Abstract: The invention relates to novel compounds of formula (I), the compounds being capable of acting as av?6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, —C(O)R1a, —C(O)OR1a —C(O)NHR1a, —C(O)N(R1a)2, —SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.

Abstract: Internal components of power generation machinery, including for example gas or steam industrial turbines as well as generators, are inspected a camera inspection system that is inserted and positioned within the machinery by an elongated cable carrier that has restricted cable flexure along a two-dimensional carrier cable flexure motion plane. A camera head that retains the camera is coupled to a distal end of the cable carrier. Embodiments also include a connector block coupled between the cable carrier distal end and the camera head. The connector block has a pivot axis coupled to the camera head for swinging the camera head along a camera head range of motion path that intersects the cable carrier flexure motion plane. Embodiments include a camera head swing motion drive system for selectively positioning the camera head along the camera head range of motion path.

Abstract: An on-line optical inspection and monitoring system is externally mounted to existing man way service access within the combustor housing. A replacement man way cover having an optical window is mounted to the combustor housing. One or more optical cameras are oriented so that the camera field of view (FOV) is directed through the man way cover optical window. The camera FOV is moved to plural positions within the combustion section, such as under control of an automated motion control system, and images are captured. Multiple images are combined to form a composite image, which may include an image of an entire transition within the combustion section. Visual images and/or infrared (IR) thermal images may be captured. Thermal image information is correlated with component temperature. Image information is utilized to determine vibration characteristics of the imaged components.

Abstract: Internal components of gas and steam turbines are inspected with an optical camera inspection system that is capable of automatically and/or manually positioning the camera field of view (FOV) to an area of interest within the turbine along a pre-designated navigation path and capturing images with or without human intervention. Camera positioning and image capture can be initiated automatically or after receipt of operator permission. The inspection system includes an articulated multi-axis inspection scope with an optical camera that is inserted through a combustor nozzle access port, combustor and transition, so that the camera FOV captures the leading edge of Row 1 rotating turbine blades while the rotor is spinning at up to 1000 RPM. An illumination system strobe light and the camera image capture are synchronized with the blade rotation speed so that images of multiple or all blades may be obtained from a single inspection scope insertion point.

Abstract: Internal components of gas or steam turbines are inspected with a 3D scanning camera inspection system that is inserted and positioned within the turbine, for example through a gas turbine combustor nozzle port. Three dimensional internal component measurements are performed using projected light patterns generated by a stripe projector and a 3D white light matrix camera. Real time dimensional information is gathered without physical contact, which is helpful for extracting off-line engineering information about the scanned structures. Exemplary 3D scans, preferably with additional visual images, are performed of the gas path side of a gas turbine combustor support housing, combustor basket and transition with or without human intervention.

Abstract: Internal components of power generation machinery, such as gas and steam turbines are inspected with an optical camera inspection system that is capable of automatically positioning the camera field of view (FOV) to an area of interest within the machinery along a pre-designated navigation path and capturing images without human intervention. Automatic camera positioning and image capture can be initiated automatically or after receipt of operator permission. The pre-designated navigation path can be defined by operator manual positioning of an inspection scope within the power machine or a similar one of the same type and recording of positioning steps for future replication. The navigation path can also be defined by virtual simulation.

Abstract: Internal components of power generation machinery, such as gas and steam turbines are inspected with an optical camera inspection system that is capable of automatically positioning the camera field of view (FOV) to an area of interest within the machinery along a pre-designated navigation path and capturing images without human intervention. Automatic camera positioning and image capture can be initiated automatically or after receipt of operator permission. The pre-designated navigation path can be defined by operator manual positioning of an inspection scope within the power machine or a similar one of the same type and recording of positioning steps for future replication. The navigation path can also be defined by virtual simulation. The inspection system includes an articulated multi-axis inspection scope.

Abstract: A measurement device for a generator and a method for measuring stator wedge preload are disclosed. The generator includes a stator and a rotor, the stator including a stator wedge. The measurement device includes a force application device, the force application device including an actuator operable to apply a force to the stator wedge. The measurement device further includes a sensor operable to measure displacement of the stator wedge. The measurement device further includes a controller in communication with the force application device and the sensor and configured to collect data associated with the force and the displacement.

Abstract: Internal components of power generation machinery, including for example gas or steam industrial turbines as well as generators, are inspected a camera inspection system that is inserted and positioned within the machinery by an elongated cable carrier that has restricted cable flexure along a two-dimensional carrier cable flexure motion plane. A camera head that retains the camera is coupled to a distal end of the cable carrier. Embodiments also include a connector block coupled between the cable carrier distal end and the camera head. The connector block has a pivot axis coupled to the camera head for swinging the camera head along a camera head range of motion path that intersects the cable carrier flexure motion plane. Embodiments include a camera head swing motion drive system for selectively positioning the camera head along the camera head range of motion path.

Abstract: An on-line optical inspection and monitoring system is externally mounted to existing man way service access within the combustor housing. A replacement man way cover having an optical window is mounted to the combustor housing. One or more optical cameras are oriented so that the camera field of view (FOV) is directed through the man way cover optical window. The camera FOV is moved to plural positions within the combustion section, such as under control of an automated motion control system, and images are captured. Multiple images are combined to form a composite image, which may include an image of an entire transition within the combustion section. Visual images and/or infrared (IR) thermal images may be captured. Thermal image information is correlated with component temperature. Image information is utilized to determine vibration characteristics of the imaged components.

Abstract: A measurement device for a generator and a method for measuring stator wedge preload are disclosed. The generator includes a stator and a rotor, the stator including a stator wedge. The measurement device includes a force application device, the force application device including an actuator operable to apply a force to the stator wedge. The measurement device further includes a sensor operable to measure displacement of the stator wedge. The measurement device further includes a controller in communication with the force application device and the sensor and configured to collect data associated with the force and the displacement.

Abstract: Internal components of gas and steam turbines are inspected with an optical camera inspection system that is capable of automatically and/or manually positioning the camera field of view (FOV) to an area of interest within the turbine along a pre-designated navigation path and capturing images with or without human intervention. Camera positioning and image capture can be initiated automatically or after receipt of operator permission. The inspection system includes an articulated multi-axis inspection scope with an optical camera that is inserted through a combustor nozzle access port, combustor and transition, so that the camera FOV captures the leading edge of Row 1 rotating turbine blades while the rotor is spinning at up to 1000 RPM. An illumination system strobe light and the camera image capture are synchronized with the blade rotation speed so that images of multiple or all blades may be obtained from a single inspection scope insertion point.

Abstract: Internal components of gas or steam turbines are inspected with a 3D scanning camera inspection system that is inserted and positioned within the turbine, for example through a gas turbine combustor nozzle port. Three dimensional internal component measurements are performed using projected light patterns generated by a stripe projector and a 3D white light matrix camera. Real time dimensional information is gathered without physical contact, which is helpful for extracting off-line engineering information about the scanned structures. Exemplary 3D scans, preferably with additional visual images, are performed of the gas path side of a gas turbine combustor support housing, combustor basket and transition with or without human intervention.

Abstract: Internal components of power generation machinery, such as gas and steam turbines are inspected with an optical camera inspection system that is capable of automatically positioning the camera field of view (FOV) to an area of interest within the machinery along a pre-designated navigation path and capturing images without human intervention. Automatic camera positioning and image capture can be initiated automatically or after receipt of operator permission. The pre-designated navigation path can be defined by operator manual positioning of an inspection scope within the power machine or a similar one of the same type and recording of positioning steps for future replication. The navigation path can also be defined by virtual simulation.

Abstract: Internal components of power generation machinery, such as gas and steam turbines are inspected with an optical camera inspection system that is capable of automatically positioning the camera field of view (FOV) to an area of interest within the machinery along a pre-designated navigation path and capturing images without human intervention. Automatic camera positioning and image capture can be initiated automatically or after receipt of operator permission. The pre-designated navigation path can be defined by operator manual positioning of an inspection scope within the power machine or a similar one of the same type and recording of positioning steps for future replication. The navigation path can also be defined by virtual simulation. The inspection system includes an articulated multi-axis inspection scope.

Abstract: A method is provided for in situ inspection of a wear pad gap in a gas turbine engine combustor. The wear pad gap is defined between a wear pad of a transition piece impingement sleeve and a forward ring of a flow duct of the combustor. The method includes coupling a guide to the combustor such that the guide at least partially extends within a space between the impingement sleeve and a body of the transition piece, displacing an inspection head along the guide within the space between the impingement sleeve and the transition piece body such that the inspection head is positioned adjacent a wear pad, and inspecting the wear pad gap.

Abstract: An inspection head for an air gap inspection device. The inspection head may include a pair of expandable shoes, an inspection device attached to the pair of shoes, and a transducer assembly attached to one of the pair of shoes.

Abstract: A borescope is received within a housing. The borescope includes a flexible end portion carrying the video head and a housing includes a flexible end portion comprised of ball-socket segments and a tip for following the movement of the flexible end portion of the borescope. Cooling air is provided in an annular passage between the borescope and housing for flow about the borescope to maintain the video head temperature below its temperature limitation. Two cables maintain the ball-socket segments and tip in contact with a transition piece and with one another to enable the flexible borescope end portion to follow the movement of the directionally controlled video head.

Abstract: An inspection assembly adapted to traverse an inspection surface, the assembly includes: a crawler body including a first side and a bottom side, wherein the first side is adapted to face a first inspection surface and the bottom side is adapted to engage a second inspection surface separated from the first inspection surface by a gap; a suction module in the crawler body adapted to create a suction between the first inspection surface to bias the crawler body against the first inspection surface; at least one roller mounted in the crawler body adapted to engage the first inspection surface, and at least one mast having a mount to receive a sensor, wherein said mast extendable from the crawler body into the gap.

Abstract: A probe is pulled along a cooling slot of a turbine wheel to detect defects along the slot surfaces. The cooling slot extends radially inwardly of the bases of both the dovetails and dovetail slots. A housing assembly is releasably coupled to the rim of the turbine wheel and a motor draws the probe along the cooling slot at constant speed. A guide and brushes on the probe serve to bias the probe radially outwardly against the surfaces to be inspected as the probe is drawn along the cooling slot.