Patents by Inventor Richard Hoogenboom

Richard Hoogenboom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11332554
    Abstract: The invention entails the combination of basic catalysts, specifically guanidine-based catalysts, such as TBD, in conjunction with functionalized amines having a hydrogen bond donating or accepting functionality, to facilitate the accelerated transamidation of polymer compounds with non-activated ester side chains.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: May 17, 2022
    Assignee: Universiteit Gent
    Inventors: Richard Hoogenboom, Joachim Van Guyse
  • Patent number: 11293138
    Abstract: The present invention provides a post-fabrication modification approach for the fabrication of colored and chromic materials and sensors using plasma surface modification to covalently bind the coloring agent to the substrate, thus avoiding leaching of the dye. Advantageously, in said methods, said coloring agent is a dye or pigment linked to a radical sensitive functional group, such as an alkenyl or alkynyl functional group, and is applied to the substrate prior to the gas plasma treatment. The methods envisaged herein are generic in nature, which allow the covalent immobilization of various dyes on different materials. The covalently coated materials after plasma surface modification, particularly the covalently coated chromic materials and sensors, can be used in many different applications, such as protective textile and wound dressing applications.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 5, 2022
    Assignee: UNIVERSITEIT GENT
    Inventors: Richard Hoogenboom, Gertjan Vancoillie
  • Publication number: 20220010068
    Abstract: The present invention, in general, relates to the field of poly(2-oxazolines) (PAOx), more in particular poly(2-methoxymethyl-2-oxazoline) (PMeOMeOX) and poly(2-dimethylamino-2-oxazoline) (PDMAOx). The present invention also provides methods for preparing these PAOx, as well as compositions and uses comprising said PAOx.
    Type: Application
    Filed: November 14, 2019
    Publication date: January 13, 2022
    Inventors: Richard Hoogenboom, Ondrej Sedlacek
  • Publication number: 20210206889
    Abstract: The invention entails the combination of basic catalysts, specifically guanidine-based catalysts, such as TBD, in conjunction with functionalized amines having a hydrogen bond donating or accepting functionality, to facilitate the accelerated transamidation of polymer compounds with non-activated ester side chains.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 8, 2021
    Inventors: Richard Hoogenboom, Joachim Van Guyse
  • Patent number: 10925996
    Abstract: A biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent is disclosed. The EL-POX comprises m electrophilic groups; and the nucleophilic cross-linking agent comprises n nucleophilic groups, wherein the m electrophilic groups are capable of reacting with the n nucleophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m?3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. Biocompatible medical products and kits comprising the cross-linked POX-polymers are also disclosed.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: February 23, 2021
    Assignee: GATT TECHNOLOGIES BV
    Inventors: Richard Hoogenboom, Johannes Caspar Mathias Elizabeth Bender, Jan Cornelis Maria Van Hest
  • Publication number: 20210015926
    Abstract: The present invention relates to polyoxazoline polymers, polymer combinations and compositions comprising those polymers or combinations of polymers. The invention further relates to the use of said polyoxazoline polymers, said combinations and compositions comprising such polymers and combinations for the sustained release of one or more active ingredients, in particular one or more active pharmaceutical ingredients. It further relates to the use of polyoxazoline polymers or polymer combinations as drug carrier.
    Type: Application
    Filed: March 18, 2019
    Publication date: January 21, 2021
    Applicant: Universiteit Gent
    Inventors: Maarten Vergaelen, Richard Hoogenboom, Victor Retamero de la Rosa, Chris Vervaet, Aseel Samaro, Valérie Vanhoorne
  • Patent number: 10889685
    Abstract: Cyclic imino ether polymers, such as polyoxazolines or polyoxazines, having a low polydispersity index can be obtained in a tubular flow reactor by applying a sufficiently high linear flow velocity of the reaction mixture in the tubular flow reactor, such as a flow velocity of least 100 cm/min or at least 120 cm/min. Also, methods to control the polydispersity of a cyclic imino ether polymer during polymerization are provided.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: January 12, 2021
    Assignees: Universiteit Gent, Universiteit Hasselt
    Inventors: Victor Retamero De La Rosa, Evelien Baeten, Richard Hoogenboom, Tanja Junkers
  • Patent number: 10869930
    Abstract: The invention relates to invention relates to a statistical copolymer represented by the following formula (I): Ini-[Ox]m-[Oz]n-Nuc (I) wherein: Ini represents a residue of an initiator of cationic polymerization, Nuc represents a residue of a nucleophilic agent, Ox represents N(R1)CHRaCHRa; each R1 independently represents H or C(O)R11; and R11 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; Oz represents N(R2)CHRaCHRaCHRa; each R2 independently represents C(O)R21 or H; and R21 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; each Ra independently represents H, linear or branched C1-3 alkyl; m?5; n?5; m+n?20; 3:97?m:n?97:3.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: December 22, 2020
    Assignee: UNIVERSITEIT GENT
    Inventors: Richard Hoogenboom, Bart Verbraeken
  • Patent number: 10781287
    Abstract: A method for production of a uniform polymer of high molar mass is provides, the method comprising: (a) polymerizing cyclic imino ether monomer in a first reaction mixture by cationic ring opening polymerization to produce a polymerized first reaction mixture containing (i) polymerized material and (ii) solvent and/or unreacted cyclic imino ether monomer; (b) separating solvent and/or unreacted cyclic imino ether monomer from polymerized material contained in the polymerized first reaction mixture; (c) copolymerizing by cationic ring opening polymerization a second liquid reaction mixture containing cyclic imino ether monomer and solvent by combining the separated unreacted cyclic imino ether monomer and/or the separated solvent with other components. Also disclosed are polyoxazoline polymers comprising at least 50 wt.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: September 22, 2020
    Assignee: UNIVERSITEIT GENT
    Inventors: Richard Hoogenboom, Bryn Monnery
  • Publication number: 20200246472
    Abstract: The present invention provides peptide hydrogelators capable of forming hydrogels as carriers of active ingredients and acting as sustained or controlled release drug delivery systems.
    Type: Application
    Filed: February 16, 2017
    Publication date: August 6, 2020
    Inventors: Charlotte Martin, Annemieke Madder, Steven Ballet, Richard Hoogenboom
  • Publication number: 20200199289
    Abstract: The present disclosure relates to the surface modification of substrates using poly (2-oxazine)s. Specifically, the present disclosure provides the use one or more poly(2-alkyl-2-oxazine) or copolymers containing poly(2-alkyl-2-oxazine) in surface modification of a substrate. More in particular the present disclosure provides substrates having attached thereto, or associated therewith, one or more poly(2-alkyl-2-oxazine) or copolymers containing poly(2-alkyl-2-oxazine); wherein said alkyl is preferentially selected from the list comprising methyl and ethyl. The present disclosure also provides methods for preparing such substrates and uses thereof.
    Type: Application
    Filed: December 19, 2019
    Publication date: June 25, 2020
    Inventors: Richard Hoogenboom, Bart Verbraeken, Edmondo Benetti
  • Publication number: 20200148823
    Abstract: Cyclic imino ether polymers, such as polyoxazolines or polyoxazines, having a low polydispersity index can be obtained in a tubular flow reactor by applying a sufficiently high linear flow velocity of the reaction mixture in the tubular flow reactor, such as a flow velocity of least 100 cm/min or at least 120 cm/min. Also, methods to control the polydispersity of a cyclic imino ether polymer during polymerization are provided.
    Type: Application
    Filed: April 21, 2017
    Publication date: May 14, 2020
    Inventors: Victor Retamero De La Rosa, Evelien Baeten, Richard Hoogenboom, Tanja Junkers
  • Patent number: 10526371
    Abstract: Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a ?3- or ?2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: January 7, 2020
    Assignees: Universiteit Gent, Vrije Universiteit Brussel
    Inventors: Richard Hoogenboom, Annemieke Madder, Steven Ballet
  • Publication number: 20190231923
    Abstract: A biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent is disclosed. The EL-POX comprises m electrophilic groups; and the nucleophilic cross-linking agent comprises n nucleophilic groups, wherein the m electrophilic groups are capable of reacting with the n nucleophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m?3; and wherein to the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. Biocompatible medical products and kits comprising the cross-linked POX-polymers are also disclosed.
    Type: Application
    Filed: April 8, 2019
    Publication date: August 1, 2019
    Applicant: GATT Technologies B.V.
    Inventors: Richard HOOGENBOOM, Johannes Caspar Mathias Elizabeth BENDER, Jan Cornelis Maria VAN HEST
  • Publication number: 20190231889
    Abstract: The invention relates to invention relates to a statistical copolymer represented by the following formula (I): Ini-[Ox]m-[Oz]n-Nuc (I) wherein: Ini represents a residue of an initiator of cationic polymerization, Nuc represents a residue of a nucleophilic agent, Ox represents N(R1)CHRaCHRa; each R1 independently represents H or C(O)R11; and R11 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; Oz represents N(R2)CHRaCHRaCHRa; each R2 independently represents C(O)R21 or H; and R21 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; each Ra independently represents H, linear or branched C1-3 alkyl; m?5; n?5; m+n?20; 3:97?m:n?97:3.
    Type: Application
    Filed: July 3, 2017
    Publication date: August 1, 2019
    Applicant: UNIVERSITEIT GENT
    Inventors: Richard HOOGENBOOM, Bart VERBRAEKEN
  • Patent number: 10314936
    Abstract: A biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-PDX) with a nucleophilic cross-linking agent is disclosed. The EL-PDX comprises m electrophilic groups; and the nucleophilic cross-linking agent comprises n nucleophilic groups, wherein the m electrophilic groups are capable of reacting with the n nucleophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m?3; and wherein the EL-PDX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. Biocompatible medical products and kits comprising the cross-linked PDX-polymers are also disclosed.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: June 11, 2019
    Assignee: GATT TECHNOLOGIES BV
    Inventors: Richard Hoogenboom, Johannes Caspar Mathias Elizabeth Bender, Jan Cornelis Maria Van Hest
  • Publication number: 20190032277
    Abstract: The present invention provides a post-fabrication modification approach for the fabrication of colored and chromic materials and sensors using plasma surface modification to covalently bind the coloring agent to the substrate, thus avoiding leaching of the dye. Advantageously, in said methods, said coloring agent is a dye or pigment linked to a radical sensitive functional group, such as an alkenyl or alkynyl functional group, and is applied to the substrate prior to the gas plasma treatment. The methods envisaged herein are generic in nature, which allow the covalent immobilization of various dyes on different materials. The covalently coated materials after plasma surface modification, particularly the covalently coated chromic materials and sensors, can be used in many different applications, such as protective textile and wound dressing applications.
    Type: Application
    Filed: January 19, 2017
    Publication date: January 31, 2019
    Applicant: UNIVERSITEIT GENT
    Inventors: Richard HOOGENBOOM, Gertjan VANCOILLIE
  • Publication number: 20180346649
    Abstract: A method for production of a uniform polymer of high molar mass is provides, the method comprising: (a) polymerizing cyclic imino ether monomer in a first reaction mixture by cationic ring opening polymerization to produce a polymerized first reaction mixture containing (i) polymerized material and (ii) solvent and/or unreacted cyclic imino ether monomer; (b) separating solvent and/or unreacted cyclic imino ether monomer from polymerized material contained in the polymerized first reaction mixture; (c) copolyerizing by cationic ring opening polymerization a second liquid reaction mixture containing cyclic imino ether monomer and solvent by combining the separated unreacted cyclic imino ether monomer and/or the separated solvent with other components. Also disclosed are polyoxazoline polymers comprising at least 50 wt.
    Type: Application
    Filed: August 2, 2018
    Publication date: December 6, 2018
    Applicant: Universiteit Gent
    Inventors: Richard HOOGENBOOM, Bryn MONNERY
  • Patent number: 10118991
    Abstract: A method for production of a uniform polymer of high molar mass is provides, the method comprising: (a) polymerizing cyclic imino ether monomer in a first reaction mixture by cationic ring opening polymerization to produce a polymerized first reaction mixture containing (i) polymerized material and (ii) solvent and/or unreacted cyclic imino ether monomer; (b) separating solvent and/or unreacted cyclic imino ether monomer from polymerized material contained in the polymerized first reaction mixture; (c) copolyerizing by cationic ring opening polymerization a second liquid reaction mixture containing cyclic imino ether monomer and solvent by combining the separated unreacted cyclic imino ether monomer and/or the separated solvent with other components. Also disclosed are polyoxazoline polymers comprising at least 50 wt.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: November 6, 2018
    Assignee: UNIVERSITEIT GENT
    Inventors: Richard Hoogenboom, Bryn Monnery
  • Patent number: 10029020
    Abstract: Provided herein are fullerene compositions, and methods of preparing fullerene compositions. More particularly, the fullerene compositions include a fullerene-polymer complex having a fullerene and a non-conjugated hydrophilic or amphiphilic polymer. The non-conjugated polymer is substituted with a substituent having a functional group capable of forming intermolecular interactions with the fullerene via pi-stacking.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: July 24, 2018
    Assignee: Universiteit Gent
    Inventors: Richard Hoogenboom, Joachim Van Guyse, Victor Retamero De La Rosa