Patents by Inventor Richard Hogrefe

Richard Hogrefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triphosphate oligonucleotide modification reagents and uses thereof
    Publication number: 20070179288
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided.
    Type: Application
    Filed: December 11, 2006
    Publication date: August 2, 2007
    Inventors: David Schwartz, Richard Hogrefe
  • Functional biopolymer modification reagents and uses thereof
    Publication number: 20050203289
    Abstract: Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herien. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Application
    Filed: September 8, 2004
    Publication date: September 15, 2005
    Inventors: David Schwartz, Richard Hogrefe