Abstract: A method for making the compound of Formula I: is set forth using alkylation, amidation, chlorination and phosphate installation procedures.

Abstract: The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.

Abstract: A method for making the compound of Formula I: is set forth using alkylation, amidation, chlorination and phosphate installation procedures.

Abstract: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.

Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.

Abstract: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.

Abstract: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.

Abstract: The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.

Abstract: The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.

Abstract: The present disclosure relates to methods for generating libraries of polynucleotide variants comprising defined nucleotide differences relative to a reference polynucleotide.

Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.

Abstract: A system and method are disclosed for providing an improved rack arm system wherein insulating material is utilized to guard against stray voltage. The system and method entail providing insulated rack arm systems for installation in new locations as well as a snap-on insulating piece for utilization with existing rack arm systems.

Abstract: A folder operable to cut a printed web received from a printing press. The folder includes a cutting section having cutting cylinders that cut the web into individual printed products, and a cutting motor that is operable to drive the cutting cylinders. A delivery assembly of the folder includes delivery belts that are operable to guide the individual printed products through the folder, and at least one delivery motor is operable to drive the delivery belts. The folder also includes a diverting assembly that diverts individual printed products to one of a plurality of collation paths, and a diverting motor that is operable to drive the diverting assembly. The cutting motor, the delivery motor, and the diverting motor are operable independently of one another.

Abstract: This invention provides a method and a mold for improving the release of a molded ophthalmic device from a mold. The method comprises the steps of: providing a first mold half and second mold half each having opposing top surfaces at least one of which has been hollowed out to define a cavity for forming said ophthalmic device and at least said first mold half further defining a boundary for a release element, said boundary is part of said cavity, said release element comprising a ramped surface, said cavity having a corresponding ramped surface, and said release element having its widest part near the top surface of said at least said first mold half that defines said release element therein. The mold of this invention has a hollowed-out portion as part of the cavity to provide a release element to the molded ophthalmic device.

Abstract: This invention provides a method and a mold for improving the release of a molded ophthalmic device from a mold. The method comprises the steps of: providing a first mold half and second mold half each having opposing top surfaces at least one of which has been hollowed out to define a cavity for forming said ophthalmic device and at least said first mold half further defining a boundary for a release element, said boundary is part of said cavity, said release element comprising a ramped surface, said cavity having a corresponding ramped surface, and said release element having its widest part near the top surface of said at least said first mold half that defines said release element therein. The mold of this invention has a hollowed-out portion as part of the cavity to provide a release element to the molded ophthalmic device.

Abstract: A delivery apparatus for sorting a single stream of signatures into two or more streams, the apparatus includes two counter-rotating bucket assemblies. Each bucket assembly includes a plurality of buckets spaced from one another along a common axis. The respective common axis of each bucket assembly is disposed parallel to the common axis of the other. Each of the buckets of one of the bucket assemblies is disposed adjacent to and in a respective common plane with a respective one of the buckets of the other of the bucket assemblies. Further, each of the buckets includes a plurality of blades, the tips of the blades of each bucket defining a circumference. A respective circumference of one bucket overlaps the circumference of the other bucket disposed in the common plane. Two neighboring blades have respective surfaces defining a slot therebetween.

Abstract: A delivery apparatus for sorting a single stream of signatures into two or more streams, the apparatus includes two counter-rotating bucket assemblies. Each bucket assembly includes a plurality of buckets spaced from one another along a common axis. The respective common axis of each bucket assembly is disposed parallel to the common axis of the other. Each of the buckets of one of the bucket assemblies is disposed adjacent to and in a respective common plane with a respective one of the buckets of the other of the bucket assemblies. Further, each of the buckets includes a plurality of blades, the tips of the blades of each bucket defining a circumference. A respective circumference of one bucket overlaps the circumference of the other bucket disposed in the common plane. Two neighboring blades have respective surfaces defining a slot therebetween.

Abstract: A delivery apparatus for sorting a single stream of signatures into two or more streams, the apparatus includes two counter-rotating bucket assemblies. Each bucket assembly includes a plurality of buckets spaced from one another along a common axis. The respective common axis of each bucket assembly is disposed parallel to the common axis of the other. Each of the buckets of one of the bucket assemblies is disposed adjacent to and in a respective common plane with a respective one of the buckets of the other of the bucket assemblies. Further, each of the buckets includes a plurality of blades, the tips of the blades of each bucket defining an outer circle. A respective outer circle of one bucket overlaps the outer circle of the opposing bucket disposed in the common plane. Two neighboring blades have respective surfaces defining a slot therebetween.

Abstract: An adjustable signature stripping mechanism for stripping signatures from a rotating bucket assembly in a folder of a printing press. The mechanism includes a stripper shaft having a mounting portion and a pivot axis and a plurality of strippers mounted on the stripper shaft for stripping signatures from the bucket assembly and wherein the strippers are non-rotatable relative to the stripper shaft and slidable positionable along the stripper shaft.

Abstract: A computer-based system and method which incorporates long-range weather forecasts in a predictive model which quantifies historical weather impact relationships between datasets, and uses the long-range weather forecasts to predict future weather impact on managerial plans. The predictive model can use multiple regression or a neural network. In a retail application, the computer-based system and method has a weather impact predictive model based on correlations of historical weather and point-of-sale store transactions data. The weather impact model is coupled with long-range weather forecasts to adjust managerial plans for buying, distribution, financial budgeting, promotional and advertising applications. A graphical user interface provides easy assimilation of analysis for specific managerial planning applications.