Patents by Inventor Richard J. Hamilton

Richard J. Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190270736
    Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
    Type: Application
    Filed: May 14, 2019
    Publication date: September 5, 2019
    Inventors: Maria Emilia DI FRANCESCO, Philip JONES, Timothy HEFFERNAN, Matthew M. HAMILTON, Zhijun KANG, Michael J. SOTH, Jason P. BURKE, Kang LE, Christopher Lawrence CARROLL, Wylie S. PALMER, Richard LEWIS, Timothy MCAFOOS, Barbara CZAKO, Gang LIU, Jay THEROFF, Zachary HERRERA, Anne YAU
  • Patent number: 10344025
    Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: July 9, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Maria Emilia Di Francesco, Philip Jones, Timothy Heffernan, Matthew M. Hamilton, Zhijun Kang, Michael J. Soth, Jason P. Burke, Kang Le, Christopher Lawrence Carroll, Wylie S. Palmer, Richard Lewis, Timothy McAfoos, Barbara Czako, Gang Liu, Jay Theroff, Zachary Herrera, Anne Yau
  • Patent number: 8388618
    Abstract: The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-thermal plasma is generated, the second electrode being human tissue, blood, etc. To reduce the likelihood of an arc being generated, potentially causing tissue damage or pain, the first electrode is partially encapsulated by a dielectric. The non-thermal plasma is applied to the area of bleeding for treatment.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: March 5, 2013
    Assignees: Drexel University, Philadelphia Health & Education Corporation
    Inventors: Gregory Fridman, Alexander Fridman, Alexander F. Gutsol, Gennady Friedman, David Staack, Richard J. Hamilton
  • Patent number: 6398128
    Abstract: A spraying system having a plurality of spray nozzle assemblies mounted on a common liquid supply header. The spray nozzle assemblies each include a nozzle body fixed to the header and a spray tip secured to the body as an incident to rotation of the spray tip relative to the body. Each spray tip has an elongated discharge orifice adapted for emitting a flat spray pattern and is formed with radial gripping wings in aligned relation to the elongated discharge orifice which enable the user to know the orientation of the discharge orifice, and hence the orientation of the flat discharging spray pattern, prior to start up of a spray operation.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: June 4, 2002
    Assignee: Spraying Systems Co.
    Inventors: Richard J. Hamilton, Gerald P. Ferrazza
  • Patent number: 6182908
    Abstract: A solenoid operated liquid spray device which includes a flow control module disposed within the solenoid coil of the device for controlling the direction of pressurized through the spray device. The flow control module includes separate inlet and outlet portions which can be easily disassembled for on line service without necessity for disconnecting fluid supply and electric power lines. The outlet portion is secured to the inlet portion by an adjustable retainer which is selectively positionable for adjusting the operating stroke of the valve plunger without the necessity for damaging relative rotational movement between the valve plunger needle and valve seat. The module portions further define a first flow passageway communicating between a liquid inlet and discharge nozzle and a second or return passageway communicating with a heated liquid supply for enabling liquid in the spray device to be maintained at an optimum heated temperature when a spraying operation is interrupted.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: February 6, 2001
    Assignee: Spraying Systems Co.
    Inventor: Richard J. Hamilton
  • Patent number: 5727739
    Abstract: A quick disconnect nozzle comprising a nozzle body, a spray tip, and an annular sealing member interposed therebetween. The tip is adapted to be inserted axially into the body and then rotated. When the tip is rotated, camming lugs on the tip and body coact to draw the tip axially toward the body and compress the sealing member. Detents in the form of flexible curved ribs are carried by the tip and resiliently pop into curved pockets in the body to releasably hold the tip in its installed position. The sealing member is an O-ring which is carried by the tip and which is removable from the body as a unit with the tip. An inner seal is provided between mutually converging tapered walls of the nozzle tip and nozzle body adjacent the inner end portion of the nozzle tip.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: March 17, 1998
    Assignee: Spraying Systems Co.
    Inventor: Richard J. Hamilton
  • Patent number: 5294057
    Abstract: A solenoid operated liquid spray gun for use in directing small volume, air atomized liquid at short operating intervals. The spray gun includes a housing having pressurized liquid and air inlets, a solenoid coil contained within the housing, and a fluid control module disposed within the solenoid coil for controlling the flow of liquid from the liquid inlet through a discharge nozzle. The solenoid coil and module further define an annular air passage within the housing for communicating pressurized air from the air inlet to the nozzle for facilitating atomization and direction of the liquid discharging from the gun.
    Type: Grant
    Filed: April 21, 1992
    Date of Patent: March 15, 1994
    Assignee: Spraying Systems Co.
    Inventor: Richard J. Hamilton
  • Patent number: 5190224
    Abstract: A quick disconnect nozzle assembly comprising a nozzle body, a spray tip, and an annular sealing member interposed therebetween. The nozzle body and spray tip have inclined seal engaging surfaces that compress the annular sealing member at three distinct points for exerting both axial and radial pressures thereon, and the body and spray tip have cams and separate radial detents for smoothly drawing the tip and body together into sealing engagement with the annular sealing member in repsonse to tip rotation and without the necessity for overcompressing the sealing member. A secondary, external sealing member is provided, which together with the internal sealing member, seal the cams and detents in an internal chamber area isolated from the liquid sprayed by the nozzle.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: March 2, 1993
    Assignee: Spraying Systems Co.
    Inventor: Richard J. Hamilton
  • Patent number: D439636
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: March 27, 2001
    Assignee: Spraying Systems Co.
    Inventor: Richard J. Hamilton