Patents by Inventor Richard I. Duclos, Jr.

Richard I. Duclos, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Se-Adenosyl-L-Selenohomocysteine Selenoxide As A Modulator Of Methyltransferase And Other Activities
    Publication number: 20160090397
    Abstract: The invention relates to a compound of the structural formula or a hydrate or an isotope thereof. The invention also relates to a preparation method thereof and methods of providing dietary organoselenium, inactivating an enzyme, modulating the activity of a protein (e.g., methyltransferase) or nucleic acid, identifying a methyltransferase that reacts with compound, and oxidizing a methyltransferase-reactive substrate.
    Type: Application
    Filed: September 30, 2015
    Publication date: March 31, 2016
    Inventors: Zhaohui Sunny Zhou, Richard I. Duclos, JR., Dillon C. Cleary, Kalli C. Catcott
  • NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF
    Publication number: 20150099800
    Abstract: The invention provides for novel lipase inhibitors, and compositions and devices comprising the same. The invention further provides for methods for treatment of disorders comprising administration of novel diacylglycerol lipase inhibitors, and compositions and devices comprising said inhibitors. In some embodiments, the disorders are pancreatitis, obesity, shock or pancreatic necrosis. The invention further provides for novel ether lipid reporter compounds and methods of assaying enzymatic activity comprising contacting a compound with a novel ether lipid reporter compound.
    Type: Application
    Filed: May 24, 2013
    Publication date: April 9, 2015
    Inventor: Richard I. Duclos, JR.
  • Phospholipid compounds and use therefor
    Patent number: 5744459
    Abstract: The compound of the present invention comprises a substituted lysophospholipid, which includes a C12 to C20 alkyl ether, a C12 to C20 thioether, or a substituted C3 to C6 heterocycle containing at least two ring heteroatoms, selected from the group consisting of nitrogen, oxygen, sulfur and combinations thereof; and also includes a choline group or a C4 to C7 heterocycle containing heteroatoms selected from the group consisting of nitrogen, oxygen, sulfur and combinations thereof. The compounds of this invention possess antineoplastic and immunomodulatory characteristics.
    Type: Grant
    Filed: February 5, 1996
    Date of Patent: April 28, 1998
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Richard I. Duclos, Jr., Donna J. Fournier
  • Phospholipid compounds and use therefor
    Patent number: 5489580
    Abstract: Novel compounds and use therefor in treating neoplastic and immune system disorders are disclosed. The compound of the present invention comprises a substituted lysophospholipid, which includes a C12 to C20 alkyl ether, a C12 to C20 thioether, or a substituted C3 to C6 heterocycle containing at least two ring heteroatoms, selected from the group consisting of nitrogen, oxygen, sulfur and combinations thereof; and also includes a choline group or a C4 to C7 heterocycle containing heteroatoms selected from the group consisting of nitrogen, oxygen, sulfur and combinations thereof.The method for treating neoplastic or immune system disorders includes administering an effective dose of a compound of the present invention in a therapeutic manner. Effective doses of these compounds result in cytotoxic effects upon various leukemic cell lines.The compounds of this invention have the advantage that these compounds possess antineoplastic and immunomodulatory characteristics.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: February 6, 1996
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Richard I. Duclos, Jr., Donna J. Fournier