Patents by Inventor Richard J. Bochis
Richard J. Bochis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5670504Abstract: A class of 2,6-diarylpyridazinones of general structural formula I have been identified that exhibit exhibit immunosuppressant activity with human T-lymphocytes, and are useful as an immunosuppressants.Type: GrantFiled: February 23, 1995Date of Patent: September 23, 1997Assignee: Merck & Co. Inc.Inventors: Richard J. Bochis, Andrew Kotliar, William H. Parsons, Kathleen Rupprecht
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Patent number: 5583130Abstract: There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. The compounds are prepared by substitution of an amino-lactam with a substituted amide function. Growth promoting compositions containing such bezno-fused lactams as the active ingredient thereof are also disclosed.Type: GrantFiled: September 25, 1992Date of Patent: December 10, 1996Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Michael H. Fisher, Robert J. Devita, William R. Schoen, Matthew J. Wyvratt
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Patent number: 5545735Abstract: There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.Type: GrantFiled: October 4, 1993Date of Patent: August 13, 1996Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Paul J. Hodges, William R. Schoen, Matthew J. Wyvratt, Jr.
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Patent number: 5283241Abstract: There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. The compounds are prepared by substitution of an amino-lactam with a substituted amide function. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.Type: GrantFiled: August 28, 1992Date of Patent: February 1, 1994Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Matthew J. Wyvratt, William R. Schoen
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Patent number: 5143918Abstract: Novel C-3" and C-4" halogen-substituted macrolides of FK-506 type structural Formula I: ##STR1## are described. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases (such as juvenile-onset diabetes melitus, multiple sclerosis and rheumatoid arthritis), infectious diseases and/or the prevention of rejection of foreign organ transplants, e.g. bone marrow and heart transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses such as: psoriasis, atopical dermatitiis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasulitides erythemas, cutaneous eosinophilias, Lupus erythematosus or Alopecia areata.Type: GrantFiled: September 12, 1991Date of Patent: September 1, 1992Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Matthew J. Wyvratt, Jr.
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Patent number: 5064835Abstract: Novel hydroxymacrolide derivatives of the general structural Formula I: ##STR1## have been prepared from (a) suitable precursor(s) by selective reduction of the ketone at C-2. These macrolide immunosuppressants are useful in a human host for the treatment of autoimmune diseases (such as juvenile-onset diabetes melitus, multiple sclerosis and rheumatoid arthritis), infectious diseases and/or the prevention of rejection of foreign organ transplants, e.g. bone marrow and heart transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses such as: psoriasis, atopical dermatitiis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eospinphilias, Lupus erythematosus or Alopecia areata.Type: GrantFiled: March 1, 1990Date of Patent: November 12, 1991Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Huyn O. Ok, Matthew J. Wyvratt
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Patent number: 4950673Abstract: Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.Type: GrantFiled: August 18, 1988Date of Patent: August 21, 1990Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Richard L. Tolman, Elbert Harris
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Patent number: 4816469Abstract: Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.Type: GrantFiled: November 6, 1987Date of Patent: March 28, 1989Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Richard L. Tolman, Elbert Harris
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Patent number: 4721791Abstract: Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.Type: GrantFiled: May 19, 1986Date of Patent: January 26, 1988Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Elbert Harris, Richard L. Tolman
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Patent number: 4622330Abstract: Novel 3-amino or substituted amino pyrazoles are disclosed as having antiprotozoal and antiparasitic activity in particular anticoccidial activity and are useful for controlling cecal and or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.Type: GrantFiled: June 19, 1984Date of Patent: November 11, 1986Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Richard A. Dybas, Edward F. Rogers
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Patent number: 4590201Abstract: Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.Type: GrantFiled: February 2, 1984Date of Patent: May 20, 1986Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, John C. Chabala, Michael H. Fisher
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Patent number: 4482545Abstract: There is disclosed the novel compound isoefrotomycin which is synthesized from efrotomycin as a Michael adduct by treatment with a mixture of polar and nonpolar solvents. Isoefrotomycin is an effective antimicrobial agent and growth promotant in animals.Type: GrantFiled: October 13, 1983Date of Patent: November 13, 1984Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Ray S. Dewey
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Patent number: 4289784Abstract: Novel substituted pyromellitic diimides are disclosed wherein the compounds are assymetrically substituted with a variety of substituent groups. Processes for the preparation of such compounds are also disclosed. The novel assymetrically substituted pyromellitic diimides are useful for administration to ruminant animals to increase feed efficiency, shift volatile fatty acid production in the ruminants from acetate with an increase in the more energetically efficient propionate and butyrate and to suppress methane formation in the rumen. Composition and methods of treatment utilizing said compounds as the active ingredient thereof are also disclosed.Type: GrantFiled: April 22, 1980Date of Patent: September 15, 1981Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Michael H. Fisher, Bruce O. Linn
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Patent number: 4250174Abstract: Imidazo pyridines with a carbamate group in the 2-position and a phenylthio, or phenylsulfinyl group in the 6-position are disclosed which also are substituted at the 3-position. The 3-position substituents may be halogen, substituted aminomethyl, acyl, and the like. The compounds are active anthelmintic agents. Compositions and methods for the use of such compounds against helmintic infections are also disclosed.Type: GrantFiled: May 2, 1979Date of Patent: February 10, 1981Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Peter Kulsa, Richard L. Tolman
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Patent number: 4237300Abstract: Certain novel substituted imidazo [1,2-a] pyridines with a substituted amino group at the 2- or 3-position are active anthelmintic agents. The novel compounds are prepared from the appropriate substituted 2-aminopyridine precursor. Compositions which utilize said novel imidazo [1,2-a] pyridines as the active ingredient thereof for the treatment of helminthiasis are also disclosed.Type: GrantFiled: November 9, 1979Date of Patent: December 2, 1980Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Peter Kulsa
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Patent number: 4177274Abstract: Certain novel substituted imidazo [1,2-a] pyridines with a substituted amino group at the 2- or 3-position are active anthelmintic agents. The novel compounds are prepared from the appropriate substituted 2-aminopyridine precursor. Compositions which utilize said novel imidazo [1,2-a] pyridines as the active ingredient thereof for the treatment of helminthiasis are also disclosed.Type: GrantFiled: June 5, 1978Date of Patent: December 4, 1979Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Peter Kulsa
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Patent number: 4154835Abstract: Novel substituted imidazo [1,2-a] pyridine compounds are disclosed which have a high degree of anthelmintic activity. The compounds are substituted with a carbamate and a halogenated alkene group. Processes for the preparation of such compounds are also disclosed as well as compositions which use the described compounds as active ingredients for the treatment of helminthiasis.Type: GrantFiled: October 12, 1977Date of Patent: May 15, 1979Assignee: Merck & Co., Inc.Inventor: Richard J. Bochis
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Patent number: 4146642Abstract: Certain novel substituted imidazo [1,2-a] pyridines with a substituted amino group at the 2- or 3- position and a heterocyclic moiety on the pyrido portion of the molecule are active anthelmintic agents. The heterocyclic moiety is connected to the imidazo [1,2-a] pyridine molecule through an oxygen, sulfur, sulfinyl or sulfone. The novel compounds are prepared from the appropriately substituted 2-amino pyridine precursor. Compositions which utilize said novel imidazo [1,2-a] pyridines as the active ingredient thereof for the treatment of helminthiasis are also disclosed.Type: GrantFiled: May 30, 1978Date of Patent: March 27, 1979Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Richard L. Tolman
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Patent number: 4105767Abstract: Certain novel substituted imidazo [1,2-a] pyridines with a substituted amino group at the 2- or 3- position and a heterocyclic moiety on the pyrido portion of the molecule are active anthelmintic agents. The heterocyclic moiety is connected to the imidazo [1,2-a] pyridine molecule through an oxygen, sulfur, sulfinyl or sulfone. The novel compounds are prepared from the appropriately substituted 2-amino pyridine precursor. Compositions which utilize said novel imidazo [1,2-a] pyridines as the active ingredient thereof for the treatment of helminthiasis are also disclosed.Type: GrantFiled: March 28, 1977Date of Patent: August 8, 1978Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Richard L. Tolman
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Patent number: 4096264Abstract: Certain novel substituted imidazo [1,2-a] pyridines with a substituted amino group at the 2- or 3-position are active anthelmintic agents. The novel compounds are prepared from the appropriate substituted 2-aminopyridine precursor. Compositions which utilize said novel imidazo [1,2-a] pyridines as the active ingredient thereof for the treatment of helminthiasis are also disclosed.Type: GrantFiled: August 26, 1976Date of Patent: June 20, 1978Assignee: Merck & Co., Inc.Inventors: Richard J. Bochis, Peter Kulsa