Patents by Inventor Richard Holmes

Richard Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11639514
    Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: May 2, 2023
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
  • Patent number: 11547096
    Abstract: An insertable beehive entrance device allowing entrance into the beehive and disrupting exit from the beehive in order to make the moving of honey bee hives to a new location less problematic. The device includes a base with an entrance opening and a two legs attached to the base forming a triangular frame, the frame forming an entrance at its apex. The frame includes a mesh top covering and a reflective bottom covering configured to be brighter than the inner hive. Once placed in the hive entrance it allows honey bees to enter the hive through the insertable device but disrupts their normal pattern of exit. Bees are now trapped in the hive making it simpler to move. When catching honey bee swarms, this device placed in the entrance makes coming back for the swarm box more convenient.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: January 10, 2023
    Inventor: Richard Holmes
  • Publication number: 20210100223
    Abstract: This device was created to make the moving of honey bee hives to a new location less problematic for Bee Keepers. Once placed in the hive entrance it allows honey bees to enter the hive but disrupts their normal pattern of exit. Bees are now trapped in the hive making it simpler to move. When catching honey bee swarms, this device placed in the entrance makes coming back for the swarm box more convenient. Retrieving it can be done at any time of day. This device may also be used to stop honey robbing of a weaker less populated hives. When robber honey bees have been trapped within the hive for three or more days they become acclimated to the established honey bees. This provides more forager bees for the hive making it stronger so it may protect itself from robbing.
    Type: Application
    Filed: August 18, 2020
    Publication date: April 8, 2021
    Inventor: Richard Holmes
  • Publication number: 20200277643
    Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.
    Type: Application
    Filed: April 10, 2020
    Publication date: September 3, 2020
    Applicant: Leidos, Inc
    Inventors: John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
  • Patent number: 10662457
    Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: May 26, 2020
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
  • Publication number: 20200155966
    Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.
    Type: Application
    Filed: February 16, 2018
    Publication date: May 21, 2020
    Applicant: Leidos, Inc.
    Inventors: John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
  • Patent number: 10315749
    Abstract: Marine vessel propulsor occlusion systems and devices made of novel fabrics formed from biodegradable and/or dissolvable materials, and methods of manufacturing and using the same are disclosed. The propulsor occlusion devices can slow and/or incapacitate a marine vessel without serious injury to occupants and without destroying the vessel's propulsion system.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: June 11, 2019
    Assignee: Leidos, Inc.
    Inventors: Howard Walker, Scott Stewart, Richard Holmes Griffey
  • Patent number: 10281483
    Abstract: A device includes an image sensor, first optics, second optics, and a processor. The first optics are configured to form a first optical pattern (OP) on the image sensor. The first OP is associated with a first wavelength. The second optics are configured to form a second OP on the image sensor. The second OP is associated with a second wavelength that is longer than the first wavelength. The processor is configured to generate a first turbulence estimate based on relative motion of the first OP, to generate a second turbulence estimate based on relative motion of the second OP, and to generate error correction data. The processor is also configured to adjust the first turbulence estimate based on the error correction data and the second turbulence estimate to determine an estimated turbulence value. The processor may also be configured to estimate a wind profile, a turbulence profile, or both.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: May 7, 2019
    Assignee: THE BOEING COMPANY
    Inventors: Ralph Galetti, Teresa Neudecker, Richard Holmes, Jeremy Manning, Robert Fetner, III, Angel Portillo
  • Publication number: 20180259549
    Abstract: A device includes an image sensor, first optics, second optics, and a processor. The first optics are configured to form a first optical pattern (OP) on the image sensor. The first OP is associated with a first wavelength. The second optics are configured to form a second OP on the image sensor. The second OP is associated with a second wavelength that is longer than the first wavelength. The processor is configured to generate a first turbulence estimate based on relative motion of the first OP, to generate a second turbulence estimate based on relative motion of the second OP, and to generate error correction data. The processor is also configured to adjust the first turbulence estimate based on the error correction data and the second turbulence estimate to determine an estimated turbulence value. The processor may also be configured to estimate a wind profile, a turbulence profile, or both.
    Type: Application
    Filed: April 19, 2017
    Publication date: September 13, 2018
    Inventors: Ralph Galetti, Teresa Neudecker, Richard Holmes, Jeremy Manning, Robert Fetner, III, Angel Portillo
  • Patent number: 9908064
    Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: March 6, 2018
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
  • Publication number: 20160230203
    Abstract: A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation. The bioreactor utilizes lysates from engineered eukaryotic (e.g., yeast) or prokaryotic (e.g., bacterial) strains that contain factors for protein folding and posttranslational modifications. Combination of various purification modules on the same fluidic platform allows flexibility of re-routing for purification of different proteins depending on specific target requirements.
    Type: Application
    Filed: January 29, 2016
    Publication date: August 11, 2016
    Applicant: Leidos, Inc.
    Inventors: John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
  • Patent number: 9178096
    Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: November 3, 2015
    Assignee: Leidos, Inc.
    Inventors: John Paul Ziegler, Howard Walter Walker, Richard Holmes Griffey, Newell Convers Wyeth
  • Publication number: 20150287864
    Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.
    Type: Application
    Filed: October 15, 2014
    Publication date: October 8, 2015
    Inventors: John Paul Ziegler, Howard Walter Walker, Richard Holmes Griffey, Newell Convers Wyeth
  • Patent number: 8866001
    Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: October 21, 2014
    Assignee: Leidos, Inc.
    Inventors: John Paul Ziegler, Howard Walter Walker, Richard Holmes Griffey, Newell Convers Wyeth
  • Publication number: 20120152007
    Abstract: An apparatus for testing failure of a material used in a jet engine, and more particularly to an apparatus that uses one or more miniature jet engine components made from a material used in a full-size jet engine and desired to be tested. The apparatus permits easy removal and disassembly of a jet engine mounted thereon as well as real-time measurements of run-time parameters. The methods and apparatus provide for predicting and analyzing failure by a number of fatigue-related mechanisms including creep, fatigue, crack growth, foreign object damage, fretting, erosion, and stress corrosion. The apparatus also permits testing of a component placed in the exhaust gases of a jet engine mounted therein.
    Type: Application
    Filed: August 29, 2011
    Publication date: June 21, 2012
    Inventors: Richard Holmes, Robert G. Tryon, II, John E. Pope, Michael Oja, Animesh Dey, Jesse Hamler, Jonathan Brooks, James Tryon, Daniel A. Nasser, A. Lorenz Nasser
  • Patent number: 8006544
    Abstract: An apparatus for testing failure of a material used in a jet engine, and more particularly to an apparatus that uses one or more model jet engine components made from a material used in a full-size jet engine and desired to be tested. The apparatus permits easy removal and disassembly of a jet engine mounted thereon as well as real-time measurements of run-time parameters. The methods and apparatus provide for predicting and analysing failure by a number of fatigue-related mechanisms including creep, fatigue, crack growth, foreign object damage, fretting, erosion, and stress corrosion.
    Type: Grant
    Filed: January 14, 2008
    Date of Patent: August 30, 2011
    Assignee: Vextec Corporation
    Inventors: Richard Holmes, Robert G. Tryon, III, John E. Pope, Daniel A. Nasser, Michael Oja, Animesh Dey, Jesse Hamler, Jonathan Brooks, James Tryon
  • Publication number: 20110167459
    Abstract: Apparatus and method for distributing broadcast data signals comprising broadcast receiving means for receiving satellite data signals, and converting the modulation of the data signals from a first scheme compatible with satellite set-top boxes into a more spectrally efficient second scheme, the data signals then being distributed to one or more satellite set-top boxes, wherein adapter means are provided for at least one satellite set-top box to convert the modulation of the data signals from the second scheme to the first scheme.
    Type: Application
    Filed: January 7, 2011
    Publication date: July 7, 2011
    Inventor: Richard Holme
  • Patent number: 7953651
    Abstract: A computer-implemented method for validating updated business rules. A first set of documents utilized to validate a first set of business rules is provided. A second set of business rules generated from an update of the first set of business rules is received. Each business rule includes input parameters. A second set of documents is received. A template file includes the input parameters and corresponding path expressions. An augmented set of documents includes the first and second sets of documents. The second set of business rules is automatically semantically validated against the augmented set of documents. The semantic validation includes executing the second set of business rules with each document of the augmented set. The executing includes binding, via the path expressions, the input parameters to values included in a document of the augmented set.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: May 31, 2011
    Assignee: International Business Machines Corporation
    Inventors: Isaac Kam-Chak Cheng, Scott Richard Holmes, Vikas Krishna
  • Patent number: 7542970
    Abstract: A selection system and method. The selection method comprises receiving, by a computing system, a taxonomy of data related to a specified domain of knowledge on the web. A taxonomy tree is constructed from the taxonomy. A sub tree related to a sub-domain from specified domain is selected from the taxonomy tree. A first list comprising user expected universal resource locators (URLs) related to the sub-domain is received. A second list comprising topic expressions defining each node of the taxonomy sub-tree is generated. A query based on the second list is generated. The query is applied on an index of URLs generated from a web crawling process to generate a third list. A recall value is calculated based on the first list and the third list.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: June 2, 2009
    Assignee: International Business Machines Corporation
    Inventors: Scott Richard Holmes, Hongcheng Mi, Sumit Negi, Zengyan Zhang
  • Patent number: RE46584
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: October 24, 2017
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Holmes Griffey