Patents by Inventor Richard H. Kramer
Richard H. Kramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240009151Abstract: Disclosed herein are pharmaceutical compositions comprising an azobenzene photoswitch compound and an alkylated cyclodextrin. Such compositions may be administered to the eye to treat a variety of retina disorders.Type: ApplicationFiled: October 22, 2021Publication date: January 11, 2024Inventors: Richard H. KRAMER, Kevin CAO, Hovhannes GUKASYAN, Brian M. STREM
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Publication number: 20200390731Abstract: Disclosed herein, inter alia, are compositions and methods for modulating the retinoic acid receptor signaling pathway and treating vision degeneration.Type: ApplicationFiled: November 16, 2018Publication date: December 17, 2020Inventors: Richard H. Kramer, Michel Telias, Bristol Layne Denlinger, Zachary John Helft
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Patent number: 9688617Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.Type: GrantFiled: April 19, 2016Date of Patent: June 27, 2017Assignee: The Regents of the University of CaliforniaInventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
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Patent number: 9629911Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.Type: GrantFiled: January 8, 2015Date of Patent: April 25, 2017Assignee: The Regents of the University of CaliforniaInventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
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Patent number: 9428926Abstract: A prefabricated building includes a sheet folded to form a structural member defining an interior space. The structural member defines an upper guide hole that extends from the interior space of the structural member to the exterior of the structural member, and a lower guide hole that extends from the interior space of the structural member to the exterior of the structural member. The prefabricated building also includes a guide member that is fixed relative to a foundation. The structural member is aligned so that the guide member passes through the upper guide hole and the lower guide hole.Type: GrantFiled: July 19, 2011Date of Patent: August 30, 2016Inventor: Richard H. Kramer
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Publication number: 20160229794Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.Type: ApplicationFiled: April 19, 2016Publication date: August 11, 2016Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
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Patent number: 9334231Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.Type: GrantFiled: February 19, 2015Date of Patent: May 10, 2016Assignee: The Regents of the University of CaliforniaInventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
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Publication number: 20150224193Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.Type: ApplicationFiled: January 8, 2015Publication date: August 13, 2015Inventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
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Patent number: 9097707Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.Type: GrantFiled: November 8, 2012Date of Patent: August 4, 2015Assignee: The Regents of the University of CaliforniaInventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
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Publication number: 20150158811Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.Type: ApplicationFiled: February 19, 2015Publication date: June 11, 2015Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
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Patent number: 8993736Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.Type: GrantFiled: October 29, 2009Date of Patent: March 31, 2015Assignee: The Regents of the University of CaliforniaInventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
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Publication number: 20130118092Abstract: A prefabricated building includes a sheet folded to form a structural member defining an interior space. The structural member defines an upper guide hole that extends from the interior space of the structural member to the exterior of the structural member, and a lower guide hole that extends from the interior space of the structural member to the exterior of the structural member. The prefabricated building also includes a guide member that is fixed relative to a foundation. The structural member is aligned so that the guide member passes through the upper guide hole and the lower guide hole.Type: ApplicationFiled: July 19, 2011Publication date: May 16, 2013Inventor: Richard H. Kramer
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Patent number: 8309350Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.Type: GrantFiled: February 1, 2012Date of Patent: November 13, 2012Assignee: The Regents of the University of CaliforniaInventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
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Publication number: 20120190094Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.Type: ApplicationFiled: February 1, 2012Publication date: July 26, 2012Inventors: EHUD Y. ISACOFF, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
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Patent number: 8114843Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.Type: GrantFiled: November 17, 2006Date of Patent: February 14, 2012Assignee: The Regents of the University of CaliforniaInventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
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Publication number: 20110207213Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.Type: ApplicationFiled: October 29, 2009Publication date: August 25, 2011Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
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Patent number: 6837263Abstract: A liquid level control system including a tank; a source of liquid in communication with the tank; a pressure fluid actuated valve for controlling the flow of liquid to the tank from the source; a pressure sensor disposed in the tank to monitor the hydrostatic pressure determined by the quantity of liquid in the tank. A source of pressure fluid is provided which is normally vented to the atmosphere. A pressure fluid amplifier is coupled to the pressure fluid actuated valve and to the source of pressure fluid. When the pressure sensor sensed an increase of pressure caused by an increase in the liquid level in the tank, the pressure fluid amplifier is effective to actuate the valve to close and militate against flowing into the tank to maintain the liquid at a predetermined level.Type: GrantFiled: October 20, 2001Date of Patent: January 4, 2005Assignee: DistaView CorporationInventor: Richard H. Kramer
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Publication number: 20020078995Abstract: A liquid level control system including a tank; a source of liquid in communication with the tank; a pressure fluid actuated valve for controlling the flow of liquid to the tank from the source; a pressure sensor disposed in the tank to monitor the hydrostatic pressure determined by the quantity of liquid in the tank. A source of pressure fluid is provided which is normally vented to the atmosphere. A pressure fluid amplifier is coupled to the pressure fluid actuated valve and to the source of pressure fluid. When the pressure sensor sensed an increase of pressure caused by an increase in the liquid level in the tank, the pressure fluid amplifier is effective to actuate the valve to close and militate against flowing into the tank to maintain the liquid at a predetermined level.Type: ApplicationFiled: October 20, 2001Publication date: June 27, 2002Inventor: Richard H. Kramer
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Patent number: 5545958Abstract: A merchandising system for holding items, such as compact discs, is disclosed. The system includes a base on which several item holders are rotatably mounted. Each item holder is configured to receive at least one and preferably a plurality of items arranged vertically. A plurality of motors rotate the items while cooperating sensors provide an output corresponding to the rotational position of the item holder. A controller is coupled between the sensors and motors to maintain alignment of rotation based on the output signals received from the sensors.Type: GrantFiled: October 13, 1994Date of Patent: August 13, 1996Assignee: KCS Industries, Inc.Inventor: Richard H. Kramer