Abstract: Packaging for moist smokeless tobacco can be provided in the form of a refill unit comprising a base portion (10) configured to fit in the bottom of an existing moist smokeless tobacco product container and a lid portion (30).

Abstract: A method for co-extracting non-combustible ore (e.g., trona) and methane from an underground formation comprising at least one methane-bearing layer and a non-combustible ore bed having a rock roof, comprising: providing a well having a downhole end positioned above the ore bed roof; mining an ore region from an initial cavity and removing the mined ore, thereby creating a subsequent cavity; advancing the mining step to another ore region from the subsequent cavity; allowing the roof of the initial cavity to cave so as to create a gob; repeating the mining, advancing and caving steps, the caving being effective in generating fluid communication between the gob and the well downhole end and in fracturing the methane-bearing layer so as to release methane into the gob; and recovering a gob gas comprising released methane through the well to the surface.

Abstract: The present invention relates to the isolation of carotenoids and in particular the xanthophyll zeaxanthin (zeaxanthin-?,?-Carotene-3,3?-diol) and optionally other carotenoids such as lycopene, ?,?-carotene, 3?-hydroxyechinenone ?-cryptoxanthin and the colourless carotenoids, phytoene and phytofluene from a marine bacterium belonging to the genus Algibacter which is capable of producing the aforementioned compounds. The present invention also provides a strain of Algibacter which is capable of producing significant levels of carotenoids, especially zeaxanthin at high purity, as well as methods of using the Algibacter strain and uses of the carotenoids produced.

Abstract: One or more computer-readable media including computer-executable instructions to instruct a computing system to access a template, instantiate the template for a realization of a data-driven application, perform an analysis defined by the template where the analysis relies on linking to at least some data relied on by the data-driven application and output information based at least in part on the analysis. Various other apparatuses, systems, methods, etc., are also disclosed.

Abstract: Packaging for moist smokeless tobacco can be provided in the form of a refill unit comprising a base portion (10) configured to fit in the bottom of an existing moist smokeless tobacco product container and a lid portion (30).

Abstract: Mining method for co-extraction of non-combustible ore and mine methane A method for co-extracting non-combustible ore (e.g., trona) and methane from an underground formation comprising at least one methane-bearing layer and a non-combustible ore bed having a rock roof, comprising: providing a well having a downhole end positioned above the ore bed roof; mining an ore region from an initial cavity and removing the mined ore, thereby creating a subsequent cavity; advancing the mining step to another ore region from the subsequent cavity; allowing the roof of the initial cavity to cave so as to create a gob; repeating the mining, advancing and caving steps, the caving being effective in generating fluid communication between the gob and the well downhole end and in fracturing the methane-bearing layer so as to release methane into the gob; and recovering a gob gas comprising released methane through the well to the surface.

Abstract: The present invention relates to the isolation of carotenoids and in particular the xanthophyll zeaxanthin (zeaxanthin-?,?-Carotene-3,3?-diol) and optionally other carotenoids such as lycopene, ?,?-carotene, 3?-hydroxyechinenone ?-cryptoxanthin and the colourless carotenoids, phytoene and phytofluene from a marine bacterium belonging to the genus Algibacter which is capable of producing the aforementioned compounds. The present invention also provides a strain of Algibacter which is capable of producing significant levels of carotenoids, especially zeaxanthin at high purity, as well as methods of using the Algibacter strain and uses of the carotenoids produced.

Abstract: The present invention relates to a method of screening compounds for modulation and binding to proteins, in particular proteins that have been immobilized in a monolithic chromatographic stationary phase. The method involves observing the conversion of a substrate to product by the protein and determining a product to substrate ratio. Changes in this ratio in the presence of another compound indicates that the other compound is a modulator of the enzyme. Various applications of this method to compound screening, including high throughput screening formats, are described.