Patents by Inventor Richard Irving Sherwood

Richard Irving Sherwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR PREDICTING REPAIR OUTCOMES IN GENETIC ENGINEERING
    Publication number: 20220238182
    Abstract: The specification provides methods for introducing a desired genetic change in a nucleotide sequence using a double-strand break (DSB)-inducing genome editing system, the method comprising: identifying one or more available cut sites in a nucleotide sequence; analyzing the nucleotide sequence and available cut sites with a computational model to identify the optimal cut site for introducing the desired genetic change into the nucleotide sequence; and contacting the nucleotide sequence with a DSB-inducing genome editing system, thereby introducing the desired genetic change in the nucleotide sequence at the cut site.
    Type: Application
    Filed: December 15, 2018
    Publication date: July 28, 2022
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Max Walt Shen, Jonathan Yee-Ting Flsu, Mandana Arbab, David K. Gifford, David R. Liu, Richard Irving Sherwood
  • High-throughput CRISPR-based library screening
    Patent number: 11306308
    Abstract: Provided herein is an improved method for performing CRISPR/Cas based screening that is not dependent on viral cloning methods.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: April 19, 2022
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: David K. Gifford, Nisha Rajagopal, Richard Irving Sherwood
  • HIGH-THROUGHPUT CRISPR-BASED LIBRARY SCREENING
    Publication number: 20180327740
    Abstract: Provided herein is an improved method for performing CRISPR/Cas based screening that is not dependent on viral cloning methods.
    Type: Application
    Filed: November 11, 2016
    Publication date: November 15, 2018
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: David K. Gifford, Nisha Rajagopal, Richard Irving Sherwood
  • Isolation and characterization of muscle regenerating cells
    Patent number: 7749754
    Abstract: Populations enriched for myogenic progenitors are obtained by selection on the basis of expression of specific cell surface markers. The muscle progenitor cells are characterized as being CD45? and CD34+, and may further be characterized as lacking expression of Mac-1 (CD11b) and positive for expression of CXCR4 (CD184) and ?1-integrin (CD29).
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: July 6, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard Irving Sherwood, Amy Jo Wagers, Irving Weissman