Patents by Inventor Richard H. Rupp

Richard H. Rupp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5284856
    Abstract: Compounds of the formula I ##STR1## in which the substituents R.sub.1 -R.sub.5 and n and m are as defined are suitable for controlling tumors.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: February 8, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ramchandra G. Naik, Bansi Lal, Richard H. Rupp, Hans H. Sedlacek, Gerhard Dickneite
  • Patent number: 5271935
    Abstract: Cammunocin, an active substance which can be obtained by cultivation of Streptomyces species Y-84,36210 (DSM 4329), has antibiotic and immunosuppressant activity.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: December 21, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Christopher M. M. Franco, Sugata Chatterjee, Erra K. S. Vijayakumar, Bimal N. Ganguli, Richard H. Rupp
  • Patent number: 5252598
    Abstract: The present invention relates to labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a positive ionotropic effect, an effect of lowering intraocular pressure and lowing blood pressure.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: October 12, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Yatendra Khandelwal, Greta Moraes, Bansi Lal, Vijay A. Aroskar, Alihussein N. Dohadwalla, Richard H. Rupp
  • Patent number: 5225427
    Abstract: 10-substituted ether derivatives of 3.alpha., 12.alpha.-Epoxy-3,4,5 5a.alpha., 6,7,8,8a.alpha.,9,10,12.beta., 12a-dodecahydro-10-hydroxy-3.beta.,6.alpha.,9.beta.-trimethylpyano-(4,3-j) (1,2) benzodioxepin, also known as Dihydroartemisinin or Dihydroquinghaosu (DHQ), pharmaceutically acceptable salts thereof, processes for their preparation and their use as chemotherapeutics against protozoal infections are provided.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: July 6, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Bindumadhavan Venugopalan, Chintamani P. Bapat, Pravin J. Karnik, Bansi Lal, Dipak K. Chatterjee, Subramani N. Iver, Richard H. Rupp
  • Patent number: 5219865
    Abstract: The present invention relates to combinations of the malaria therapeutics artemisinine, dihydroartemisinine, arteether, artemether, artesunate or other artemisinine derivatives with one or more of the antimalarials chloroquine, 10-0-methylfloxacrine, quinine, mefloquine, amodiaquine, pyrimethamine, sulfadoxine and primaquine. Synergistic actions are achieved with them on treatment of mammals, including humans, with subcurative doses of the individual substances.
    Type: Grant
    Filed: April 9, 1992
    Date of Patent: June 15, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dipak C. Chatterjee, Bindumadhavan Venugopalan, Bansi Lal, Noel J. de Souza, Richard H. Rupp
  • Patent number: 5206241
    Abstract: Labdanes of the formula ##STR1## a process for their manufacture, pharmaceutical preparations containing an effective amount of these compounds and their use for the manufacture of a pharmaceutical preparation for treatment of cardiovascular diseases and high intraocular pressure.
    Type: Grant
    Filed: March 14, 1991
    Date of Patent: April 27, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Yatendra Khandelwal, Rajeshwari Kannan, Bansi Lal, Ramanujam Rajagopalan, Vijay A. Aroskar, deceased AliHussein N. Dohadwalla, Rashida A. Dohadwalla, Anis S. Dohadwalla, Samina A. Dohadwalla, Richard H. Rupp
  • Patent number: 5141936
    Abstract: Pyrimido-(6,1-a)-isoquinolin-4-one derivatives of the formula ##STR1## in which the substituents R.sup.1 -R.sup.6 have the meanings mentioned, are suitable for the prevention of hair loss and for strengthening hair growth.
    Type: Grant
    Filed: May 17, 1989
    Date of Patent: August 25, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Richard H. Rupp, Bansi Lal
  • Patent number: 5112806
    Abstract: Mersacidin, a cyclic peptide of the formula I ##STR1## has antibiotic activity.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: May 12, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Sukumar Chatterjee, Sugata Chatterjee, Bimal N. Ganguli, Deepak K. Chatterjee, Rajendra K. H. Jani, Richard H. Rupp, Hans-Wolfram Fehlhaber, Herbert Kogler, Gerhard Seibert, Volker Teetz
  • Patent number: 5112858
    Abstract: A new antibiotic, aranorosin, a microbiological process for the preparation thereof, and the use thereof as a pharmaceutical.Aranorosin, a compound of the formula ##STR1## can be prepared with the aid of the fungus culture Y-30499 (DSM 4151). Aranorosin has an antibiotic action as well as an action against malignant tumors.
    Type: Grant
    Filed: May 11, 1989
    Date of Patent: May 12, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Kirity Roy, Triptikumar Mukhopadhyay, Goukanapalli C. S. Reddy, Erra K. S. Vijayakumar, Bimal N. Ganguli, Richard H. Rupp, Hans-Wolfram Fehlhaber, Herbert Kogler
  • Patent number: 5093331
    Abstract: The present invention relates to polyoxygenated labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a positive inotropic effect, an effect of lowering intraocular pressure and lowering blood pressure.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: March 3, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Bansi Lal, Ashok K. Gangopadbya, Alihussein N. Dohadwalla, Ramanujam Rajgopalan, Richard H. Rupp
  • Patent number: 5001258
    Abstract: Fumifungin, a compound of the formula ##STR1## can be isolated from the culture broth of fungus culture No. Y-83,0405 (DSM 4152), and has bactericidal and fungicidal properties.
    Type: Grant
    Filed: June 23, 1988
    Date of Patent: March 19, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Triptikumar Mukhopadhyay, Kirity Roy, Hans-Wolfram Fehlhaber, Richard H. Rupp, Bimal N. Ganguli
  • Patent number: 4988677
    Abstract: The present invention relates to the macrolide antibiotic swalpamycin, to a microbiological process for its preparation, to a new microorganism strain Streptomyces species, and to the use of swalpamycin as a medicinal agent for the treatment of infections caused by bacteria, mycoplasmas and Actinomycetes.
    Type: Grant
    Filed: August 25, 1987
    Date of Patent: January 29, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Christopher M. M. Franco, Julia Gandhi, Sugata Chatterjee, Goukanapalli C. S. Reddy, Bimal N. Ganguli, Richard H. Rupp, Herbert Kogler, Hans-Wolfram Fehlhaber
  • Patent number: 4900727
    Abstract: The present invention relates to novel 4H-1-benzopyran-4-one derivatives, to processes for the preparation thereof and to their use as anti-inflammatory, analgesic, immuno-suppressive and anti-allergic agents. In particular, the present invention relates to novel compounds of the formula I, ##STR1## in which R.sub.1 is hydrogen, alkyl having 1 to 6 carbon atoms, arly-C.sub.1 -C.sub.4 -alkyl, substituted C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkyl-C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, aryl or carboxyl or an aldehyde or COO--C.sub.1 -C.sub.4 -alkyl group, R.sub.2 is hydrogen, alkyl having 1 to 6 carbon atoms, nitro, amino, di-C.sub.1 -C.sub.4 -alkylamino or a halogen, R.sub.3 is C.sub.1 -C.sub.4 -alkyl, substituted C.sub.1 -C.sub.4 -alkyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, aryl-C.sub.1 -C.sub.4 -alkyl, nitro, amino, a C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino group or halogen, R.sub.
    Type: Grant
    Filed: January 26, 1989
    Date of Patent: February 13, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Samba L. Kattige, Ramchandra G. Naik, Aftab D. Lakdawalla, Alihussein N. Dohadwalla, Richard H. Rupp, Noel J. de Souza
  • Patent number: 4803204
    Abstract: The present invention relates to novel, 1-substituted 3-aryl-7-chloro-3,4-dihydro-(2H)-acridone N-oxides, a process for their preparation, pharmaceutical compositions containing these compounds, and their use as chemotherapeutic agents, in particular as antimalarials and coccidiostatics.
    Type: Grant
    Filed: July 20, 1987
    Date of Patent: February 7, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rajkumar Dhar, Bindumadhavan Venugopalan, Dipak K. Chatterjee, Richard H. Rupp, Noel J. de Souza
  • Patent number: 4724238
    Abstract: The present invention relates to a process for the isolation of labdan derivatives from the plant Coleus forskohlii, and their use as medicaments having anti-inflammatory and analgesic activity.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: February 9, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alihussein N. Dohadwalla, Sadashiv S. Mandrekar, Nandkumar K. Dadkar, Yatendra Khandelwal, Richard H. Rupp, Noel J. de Souza
  • Patent number: 4548936
    Abstract: The present invention relates to .DELTA..sup.1 -pyrroline thiolactim ethers of the general formula I ##STR1## which have a more specific action and/or a longer-lasting action than PGI.sub.2, and to a process for their preparation.The compounds are distinguished by a platelet aggregation-inhibiting action and a blood vessel-relaxing and hypotensive action, and can therefore be used as medicaments.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: October 22, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Wilhelm Bartmann, Jochen Knolle, Richard H. Rupp
  • Patent number: 4371542
    Abstract: What are disclosed are prostacylin PGI.sub.2 analogs of the formula ##STR1## having a more specific or longer lasting pharmacological action than PGI.sub.2, methods of making these analogs; and methods and pharmaceutical preparations for inhibiting blood platelet aggregation, for treating hypertension, for the treatment or prophylaxis of gastrointestinal ulcers, and for the treatment of asthma.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: February 1, 1983
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Jochen Knolle, Richard H. Rupp, Bernward Scholkens
  • Patent number: 4304783
    Abstract: The invention relates to new prostaglandin derivatives of the 6-keto-PGE.sub.1 series, to processes and intermediates for their manufacture and to their use as medicaments.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: December 8, 1981
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Ulrich Lerch, Bernward Scholkens, Richard H. Rupp