Patents by Inventor Richard Heys

Richard Heys has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ligands
    Patent number: 7982038
    Abstract: A radioactive compound having the formula: and pharmaceutically-acceptable salts thereof, wherein R1 and Ar are as defined in the specification, enantiomers, in vivo-hydrolysable precursors, pharmaceutical compositions and formulations containing them, methods of using them to treat diseases and conditions either alone or in combination with other therapeutically-active compounds or substances, processes and intermediates used to prepare them and uses of them for diagnostic and analytic purposes.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: July 19, 2011
    Assignee: AstraZeneca AB
    Inventors: Peter Dorff, John Gordon, John Richard Heys, Richard A Keith, Dennis J McCarthy, Mark A Smith, Eifion Phillips
  • Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor
    Publication number: 20100034741
    Abstract: The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the ?7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express ?7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.
    Type: Application
    Filed: January 26, 2009
    Publication date: February 11, 2010
    Applicants: The Johns Hopkins University
    Inventors: Martin G. Pomper, John L. Musachio, Hong Fan, Robert F. Dannals, Catherine Foss, Eifion Phillips, John Gordon, Dennis McCarthy, Richard Keith, Mark Smith, Richard Heys, Peter N. Dorff
  • Radioligands for the 5 -Ht1b Receptor
    Publication number: 20090004106
    Abstract: The present invention provides novel radioligands for the 5-HT1B receptor of the formula I.
    Type: Application
    Filed: February 14, 2007
    Publication date: January 1, 2009
    Inventors: John Richard Heys, Edward Pierson, William Potts
  • Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor
    Publication number: 20050129610
    Abstract: The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the a7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express a7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.
    Type: Application
    Filed: June 24, 2004
    Publication date: June 16, 2005
    Inventors: Martin Pomper, John Musachio, Hong Fan, Robert Dannals, Catherine Foss, Eifion Phillips, John Gordon, Dennis McCarthy, Richard Keith, Mark Smith, Richard Heys, Peter Dorff
  • Antibodies produced against cytokine suppressive anti-inflammatory drug binding proteins
    Patent number: 6361773
    Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: John C. Lee, Jerry L. Adams, Timothy F. Gallagher, David W. Green, John Richard Heys, Peter C. McDonnell, Dean E. McNulty, Peter R. Young, James E. Strickler
  • Polynucleotides encoding cytokine suppressive anti-inflammatory drug binding proteins
    Patent number: 5955366
    Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: September 21, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: John C. Lee, Jerry L. Adams, Timothy F. Gallagher, David W. Green, John Richard Heys, Peter C. McDonnell, Dean E. McNulty, James E. Strickler, Peter R. Young
  • Screening methods using cytokine suppressive anti-inflammatory drug (CSAID) binding proteins
    Patent number: 5871934
    Abstract: This invention relates to methods of screening for pharmaceuticals using Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding proteins.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: February 16, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: John Cheung-Lun Lee, Jerry Leroy Adams, Timothy Francis Gallagher, David W. Green, John Richard Heys, Peter Colon McDonnell, Dean Edward McNulty, James E. Strickler, Peter Ronald Young
  • Cytokine suppressive anit-inflammatory drug binding proteins
    Patent number: 5783664
    Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: July 21, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: John C. Lee, Jerry L. Adams, Timothy F. Gallagher, David W. Green, John Richard Heys, Peter C. McDonnell, Dean E. McNulty, James E. Strickler, Peter R. Young
  • Oligonucleotides comprising a region of a cytokine suppressive anti-inflammatory drug binding protein
    Patent number: 5777097
    Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 7, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: John C. Lee, Jerry L. Adams, Timothy F. Gallagher, David W. Green, John Richard Heys, Peter C. McDonnell, Dean E. McNulty, Peter R. Young, James E. Strickler