Abstract: Described herein are elongate applicator tools adapted to be inserted into an anatomical structure of a body to deliver electric treatment, for example, high voltage, sub-microsecond electrical energy, to a target tissue. These applicator tools may be configured for insertion into a blood vessel, an otolaryngological structure (such as an ear, nose, or throat, including anatomical structures, such as a turbinate, tonsils, tongue, soft palate, parotid glands, esophageal glands), a gastrointestinal tract (e.g., stomach, small intestine, large intestine, duodenum, colon, etc., including the esophagus), structures of the female reproductive system (e.g., fallopian tubes, uterus), and/or a respiratory tract (e.g., trachea, pharynx, larynx, and bronchi). Also disclosed herein are systems including these tools and methods of their operation.

Abstract: Described herein are electrical applicator devices having a funnel-shaped portion with one or more electrodes on a distal-facing end region of the funnel shape. These devices may be deployable by inverting a braided or woven body back into itself to form the funnel. These devices may be used to perform a medical procedure, such as an ablation procedure.

Abstract: An adaptive control method for controlling EP pulse parameters during electroporation (EP) of cells or tissue using an EP system includes providing a system for adaptive control to optimize EP pulse parameters including EP pulse parameters, applying voltage and current excitation signals to the cells, obtaining data from the current and voltage measurements, and processing the data to separate the desirable data from the undesirable data, extracting relevant features from the desirable data, applying at least a portion of the relevant features to a trained diagnostic model, estimating EP pulsing parameters based on an outcome of the applied relevant features, where the initialized EP pulsing parameters are based on the trained model and the relevant features, to optimize the EP pulsing parameters, and applying, by the generator, a first EP pulse based on the first pulsing parameters.

Abstract: An adaptive control method for controlling EP pulse parameters during electroporation (EP) of cells or tissue using an EP system includes providing a system for adaptive control to optimize EP pulse parameters including EP pulse parameters, applying voltage and current excitation signals to the cells, obtaining data from the current and voltage measurements, and processing the data to separate the desirable data from the undesirable data, extracting relevant features from the desirable data, applying at least a portion of the relevant features to a trained diagnostic model, estimating EP pulsing parameters based on an outcome of the applied relevant features, where the initialized EP pulsing parameters are based on the trained model and the relevant features, to optimize the EP pulsing parameters, and applying, by the generator, a first EP pulse based on the first pulsing parameters.

Abstract: An adaptive control method for controlling EP pulse parameters during electroporation (EP) of cells or tissue using an EP system includes providing a system for adaptive control to optimize EP pulse parameters including EP pulse parameters, applying voltage and current excitation signals to the cells, obtaining data from the current and voltage measurements, and processing the data to separate the desirable data from the undesirable data, extracting relevant features from the desirable data, applying at least a portion of the relevant features to a trained diagnostic model, estimating EP pulsing parameters based on an outcome of the applied relevant features, where the initialized EP pulsing parameters are based on the trained model and the relevant features, to optimize the EP pulsing parameters, and applying, by the generator, a first EP pulse based on the first pulsing parameters.

Abstract: Systems and methods are disclosed for monitoring corrosion of a structure by using the structure itself as part of the electrochemical measurement. According to some implementations, linear polarization resistance (LPR) sensor devices for direct monitoring of corrosion on a structure are presented. According to certain innovations herein, a sensor device may include three electrodes, such as a counter electrode, a reference electrode, and a working electrode comprised of the structure being monitored. In further embodiments, each electrode may be configured on a polymer flexible substrate cable such as polyimide, with each electrode fabricated from a noble metal, for example, gold-plated copper, or metal systems in which the exterior surface will not oxidize from environmental exposure.

Abstract: Cell or tissue permeability to electrical signals can be used to determine the depth of anesthesia of a patient. A method and device is presented to measure, record and control the effects of anesthesia or analgesics on humans and/or animals. Based on impedance values of tissues measured at single, multiple, or a domain of frequencies, the system detects tissue permeability alterations as determined by electromagnetic, impedance, and/or dielectric spectroscopy. The system measures the permeability of tissues to electrical signals and correlates these values to the depth of anesthesia or sedation level of a certain tissue or individual. This method and device can be used to measure the effects of anesthesia or analgesic for either local or systemic administration.

Abstract: A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a biological structure comprising a cell and applying a substantially continuous low-level electric field, in the form of non-thermal plasma (ionized gas) generated by a direct current voltage applied to an electrode, to the molecule and biological structure. The field is applied for a duration sufficient to effect a change in porosity the cell of the biological structure sufficient to facilitate an entry of a desired molecule into an interior thereof.

Abstract: A device and method to cause hair loss or prevent or inhibit hair growth. The invention uses plasma (ionized gas) that is generated by flowing gas in close proximity to an electrode that has a high potential applied to it. The result is a stream of charged gas particles that are directed to the skin that contains hair. The flowing stream of gas is held above the surface of the skin. Additionally, a grounded conductive material is affixed to the skin to dissipate any charge buildup on the skin and focus the plasma.

Abstract: A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a biological structure comprising a cell and applying a substantially continuous low-level electric field, in the form of non-thermal plasma (ionized gas) generated by a direct current voltage applied to an electrode, to the molecule and biological structure. The field is applied for a duration sufficient to effect a change in porosity the cell of the biological structure sufficient to facilitate an entry of a desired molecule into an interior thereof.