Abstract: The invention provides various compositions, devices, and methods useful for detecting an analyte by colorimetric readout. The compositions and devices include polymers constructed to have pores specifically imprinted to provide for capture of an analyte in the pores; nanoparticles layered on the polymers; and photochromic optical switch molecules coated on the nanoparticles. Capture of the analyte in the pores of the polymer results in a change in the spatial relation of the nanoparticles layered on the polymer, which in turn causes the photochromic optical switch molecules coated thereon to undergo a change in energy state corresponding to a visible change in the optical spectra of the photochromic optical switch molecules.

Abstract: An article is provided for the detection of a drug in a liquid medium. The article includes a polymer having pores specifically imprinted to provide for capture of a drug in the pores, nanoparticles, and photochromic optical switch molecules. Capture of the drug in the pores of the polymer results in a change in the spatial relation of the nanoparticles in the polymer, causing the photochromic optical switch molecules to undergo a change in energy state which corresponds to a change in spectra of the photochromic optical switch molecules, thereby providing for detection of the drug.

Abstract: The invention provides various compositions, devices, and methods useful for detecting an analyte by colorimetric readout. The compositions and devices include polymers constructed to have pores specifically imprinted to provide for capture of an analyte in the pores; nanoparticles layered on the polymers; and photochromic optical switch molecules coated on the nanoparticles. Capture of the analyte in the pores of the polymer results in a change in the spatial relation of the nanoparticles layered on the polymer, which in turn causes the photochromic optical switch molecules coated thereon to undergo a change in energy state corresponding to a visible change in the optical spectra of the photochromic optical switch molecules.