Patents by Inventor Richard H. Hutchings

Richard H. Hutchings has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • pH-MODULATED QUENCHERS OF FLUORESCENCE
    Publication number: 20160116448
    Abstract: The present disclosure relates to a compound of formula (I) or a salt thereof, wherein variable A, B, and X are as defined herein. The disclosure also relates to covalent conjugates of formula (II). The disclosure further relates to the use of the compounds of formula (I) and covalent conjugates of formula (II) in methods for detecting a change in the pH of a mixture.
    Type: Application
    Filed: September 30, 2015
    Publication date: April 28, 2016
    Inventors: John C. Hodges, Richard H. Hutchings
  • NOVEL PYRAZOLE-BASED HMG CoA REDUCTASE INHIBITORS
    Publication number: 20090170852
    Abstract: Novel compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents are described. More specifically, potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (“HMG CoA reductase”) are described. Methods of using such compounds and compositions to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, Alzheimer's Disease, benign prostatic hypertrophy (BPH), diabetes and osteoporosis are also described.
    Type: Application
    Filed: October 8, 2008
    Publication date: July 2, 2009
    Inventors: Chulho Choi, Daniel Merritt Bowles, Richard H. Hutchings, William K.C. Park, Jeffrey A. Pfefferkorn
  • 5-substituted tetralones as inhibitors of ras farnesyl transferase
    Patent number: 6943183
    Abstract: The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: April 16, 2001
    Date of Patent: September 13, 2005
    Assignee: Pfizer Inc
    Inventors: William Alexander Denny, Richard H. Hutchings, Douglas S. Johnson, James Stanley Kaltenbronn, Ho Huat Lee, Daniele Marie Leonard, Jared Bruce John Milbank, Joseph Thomas Repine, Gordon William Rewcastle, Andrew David White
  • Heterocycles useful in the treatment of benign prostatic hyperplasia
    Patent number: 6841682
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the ?-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: January 11, 2005
    Assignee: Janseen Pharmaceutica N.V.
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C. F. Yim, Cynthia Maryanoff
  • 5- substituted tetralones as inhibitors of ras farnesyl trransferase
    Publication number: 20040044057
    Abstract: The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.
    Type: Application
    Filed: May 19, 2003
    Publication date: March 4, 2004
    Inventors: William Alexander Denny, Richard H Hutchings, Douglas S Johnson, James Stanely Kaltenbronn, Ho Huat Lee, Daniele Marie Leonard, Jared Bruce John Milbank, Joseph Thomas Repine, Gordon William Rewcastle, Andrew David White
  • Novel heterocycles useful in the treatment of benign prostatic hyperplasia
    Publication number: 20020165219
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I 1
    Type: Application
    Filed: November 26, 2001
    Publication date: November 7, 2002
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C.F. Yim, Cynthia Maryanoff
  • Heterocycles useful in the treatment of benign prostatic hyperplasia
    Patent number: 6384035
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: May 7, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C. F. Yim, Cynthia Maryanoff