Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A personal protective respirator comprising a facepiece housing configured to cover the nose and mouth and conform to a face of an intended wearer along a perimeter of the facepiece housing and at least two straps, wherein the facepiece housing and the straps consist of a knitted material and the facepiece housing conforms to the face of the intended wearer such that sufficient fit is achieved to attain a fit factor of at least 100 on the intended wearer according to OSHA fit testing procedures. Also, a personal protective respirator comprising a face portion configured to cover a nose and mouth of an intended wearer and to conform to a face of the intended wearer and at least four straps, wherein the mask meets NIOSH requirements for N95 respirator performance and maintains this level of performance after being washed. Finally, a method for making the noted personal protective respirators.

Abstract: The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-thermal plasma is generated, the second electrode being human tissue, blood, etc. To reduce the likelihood of an arc being generated, potentially causing tissue damage or pain, the first electrode is partially encapsulated by a dielectric. The non-thermal plasma is applied to the area of bleeding for treatment.

Abstract: A spraying system having a plurality of spray nozzle assemblies mounted on a common liquid supply header. The spray nozzle assemblies each include a nozzle body fixed to the header and a spray tip secured to the body as an incident to rotation of the spray tip relative to the body. Each spray tip has an elongated discharge orifice adapted for emitting a flat spray pattern and is formed with radial gripping wings in aligned relation to the elongated discharge orifice which enable the user to know the orientation of the discharge orifice, and hence the orientation of the flat discharging spray pattern, prior to start up of a spray operation.

Abstract: A solenoid operated liquid spray device which includes a flow control module disposed within the solenoid coil of the device for controlling the direction of pressurized through the spray device. The flow control module includes separate inlet and outlet portions which can be easily disassembled for on line service without necessity for disconnecting fluid supply and electric power lines. The outlet portion is secured to the inlet portion by an adjustable retainer which is selectively positionable for adjusting the operating stroke of the valve plunger without the necessity for damaging relative rotational movement between the valve plunger needle and valve seat. The module portions further define a first flow passageway communicating between a liquid inlet and discharge nozzle and a second or return passageway communicating with a heated liquid supply for enabling liquid in the spray device to be maintained at an optimum heated temperature when a spraying operation is interrupted.

Abstract: A quick disconnect nozzle comprising a nozzle body, a spray tip, and an annular sealing member interposed therebetween. The tip is adapted to be inserted axially into the body and then rotated. When the tip is rotated, camming lugs on the tip and body coact to draw the tip axially toward the body and compress the sealing member. Detents in the form of flexible curved ribs are carried by the tip and resiliently pop into curved pockets in the body to releasably hold the tip in its installed position. The sealing member is an O-ring which is carried by the tip and which is removable from the body as a unit with the tip. An inner seal is provided between mutually converging tapered walls of the nozzle tip and nozzle body adjacent the inner end portion of the nozzle tip.

Abstract: A solenoid operated liquid spray gun for use in directing small volume, air atomized liquid at short operating intervals. The spray gun includes a housing having pressurized liquid and air inlets, a solenoid coil contained within the housing, and a fluid control module disposed within the solenoid coil for controlling the flow of liquid from the liquid inlet through a discharge nozzle. The solenoid coil and module further define an annular air passage within the housing for communicating pressurized air from the air inlet to the nozzle for facilitating atomization and direction of the liquid discharging from the gun.

Abstract: A quick disconnect nozzle assembly comprising a nozzle body, a spray tip, and an annular sealing member interposed therebetween. The nozzle body and spray tip have inclined seal engaging surfaces that compress the annular sealing member at three distinct points for exerting both axial and radial pressures thereon, and the body and spray tip have cams and separate radial detents for smoothly drawing the tip and body together into sealing engagement with the annular sealing member in repsonse to tip rotation and without the necessity for overcompressing the sealing member. A secondary, external sealing member is provided, which together with the internal sealing member, seal the cams and detents in an internal chamber area isolated from the liquid sprayed by the nozzle.