Patents by Inventor Richard J. Cristiano

Richard J. Cristiano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced expression of transgenes
    Patent number: 6989375
    Abstract: The present invention provides for improved methods of gene transfer, both in vitro and in vivo. By treating neoplastic cells with a DNA-damaging agent prior to transduction with a transgene, the expression of the transgene is improved up to about 3-fold over the expression seen in the absence of the DNA-damaging agent treatment. This effect is not dependent on the tumor cell type, the method of DNA transduction or type of DNA-damaging agent. The effect is most dramatic when the transduction is performed about 1-3 days following treatment with the DNA-damaging agent.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: January 24, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard J. Cristiano, Dao Nguyen
  • PEI: DNA vector formulations for in vitro and in vivo gene delivery
    Patent number: 6846809
    Abstract: The present invention relates generally to the fields of nucleic acid transfection. More particularly, it concerns novel polycation:nucleic acid compositions, methods of preparation of such compositions and methods of transfecting cells with such compositions.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: January 25, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard J. Cristiano, Motoyuki Yamashita
  • PEI: DNA vector formulations for in vitro and in vivo gene delivery
    Publication number: 20020151060
    Abstract: The present invention relates generally to the fields of nucleic acid transfection. More particularly, it concerns novel polycation:nucleic acid compositions, methods of preparation of such compositions and methods of transfecting cells with such compositions.
    Type: Application
    Filed: September 25, 2001
    Publication date: October 17, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Richard J. Cristiano, Motoyuki Yamashita
  • Enhanced expression of transgenes
    Publication number: 20020123477
    Abstract: The present invention provides for improved methods of gene transfer, both in vitro and in vivo. By treating neoplastic cells with a DNA-damaging agent prior to transduction with a transgene, the expression of the transgene is improved up to about 3-fold over the expression seen in the absence of the DNA-damaging agent treatment. This effect is not dependent on the tumor cell type, the method of DNA transduction or type of DNA-damaging agent. The effect is most dramatic when the transduction is performed about 1-3 days following treatment with the DNA-damaging agent.
    Type: Application
    Filed: August 3, 2001
    Publication date: September 5, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Richard J. Cristiano, Dao Nguyen
  • Enhanced expression of transgenes
    Patent number: 6271207
    Abstract: The present invention provides for improved methods of gene transfer, both in vitro and in vivo. By treating neoplastic cells with a DNA-damaging agent prior to transduction with a transgene, the expression of the transgene is improved up to about 3-fold over the expression seen in the absence of the DNA-damaging agent treatment. This effect is not dependent on the tumor cell type, the method of DNA transduction or type of DNA-damaging agent. The effect is most dramatic when the transduction is performed about 1-3 days following treatment with the DNA-damaging agent.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: August 7, 2001
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard J. Cristiano, Dao Nguyen
  • Nucleic acid transporter systems
    Patent number: 6177554
    Abstract: Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 23, 2001
    Assignee: Baylor College of Medicine
    Inventors: Savio L. C. Woo, Louis C. Smith, Richard J. Cristiano, Stephen Gottchalk, Jim Sparrow
  • Nucleic acid transporter systems and methods of use
    Patent number: 6150168
    Abstract: Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 21, 2000
    Assignee: Baylor College of Medicine
    Inventors: Savio L. C. Woo, Louis C. Smith, Richard J. Cristiano, Stephen Gottchalk, Jim Sparrow
  • Nucleic acid transporter systems and methods of use
    Patent number: 6033884
    Abstract: Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: March 7, 2000
    Assignee: Baylor College of Medicine
    Inventors: Savio L. C. Woo, Louis C. Smith, Richard J. Cristiano, Stephen Gottchalk, Jim Sparrow
  • Nucleic acid transporter system and methods of use
    Patent number: 5994109
    Abstract: Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.
    Type: Grant
    Filed: June 3, 1995
    Date of Patent: November 30, 1999
    Assignee: Baylor College of Medicine
    Inventors: Savio L. C. Woo, Louis C. Smith, Richard J. Cristiano, Stephen Gottchalk, Jim Sparrow