Patents by Inventor Richard Horuk

Richard Horuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030003447
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 2, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Piperazine derivatives and their use as anti-inflammatory agents
    Publication number: 20020177598
    Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Application
    Filed: November 29, 2000
    Publication date: November 28, 2002
    Applicant: Schering Aktiengschellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Patent number: 6475718
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: November 5, 2002
    Assignees: Schering Aktiengesellschaft, The Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Radiopharmaceuticals for diagnosing alzheimer's disease
    Publication number: 20020131932
    Abstract: This invention is directed to the use of radiopharmaceuticals in diagnosing Alzheimer's disease. In particular the radiopharmaceuticals of the invention are able to pass through the blood-brain barrier and bind to the CCR1 receptor present in brain tissue of patients having Alzheimer's disease.
    Type: Application
    Filed: November 6, 2001
    Publication date: September 19, 2002
    Applicant: Schering AG
    Inventors: Christoph-Stephan Hilger, Bernd Johannsen, Joerg Steinbach, Peter Maeding, Meredith Halks-Miller, Richard Horuk, Harald Dinter, Raju Mohan, Joseph E. Hesselgesser
  • METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN THE APJ RECEPTOR AND THE HIV VIRUS
    Publication number: 20020062488
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: September 8, 1998
    Publication date: May 23, 2002
    Inventors: ROBERT W. DOMS, DARYL FAULDS, JOSEPH E. HESSELGESSER, RICHARD HORUK, BRANISLAVA MITROVIC, YIQING ZHOU
  • Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
    Publication number: 20020039997
    Abstract: This invention is directed to pharmaceutical compositions useful in treating heart transplant rejection in mammals comprising a pharmaceutically acceptable excipient, a therapeutically effective amount of a non-peptide CCR1 receptor antagonist and a sub-nephrotoxic amount of cyclosporin A.
    Type: Application
    Filed: July 25, 2001
    Publication date: April 4, 2002
    Inventor: Richard Horuk
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 6207665
    Abstract: This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: March 27, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Guo Ping Wei, Wei Xu, Wei Zheng