Patents by Inventor Richard Heier

Richard Heier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRROLOPYRIMIDINE ITK INHIBITORS
    Publication number: 20240132505
    Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.
    Type: Application
    Filed: October 24, 2023
    Publication date: April 25, 2024
    Inventors: Eric Jon JACOBSEN, David Randolph ANDERSON, James Robert BLINN, Susan Landis HOCKERMAN, Richard HEIER, Paramita MUKHERJEE
  • Pyrrolopyrimidine ITK inhibitors
    Patent number: 11820775
    Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: November 21, 2023
    Assignee: Aclaris Therapeutics, Inc.
    Inventors: Eric Jon Jacobsen, David Randolph Anderson, James Robert Blinn, Susan Landis Hockerman, Richard Heier, Paramita Mukherjee
  • PYRROLOPYRIMIDINE ITK INHIBITORS
    Publication number: 20220348579
    Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.
    Type: Application
    Filed: April 21, 2021
    Publication date: November 3, 2022
    Inventors: Eric Jon JACOBSEN, David Randolph ANDERSON, James Robert BLINN, Susan Landis HOCKERMAN, Richard HEIER, Paramita MUKHERJEE
  • Pyrrolopyrimidine ITK inhibitors
    Patent number: 11021482
    Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: June 1, 2021
    Assignee: Adaris Therapeutics, Inc.
    Inventors: Eric Jon Jacobsen, David Randolph Anderson, James Robert Blinn, Susan Landis Hockerman, Richard Heier, Paramita Mukherjee
  • PYRROLOPYRIMIDINE ITK INHIBITORS
    Publication number: 20200048262
    Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.
    Type: Application
    Filed: August 12, 2019
    Publication date: February 13, 2020
    Inventors: Eric Jon JACOBSEN, David Randolph ANDERSON, James Robert BLINN, Susan Landis HOCKERMAN, Richard HEIER, Paramita MUKHERJEE
  • (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione and method of preparation thereof
    Publication number: 20060040929
    Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from about 0.2 thru 8 mg/person/dose and where the sexually mating amount is from about 0.003 thru 0.2 mg/kg/dose. The present invention also provides a novel pharmaceutical agent, (5R)-5 -(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: July 27, 2005
    Publication date: February 23, 2006
    Inventors: Robert McCall, Martin Meglasson, Brad Acker, Richard Heier, Alan Jin, Malcolm Moon
  • Substituted pyrazole urea compounds for the treatment of inflammation
    Publication number: 20050197338
    Abstract: Compounds of Formula I: wherein X1, X2, L1, A, R, L2, R1, R12, R12a, R13, R14 and R14a are as defined herein, are disclosed.
    Type: Application
    Filed: October 21, 2004
    Publication date: September 8, 2005
    Inventors: He Huang, Michael Stealey, Gunnar Hanson, Patrick Lennon, Bruce Hamper, Jin Xie, David Oburn, Serge Wolfson, Theresa Fletcher, Richard Heier, Matthew Reding, Michael Clare
  • Inhibitors of HCV NS5B polymerase
    Publication number: 20050154056
    Abstract: The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.
    Type: Application
    Filed: November 3, 2004
    Publication date: July 14, 2005
    Inventors: Fan Yang, Bo Zhang, Nancy Wicnienski, Jeffrey Pfefferkorn, Meredith Greene, Ke Chen, Richard Nugent, Matthew Reding, Robert Kelly, Mark Mitchell, Lee Funk, Richard Heier, Rebecca Anderson