Patents by Inventor Richard H. J. Begent

Richard H. J. Begent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified carboxypeptidase enzymes and their use
    Patent number: 6656718
    Abstract: The invention relates to improvements relating to cancer therapy based on the identification of a number of regions of CPG2 which contain epitopes which appear to be involved in the production of a host immune response and which may be modified to alter the immunogenicity in patients. Production of fusions of CPG2 with an antibody, where the CPG2 protein has been tagged provides a CPG2 protein which has reduced immunogenicity. By using partially glycosylated enzyme obtainable by P. pastoris expression, the efficacy of antibody-CPG2 fusions is enhanced.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: December 2, 2003
    Assignee: Cancer Research Technology Limited
    Inventors: Richard H. J. Begent, Kerry Chester, Nigel P. Minton, Anthony R. Rees, Surinder K. Sharma, Daniel I. R. Spencer
  • Modifided carboxypeptidase enzymes and their use
    Publication number: 20020090709
    Abstract: The invention relates to improvements relating to cancer therapy based on the identification of a number of regions of CPG2 which contain epitopes which appear to be involved in the production of a host immune response and which may be modified to alter the immunogenicity in patients. Production of fusions of CPG2 with an antibody, where the CPG2 protein has been tagged provides a CPG2 protein which has reduced immunogenicity. By using partially glycosylated enzyme obtainable by P. pastoris expression, the efficacy of antibody-CPG2 fusions is enhanced.
    Type: Application
    Filed: July 5, 2001
    Publication date: July 11, 2002
    Inventors: Richard H. J. Begent, Kerry Chester, Nigel P. Minton, Anthony R. Rees, Surinder K. Sharma, Daniel I. R. Spencer
  • Diagnosis and treatment of tumors
    Patent number: 4865835
    Abstract: There are disclosed liposomes to which are linked agents which are capable of binding an anti-tumor antibody. The liposomes are useful in the detection and treatment of tumors by reason of their ability to remove non-specifically distributed anti-tumor antibodies from vascular and other extra-cellular spaces.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: September 12, 1989
    Inventor: Richard H. J. Begent