Patents by Inventor Richard Huang
Richard Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240076498Abstract: Asphalt binders and related methods and uses are provided. In some embodiments, the asphalt binder is produced by: providing a high-asphaltene content petroleum feedstock; performing solvent deasphalting on the feedstock to produce a partially deasphalted oil and an asphaltene-rich residue; and collecting the partially deasphalted oil (DAO). The high-asphaltene content petroleum feedstock may comprise residue from vacuum distillation or flash separation of extra heavy oil or bitumen, or recycled asphalt. The DAO may itself be used as the asphalt binder or may be a component of a blend with the original feedstock. Asphalt binders may also be produced by blending residue and heavy distillate produced from vacuum distillation or flash separation, with DAO or the asphaltene-rich residue of the solvent deasphalting process. The disclosed methods allow for production of asphalt binders of a wide variety of performance grades.Type: ApplicationFiled: September 6, 2023Publication date: March 7, 2024Applicant: InnoTech Alberta Inc.Inventors: Kasra Nikooyeh, Thomas Kaminski, Richard McFarlane, Haibo Huang, John Bleile, James Donald, Monika Dul
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Patent number: 11922157Abstract: In one embodiment, a system for managing communication connections in a virtualization environment includes a plurality of host machines implementing a virtualization environment, wherein each of the host machines includes a hypervisor, at least one user virtual machine (user VM), and a distributed file server that includes file server virtual machines (FSVMs) and associated local storage devices. Each FSVM and associated local storage device are local to a corresponding one of the host machines, and the FSVMs conduct I/O transactions with their associated local storage devices based on I/O requests received from the user VMs. Each of the user VMs on each host machine sends each of its representative I/O requests to an FSVM that is selected by one or more of the FSVMs for each I/O request based on a lookup table that maps a storage item referenced by the I/O request to I/O the selected one of the FSVMs.Type: GrantFiled: September 21, 2021Date of Patent: March 5, 2024Assignee: Nutanix, Inc.Inventors: Richard James Sharpe, Kalpesh Ashok Bafna, Durga Mahesh Arikatla, Shyamsunder Prayagchand Rathi, Satyajit Sanjeev Deshmukh, Vishal Sinha, Anil Kumar Gopalapura Venkatesh, Rashmi Gupta, Rishabh Sharma, Yifeng Huang
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Patent number: 11902280Abstract: Systems and methods for Internet access control are presented. A third-party application is hosted by a third-party server on the Internet. The third-party application has third-party data of a user. An Internet access control device detects an Internet access by the user to a target server on the Internet. The Internet access control device allows or blocks the Internet access depending on whether the Internet access is permitted or prohibited based on the third-party data.Type: GrantFiled: July 23, 2021Date of Patent: February 13, 2024Assignee: Trend Micro IncorporatedInventors: Charles Hung-Ching Cheng, Cheng-Lin Hou, Chinghsien Liao, Hua-Lung Richard Huang
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Publication number: 20240024829Abstract: Disclosed are techniques to mimic turbulent-enhanced reactivity under confinement by the addition of dilute high molecular weight polymers. Micro-scale imaging within a transparent porous medium reveals an elastic instability (EI), which drives chaotic fluctuations that stretch and fold solute blobs exponentially in time analogous to turbulent Batchelor mixing, despite the low Re. A reduction in the required mixing length can be observed, suggesting a cooperation between the elastic instability and the dispersion inherent to the disordered 3D porous media—which can be modeled as additive independent mixing rates, representing a dramatic conceptual simplification. The disclosed enhanced transport of solutes circumvents the traditional trade-off between throughput and reactor length, allowing a simultaneous large reduction in length and increases in throughput.Type: ApplicationFiled: July 12, 2023Publication date: January 25, 2024Applicant: The Trustees of Princeton UniversityInventors: Sujit Datta, Christopher Browne, Richard Huang, Callie Zheng
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Patent number: 11878965Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.Type: GrantFiled: December 21, 2021Date of Patent: January 23, 2024Assignee: Gilead Sciences, Inc.Inventors: Daniel H. Byun, Zhenhong R. Cai, Eda Y. Canales, Laurent P. Debien, Timothy R. Hansen, Richard Huang, Petr Jansa, Rick A. Lee, Jennifer A. Loyer-Drew, Ryan McFadden, Michael L. Mitchell, Hyung-Jung Pyun, Roland D. Saito, Michael S. Sangi, Adam J. Schrier, Marina E. Shatskikh, James G. Taylor, Joshua J. Van Veldhuizen, Lianhong Xu
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Publication number: 20230382992Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.Type: ApplicationFiled: February 27, 2023Publication date: November 30, 2023Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard HUANG, Guodong CHEN, Michelle KUHNE, Hong-An TRUONG
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Patent number: 11802162Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: GrantFiled: October 25, 2019Date of Patent: October 31, 2023Assignee: Bristol-Myers Squibb CompanyInventors: Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla A. Henning, Michelle Minhua Han, Guodong Chen, Richard Huang, Indrani Chakraborty, Haichun Huang, Susan Wong, Huiming Li
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Publication number: 20230090053Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.Type: ApplicationFiled: December 21, 2021Publication date: March 23, 2023Inventors: Daniel H. Byun, Zhenhong R. Cai, Eda Y. Canales, Laurent P. Debien, Timothy R. Hansen, Richard Huang, Petr Jansa, Rick A. Lee, Jennifer A. Loyer-Drew, Ryan McFadden, Michael L. Mitchell, Hyung-Jung Pyun, Roland D. Saito, Michael S. Sangi, Adam J. Schrier, Marina E. Shatskikh, James G. Taylor, Joshua J. Van Veldhuizen, Lianhong Xu
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Patent number: 11591392Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.Type: GrantFiled: November 27, 2019Date of Patent: February 28, 2023Assignee: Bristol-Myers Squibb CompanyInventors: Xiao Min Schebye, Mark J. Selby, Michelle Minhua Han, Christine Bee, Andy X. Deng, Anan Chuntharapai, Brigitte Devaux, Huiming Li, Paul O. Sheppard, Alan J. Korman, Daniel F. Ardourel, Ekaterina Deyanova, Richard Huang, Guodong Chen, Michelle Kuhne, Hong-An Truong
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Publication number: 20230050665Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: ApplicationFiled: June 30, 2021Publication date: February 16, 2023Inventors: Changyu WANG, Nils LONBERG, Alan J. KORMAN, Mark J. SELBY, Mohan SRINIVASAN, Karla HENNING, Michelle Minhua HAN, Guodong CHEN, Richard HUANG, Indrani CHAKRABORTY, Haichun HUANG, Susan WONG, Huiming LI
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Publication number: 20230051701Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.Type: ApplicationFiled: May 5, 2022Publication date: February 16, 2023Inventors: Nils Lonberg, Alan J. Korman, Bryan C. Barnhart, Aaron P. Yamniuk, Mohan Srinivasan, Karla A. Henning, Ming Lei, Emanuela Sega, Angela Goodenough, Maria N. Jure-Kunkel, Guodong Chen, John S. Sack, Richard Huang, Martin J. Corbett, Joseph E. Myers, JR., Liang Schweizer, Sandra V. Hatcher, Haichun Huang, Pingping Zhang
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Publication number: 20220093211Abstract: Detecting cross-contamination between test samples used for determining cancer in a subject is beneficial. To detect cross-contamination, test sequences including at least one single nucleotide polymorphism are prepared using genome sequencing techniques. Some of the test sequences can be filtered to improve accuracy and precision. A prior contamination probability for each test sequence is determined based on a minor allele frequency. A contamination model including a likelihood test is applied to a test sequence. The likelihood test obtains a current contamination probability representing the likelihood that the test sample is contaminated. The contamination model can also determine a likelihood that the sample includes loss of heterozygosity representing the likelihood that the test sequence is contaminated. Test samples that are contaminated are removed. A source for the contaminated test sample can be found by comparing contaminated test sequences to other test sequences.Type: ApplicationFiled: September 17, 2021Publication date: March 24, 2022Inventors: ONUR SAKARYA, CHRISTOPHER-JAMES A.V. YAKYM, PRANAV PARMJIT SINGH, ROBERT ABE PAINE CALEF, RICHARD HUANG
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Patent number: 11211354Abstract: In an embodiment, a system includes: a circular frame comprising a first side and a second side opposite the first side, wherein the circular frame comprises an aperture formed therethrough; an insert disposed within the aperture; a first wafer disposed over the insert; a second wafer disposed over the first wafer, wherein both the first wafer and the second wafer are configured for eutectic bonding when heated; two clamps disposed on the first side along the circular frame, wherein the two clamps are configured to contact the second wafer at respective clamp locations; and a plurality of pieces configured to secure the insert within the aperture, the plurality of pieces comprising both fixed and flexible pieces, the plurality of pieces comprising two fixed pieces disposed respectively adjacent to the clamp locations along the second side of the circular frame.Type: GrantFiled: November 28, 2018Date of Patent: December 28, 2021Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.Inventors: Chih-Hang Chang, Richard Huang, I-shi Wang, Yin-Tun Chou, Jen-Hao Liu
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Patent number: 11084881Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.Type: GrantFiled: September 23, 2019Date of Patent: August 10, 2021Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla Henning, Michelle Minhua Han, Guodong Chen, Richard Huang, Indrani Chakraborty, Haichun Huang, Susan Wong, Huiming Li
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Publication number: 20210178403Abstract: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.Type: ApplicationFiled: September 15, 2020Publication date: June 17, 2021Inventors: Lotien Richard Huang, Thomas A. Barber, Bruce L. Carvalho, Ravi Kapur, Paul Vernucci, Mehmet Toner, Zihua Wang
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Patent number: 10856568Abstract: A device including a water chamber for filtering smoke or vapor prior to inhalation of the smoke or vapor. The device including a vaporization chamber that contains a substance to be heated or burned. The device including an air flow chamber, herein the air flow chamber connects the vaporization chamber, wherein the air flow chamber is configured to provide a tunnel between an upper edge and a lower edge of the air flow chamber, for passage of air/vapor from an air/vapor entry port to a filtered air exit port for air/vapor at the water chamber, in a snake like manner; wherein the air/vapor entry port is located at a point where the vaporization chamber is joined to the water chamber. The air flow chamber is configured to prevent leakage of water from the water chamber to the vaporization chamber.Type: GrantFiled: May 11, 2017Date of Patent: December 8, 2020Inventor: Yao Tien Richard Huang
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Patent number: 10805275Abstract: A method in an internet server for implementing internet service, the method including exclusively binding a first socket handle object of a first process with a first port. The method also includes generating a first child process from the first process and creating a first duplicate socket handle of the first socket handle object in a first file, the first file being associated with an id of the first child process. The method further includes forming, using the first child process, a first child socket handle object from the first duplicate socket handle in the first file, thereby causing the first child socket handle object to be associated with the first port.Type: GrantFiled: August 21, 2019Date of Patent: October 13, 2020Assignee: Trend Micro IncorporatedInventor: Hua-Lung Richard Huang
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Patent number: 10786817Abstract: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.Type: GrantFiled: April 27, 2018Date of Patent: September 29, 2020Assignees: The General Hospital Corporation, GPB Scientific, LLCInventors: Lotien Richard Huang, Thomas A. Barber, Bruce L. Carvalho, Ravi Kapur, Paul Vernucci, Mehmet Toner, Zihua Wang
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Patent number: 10757955Abstract: Included in the present invention are a method for preparing tealeaf extracts having different tastes, and a beverage prepared using extracts made by the method. The method involves adding tealeaves to an extraction column, performing continuous extraction using water at 5° C.-140° C. at a flow rate of 20-200 mL/min, collecting liquid extracts in sections, and drawing a relative taste intensity curve; and according to a taste variation shown in the relative taste intensity curve, recombining collected liquid extracts of different sections. The method of the present invention can produce tealeaf extracts having high grade taste and high concentration without the need for a concentration step, the extraction yield is high, and the sensory attributes of the tealeaf extracts can be rebalanced in a very flexible manner, so as to obtain beverages of different tastes.Type: GrantFiled: October 22, 2015Date of Patent: September 1, 2020Assignee: THE COCA-COLA COMPANYInventors: Xiaogen Yang, Gooden Wei, Richard Huang, Amy Song
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Patent number: D918164Type: GrantFiled: November 12, 2020Date of Patent: May 4, 2021Assignee: Crestron Electronics, Inc.Inventors: Srinivas Vunnava, Dao Phan, Michael Fonti, Richard Huang