identified antibacterial compounds can selectively inhibit bacterial propagation. By limiting their effects to the selected spectrum bacteria, these compounds can treat or prevent specific bacterial infections without disrupting the normal bacterial flora, the patients' microbiome, or causing antibacterial resistance.Type: GrantFiled: August 11, 2016Date of Patent: August 30, 2022Assignee: TRANA DISCOVERY, INC.Inventors: Steven E. Peterson, Samuel P. Yenne, Joseph Christopher Ellis, Richard H. Guenther
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Patent number: 10316371Abstract: Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.Type: GrantFiled: March 29, 2012Date of Patent: June 11, 2019Assignee: TRANA DISCOVERY, INC.Inventors: Richard H. Guenther, Samuel P. Yenne, Jerzy R. Szewczyk
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Publication number: 20190022100Abstract: Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.Type: ApplicationFiled: October 9, 2018Publication date: January 24, 2019Inventors: Richard H. GUENTHER, Jerzy R. SZEWCZYK
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Publication number: 20190024152Abstract: Methods are disclosed for identifying antibacterial compounds which inhibit propagation of selected spectrum bacteria, which bacteria use specific tRNA to code for Ala, Met, Ser, or Leu that other bacteria do not use. In one embodiment, the selected spectrum bacteria use GCA to code for Ala, whereas other bacteria use a different codon to code for alanine. The methods involve determining whether putative inhibitors promote or inhibit complex formation between the tRNA and a bacterial ribosome, or between the tRNA and an aminoacyl synthetase. Compounds which promote or inhibit complex formation can disrupt protein production, which bacteria need to propagate. The identified antibacterial compounds can selectively inhibit bacterial propagation. By limiting their effects to the selected spectrum bacteria, these compounds can treat or prevent specific bacterial infections without disrupting the normal bacterial flora, the patients' microbiome, or causing antibacterial resistance.Type: ApplicationFiled: August 11, 2016Publication date: January 24, 2019Applicant: TRANA DISCOVERY, INC.Inventors: Steven E. PETERSON, Samuel P. YENNE, Joseph Christopher ELLIS, Richard H. GUENTHER
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Patent number: 10098887Abstract: Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.Type: GrantFiled: November 3, 2015Date of Patent: October 16, 2018Assignee: Trana Discovery, Inc.Inventors: Richard H. Guenther, Jerzy R. Szewczyk
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Patent number: 9877956Abstract: Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.Type: GrantFiled: January 17, 2014Date of Patent: January 30, 2018Assignee: TRANA DISCOVERY, INC.Inventors: Richard H. Guenther, Daniel Sternbach, Steven E. Peterson
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Patent number: 9677143Abstract: Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.Type: GrantFiled: February 2, 2016Date of Patent: June 13, 2017Assignee: TRANA DISCOVERY, INC.Inventor: Richard H. Guenther
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Publication number: 20160222473Abstract: Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.Type: ApplicationFiled: February 2, 2016Publication date: August 4, 2016Inventor: Richard H. Guenther
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Publication number: 20160129006Abstract: Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.Type: ApplicationFiled: November 3, 2015Publication date: May 12, 2016Inventors: Richard H. Guenther, Jerzy R. Szewczyk
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Patent number: 9249473Abstract: Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.Type: GrantFiled: June 12, 2013Date of Patent: February 2, 2016Assignee: Trana Discover, Inc.Inventor: Richard H. Guenther
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Publication number: 20150359786Abstract: Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.Type: ApplicationFiled: January 17, 2014Publication date: December 17, 2015Inventors: Richard H. Guenther, Daniel Sternbach, Steven E. Peterson
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Patent number: 9173886Abstract: The present invention is drawn to a pharmaceutical composition comprising the following compound: The compound and other azacycle derivatives can be used in method of treatments for retroviral infections, such as HIV.Type: GrantFiled: March 14, 2011Date of Patent: November 3, 2015Assignee: Trana Discovery, Inc.Inventors: Richard H. Guenther, Jerzy R. Szewczyk
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Publication number: 20140163037Abstract: Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.Type: ApplicationFiled: March 29, 2012Publication date: June 12, 2014Applicant: TRANA DISCOVERY, INC.Inventors: Richard H. Guenther, Samuel P. Yenne, Jerzy R. Szewczyk
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Publication number: 20140121124Abstract: Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.Type: ApplicationFiled: June 12, 2013Publication date: May 1, 2014Inventor: Richard H. Guenther
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Patent number: 8535727Abstract: A biodegradable delivery system for actives such as pharmaceutical drugs. The delivery system includes actives infused into the capsid of a purified plant virus. The loaded capsids are embedding in electrospun biodegradable polymer fibers, forming a nonwoven fabric.Type: GrantFiled: February 25, 2010Date of Patent: September 17, 2013Assignee: North Carolina State UniversityInventors: Behnam Pourdeyhimi, Steve A. Lommel, Sara Honarbakhsh, Ruben Carbonell, Richard H. Guenther
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Patent number: 8431341Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: GrantFiled: June 28, 2010Date of Patent: April 30, 2013Assignee: Trana Discovery, Inc.Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
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Publication number: 20130071353Abstract: Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.Type: ApplicationFiled: March 14, 2011Publication date: March 21, 2013Applicant: TRANA DISCOVERY, INCInventors: Richard H. Guenther, Jerzy R. Szewczyk
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Patent number: 8232378Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: GrantFiled: August 24, 2009Date of Patent: July 31, 2012Assignee: Trana Discovery, Inc.Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
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Publication number: 20110306509Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: ApplicationFiled: June 28, 2010Publication date: December 15, 2011Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz