Patents by Inventor Richard I. Hogrefe

Richard I. Hogrefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220289786
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 15, 2022
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Patent number: 11414453
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: August 16, 2022
    Assignee: TriLink Biotechnologies, LLC
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Publication number: 20210395729
    Abstract: The present invention includes compositions and methods for the treatment of a medical condition or disease utilizing editing oligonucleotides. The editing oligonucleotides contain a an oligonucleotide strand of about 10 to about 50 nucleotides on each side of the editing moiety which may contain a sugar or linker that positions the active editing moiety in the proper location for hybridization to the target nucleic acid. The editing oligonucleotides may also contain at least one nucleotide sequence change from the targeted sequence in the genome. The method includes modifying a genomic sequence within a cell utilizing an editing oligonucleotide without additional proteins or nucleic acids to assist in the editing process. The editing oligonucleotide may comprise backbone modifications that increase the nuclease stability of the oligonucleotide as compared to unmodified oligonucleotides or oligonucleotides having three phosphorothioates on each terminus.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 23, 2021
    Inventors: Tod M. WOOLF, Alexandre LEBEDEV, Richard I. HOGREFE
  • Publication number: 20210371452
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: August 2, 2021
    Publication date: December 2, 2021
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Publication number: 20210261597
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7 Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: November 6, 2020
    Publication date: August 26, 2021
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Patent number: 10913768
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: February 9, 2021
    Assignee: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Patent number: 10519189
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: December 31, 2019
    Assignee: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Patent number: 10494399
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: December 3, 2019
    Assignee: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Publication number: 20190270766
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: April 1, 2019
    Publication date: September 5, 2019
    Applicant: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Publication number: 20190144490
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: December 26, 2018
    Publication date: May 16, 2019
    Applicant: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Publication number: 20180273576
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: September 20, 2016
    Publication date: September 27, 2018
    Applicant: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Patent number: 7999098
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: August 16, 2011
    Assignee: Solulink Biosciences, Inc.
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Patent number: 7732628
    Abstract: Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: June 8, 2010
    Assignee: Solulink Incorporated
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Patent number: 7173125
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: February 6, 2007
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Patent number: 7102024
    Abstract: Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: September 5, 2006
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Publication number: 20040214199
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Application
    Filed: November 24, 2003
    Publication date: October 28, 2004
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Patent number: 6686461
    Abstract: Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: February 3, 2004
    Assignee: Solulink Bioscience, Inc.
    Inventors: David A. Schwartz, Richard I. Hogrefe
  • Patent number: 6320041
    Abstract: The present invention provides a variety of compositions that comprise an activated carboxylic ester moiety on one end of an alkyl tether and a nucleic acid binding moiety on the other end for use as crosslinking reagents in conjugation reactions of nucleotides with solid support matrixes, organic molecules, reporter groups or other biomolecules.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: November 20, 2001
    Assignee: Trilink Biotechnologies, Inc.
    Inventors: Richard I. Hogrefe, Morteza M. Vaghefi
  • Patent number: 5792615
    Abstract: Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: August 11, 1998
    Assignee: Genta, Incorporated
    Inventors: Lyle J. Arnold, Jr., Richard I. Hogrefe, Mark A. Reynolds, Timothy A. Riley, David A. Schwartz
  • Patent number: RE46171
    Abstract: Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: October 4, 2016
    Assignee: SOLULINK, INCORPORATED
    Inventors: David A. Schwartz, Richard I. Hogrefe