Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.

Abstract: An insertable beehive entrance device allowing entrance into the beehive and disrupting exit from the beehive in order to make the moving of honey bee hives to a new location less problematic. The device includes a base with an entrance opening and a two legs attached to the base forming a triangular frame, the frame forming an entrance at its apex. The frame includes a mesh top covering and a reflective bottom covering configured to be brighter than the inner hive. Once placed in the hive entrance it allows honey bees to enter the hive through the insertable device but disrupts their normal pattern of exit. Bees are now trapped in the hive making it simpler to move. When catching honey bee swarms, this device placed in the entrance makes coming back for the swarm box more convenient.

Abstract: This device was created to make the moving of honey bee hives to a new location less problematic for Bee Keepers. Once placed in the hive entrance it allows honey bees to enter the hive but disrupts their normal pattern of exit. Bees are now trapped in the hive making it simpler to move. When catching honey bee swarms, this device placed in the entrance makes coming back for the swarm box more convenient. Retrieving it can be done at any time of day. This device may also be used to stop honey robbing of a weaker less populated hives. When robber honey bees have been trapped within the hive for three or more days they become acclimated to the established honey bees. This provides more forager bees for the hive making it stronger so it may protect itself from robbing.

Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.

Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.

Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.

Abstract: Marine vessel propulsor occlusion systems and devices made of novel fabrics formed from biodegradable and/or dissolvable materials, and methods of manufacturing and using the same are disclosed. The propulsor occlusion devices can slow and/or incapacitate a marine vessel without serious injury to occupants and without destroying the vessel's propulsion system.

Abstract: A device includes an image sensor, first optics, second optics, and a processor. The first optics are configured to form a first optical pattern (OP) on the image sensor. The first OP is associated with a first wavelength. The second optics are configured to form a second OP on the image sensor. The second OP is associated with a second wavelength that is longer than the first wavelength. The processor is configured to generate a first turbulence estimate based on relative motion of the first OP, to generate a second turbulence estimate based on relative motion of the second OP, and to generate error correction data. The processor is also configured to adjust the first turbulence estimate based on the error correction data and the second turbulence estimate to determine an estimated turbulence value. The processor may also be configured to estimate a wind profile, a turbulence profile, or both.

Abstract: A device includes an image sensor, first optics, second optics, and a processor. The first optics are configured to form a first optical pattern (OP) on the image sensor. The first OP is associated with a first wavelength. The second optics are configured to form a second OP on the image sensor. The second OP is associated with a second wavelength that is longer than the first wavelength. The processor is configured to generate a first turbulence estimate based on relative motion of the first OP, to generate a second turbulence estimate based on relative motion of the second OP, and to generate error correction data. The processor is also configured to adjust the first turbulence estimate based on the error correction data and the second turbulence estimate to determine an estimated turbulence value. The processor may also be configured to estimate a wind profile, a turbulence profile, or both.

Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.

Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.

Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.

Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.

Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.

Abstract: A dock-side cradle for providing a safe point of entry into and out of a personal watercraft such as a canoe or kayak launching and landing same. The cradle is trough-shaped and is open at each end, with a slight slope from one end to the other. Preferably the trough is defined by a plurality of support arms in spaced separation from one another which are connected to a pair of guiding elements. The cradle is adapted to be hingedly connected to a dock so that it can be positioned in the water for use, or rotated up onto the dock when not in use. The cradle is equipped with handrails connecting to the support arms and the support arms themselves may be extendable in order to accommodate varying water levels in relation to the dock. The cradle may be sold as a kit.

Abstract: An apparatus for testing failure of a material used in a jet engine, and more particularly to an apparatus that uses one or more miniature jet engine components made from a material used in a full-size jet engine and desired to be tested. The apparatus permits easy removal and disassembly of a jet engine mounted thereon as well as real-time measurements of run-time parameters. The methods and apparatus provide for predicting and analyzing failure by a number of fatigue-related mechanisms including creep, fatigue, crack growth, foreign object damage, fretting, erosion, and stress corrosion. The apparatus also permits testing of a component placed in the exhaust gases of a jet engine mounted therein.

Abstract: A dock-side cradle for providing a safe point of entry into and out of a personal watercraft such as a canoe or kayak launching and landing same. The cradle is trough-shaped and is open at each end, with a slight slope from one end to the other. Preferably the trough is defined by a plurality of support arms in spaced separation from one another which are connected to a pair of guiding elements. The cradle is adapted to be hingedly connected to a dock so that it can be positioned in the water for use, or rotated up onto the dock when not in use. The cradle is equipped with handrails connecting to the support arms and the support arms themselves may be extendable in order to accommodate varying water levels in relation to the dock. The cradle may be sold as a kit.

Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.