Patents by Inventor Richard H. Weindruch

Richard H. Weindruch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of genetic markers of biological age and metabolism
    Publication number: 20080254464
    Abstract: A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid that have been predetermined by either increase or decrease in response to biological aging of the organ, tissue or cell. A method of obtaining biomarkers of aging is also disclosed.
    Type: Application
    Filed: November 20, 2006
    Publication date: October 16, 2008
    Inventors: Richard H. Weindruch, Tomas A. Prolla, Cheol-Koo Lee
  • Methods of screening for compounds that inhibit expression of biomarker sequences differentially expressed with age in mice
    Patent number: 7041449
    Abstract: A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment, the method comprises the steps of: (a) obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell, wherein the nucleic acid is RNA or a cDNA copy of RNA and (b) determining the gene expression pattern of at least one of the genes selected from the group consisting of M21050, Z49204, U49430, K02782, X58861, X66295, M22531, X67809, U19118, M64086, M63695, U39066, X92590, X56518, AA182189, X16493, U20344, X16834, X82648, D00754, D16313, L38971 and X15789.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: May 9, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tomas A. Prolla, Richard H. Weindruch, Cheol-Koo Lee, Tsuyoshi Kayo
  • Identification of genetic markers of biological age and metabolism
    Publication number: 20030157526
    Abstract: A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid that have been predetermined by either increase or decrease in response to biological aging of the organ, tissue or cell. A method of obtaining biomarkers of aging is also disclosed.
    Type: Application
    Filed: December 2, 2002
    Publication date: August 21, 2003
    Inventors: Richard H. Weindruch, Tomas A. Prolla, Cheol-Koo Lee
  • Identification of genetic markers of biological age and metabolism
    Patent number: 6569624
    Abstract: A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid that have been predetermined by either increase or decrease in response to biological aging of the organ, tissue or cell. A method of obtaining biomarkers of aging is also disclosed.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: May 27, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Richard H. Weindruch, Tomas A. Prolla, Cheol-Koo Lee
  • Gene expression alterations underlying the retardation of aging by caloric restriction in mammals
    Publication number: 20030036079
    Abstract: A method of measuring the relative metabolic state of a multicellular organism is disclosed.
    Type: Application
    Filed: June 24, 2002
    Publication date: February 20, 2003
    Inventors: Richard H. Weindruch, Tomas A. Prolla, Cheol-Koo Lee, Tsuyoshi Kayo
  • Identification of gene expression alterations underlying the aging process in mammals
    Publication number: 20030032030
    Abstract: A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment, the method comprises the steps of: (a) obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell, wherein the nucleic acid is RNA or a cDNA copy of RNA and (b) determining the gene expression pattern of at least one of the genes selected from the group consisting of M21050, Z49204, U49430, K02782, X58861, X66295, M22531, X67809, U19118, M64086, M63695, U39066, X92590, X56518, AA182189, X16493, U20344, X16834, X82648, D00754, D16313, L38971 and X15789.
    Type: Application
    Filed: March 15, 2002
    Publication date: February 13, 2003
    Inventors: Tomas A. Prolla, Richard H. Weindruch, Cheol-Koo Lee, Tsuyoshi Kayo