Patents by Inventor Richard J. Holl
Richard J. Holl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230149635Abstract: The present invention provides an applicator for insertion of drug delivery device for subdermal administration of contraceptive or hormone replacement therapy comprising a housing, a needle, a pushrod, a needle guiding means, a protective cover and an actuator. The applicator comprises a mechanism wherein needle is crimped such that it help to secure the implant inside the needle. Further, the invention provides a mechanism wherein implant is loaded into the applicator through a slot present in the needle at an angle perpendicular to the longitudinal axis of the needle.Type: ApplicationFiled: November 9, 2022Publication date: May 18, 2023Inventors: Richard J. Holl, Tomas Matusaitis
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Patent number: 11406635Abstract: Solid pharmaceutical dosage forms comprising (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate (telotristat) are disclosed, as well as methods of making them and compositions useful in their manufacture.Type: GrantFiled: November 19, 2019Date of Patent: August 9, 2022Assignee: TerSera Therapeutics LLCInventors: Jinling Chen, Matthew S. Deaver, Richard J. Holl, Kalyan Nuguru
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Publication number: 20210228477Abstract: A kit including topical pharmaceutical composition of corticosteroid(s) and metered-dose dispenser with an actuator which delivers precise amount of corticosteroid(s) per actuation for the treatment of various skin disorders is disclosed. Also disclosed is a process for preparation of such compositions.Type: ApplicationFiled: January 6, 2021Publication date: July 29, 2021Inventors: Matthew William Davis, Richard J. Holl, Avinash Nangia, Vineeth Raghavan, Amol Subhash Mandhare, Mukesh Kumar
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Publication number: 20210008068Abstract: Solid pharmaceutical dosage forms comprising (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate (telotristat) are disclosed, as well as methods of making them and compositions useful in their manufacture.Type: ApplicationFiled: November 19, 2019Publication date: January 14, 2021Inventors: Jinling CHEN, Matthew S. DEAVER, Richard J. HOLL, Kalyan NUGURU
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Publication number: 20190224112Abstract: A kit including topical pharmaceutical composition of corticosteroid(s) and metered-dose dispenser with an actuator which delivers precise amount of corticosteroid(s) per actuation for the treatment of various skin disorders is disclosed. Also disclosed is a process for preparation of such compositions.Type: ApplicationFiled: January 25, 2018Publication date: July 25, 2019Inventors: Matthew William Davis, Richard J. Holl, Avinash Nangia, Vineeth Raghavan, Amol Subhash Mandhare, Mukesh Kumar
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Publication number: 20190000843Abstract: Solid pharmaceutical dosage forms comprising (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate (telotristat) are disclosed, as well as methods of making them and compositions useful in their manufacture.Type: ApplicationFiled: June 5, 2017Publication date: January 3, 2019Inventors: Jinling CHEN, Matthew S. DEAVER, Richard J. HOLL, Kalyan NUGURU
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Publication number: 20150157632Abstract: Solid pharmaceutical dosage forms comprising (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4- yl)phenyl)propanoate (telotristat) are disclosed, as well as methods of making them and compositions useful in their manufacture.Type: ApplicationFiled: February 11, 2015Publication date: June 11, 2015Inventors: Jinling CHEN, Matthew S. DEAVER, Richard J. HOLL, Kalyan NUGURU
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Publication number: 20130236524Abstract: Implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants are provided. In particular, subcutaneous drug delivery systems having a biocompatible thermoplastic elastomeric polymer matrix, a therapeutic agent embedded homogeneously in said matrix, and a biocompatible drug impermeable cross-linked silicone polymer coating said matrix and methods of making the same are provided.Type: ApplicationFiled: September 7, 2012Publication date: September 12, 2013Applicant: AXXIA PHARMACEUTICALS, LLCInventors: Richard J. HOLL, Katherine HARTMAN, Stuart A. Grossman, Wayne C. Pollock
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Publication number: 20130172376Abstract: Solid pharmaceutical dosage forms comprising (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate (telotristat) are disclosed, as well as methods of making them and compositions useful in their manufacture.Type: ApplicationFiled: October 16, 2012Publication date: July 4, 2013Inventors: Jinling CHEN, Matthew S. DEAVER, Richard J. HOLL, Kalyan NUGURU
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Patent number: 8263108Abstract: A coaxial implant has been developed using entirely biodegradable polymeric materials. As referred to herein, a coaxial implant is a device having a core containing drug, surrounded by a semi-permeable membrane that controls the rate of release of material from the core. The device is formed by extrusion, using a pre-milling and extruding step to maximize uniformity of drug dispersion within the polymeric material. In one embodiment, the polymer is processed to yield a semi-crystalline polymer, rather than an amorphous polymer. The core containing the drug and the polymer membrane(s) can be the same or different polymer. The polymer can be the same or different composition (i.e., both polycaprolactone, or both poly(lactide-co-glycolide) of different monomer ratios, or polycaprolactone outside of a core of poly(lactide)), of the same or different molecular weights, and of the same or different chemical structure (i.e., crystalline, semi-crystalline or amorphous).Type: GrantFiled: June 21, 2002Date of Patent: September 11, 2012Assignee: Durect CorporationInventors: John W. Gibson, Arthur J. Tipton, Richard J. Holl, Stacey Meador
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Publication number: 20110021583Abstract: The invention provides a transmucosal pharmaceutical composition comprising an active compound, a bile salt and an osmolality adjusting ingredient, wherein the osmolality adjusting ingredient generates a localized hyperosmotic environment and maintains an osmolality level for a period of time sufficient to produce hypertonicity-facilitated transmucosal transport of said active compound across the mucosal tissue. The invention also provides a solid transmucosal dosage form containing the composition, as well as a method of treatment comprising administering the same. In one embodiment, the active compound is a triptan compound, e.g., sumatriptan and zolmitriptan.Type: ApplicationFiled: August 23, 2010Publication date: January 27, 2011Applicant: CEPHALON, INC.Inventors: Richard J. Holl, Matthew Lentz
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Publication number: 20100080829Abstract: The present invention relates to a new lyophilized pharmaceutical composition capable of adhering to oral mucosal tissue for an extended period of time for delivering active pharmaceutical ingredient through the oral mucosal tissue using transmucosal absorption.Type: ApplicationFiled: October 1, 2009Publication date: April 1, 2010Applicants: CEPHALON FRANCE, CEPHALON, INC.Inventors: Claire Dulieu, Steve Durfee, Richard J. Holl, Tam Nguyen
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Publication number: 20030007992Abstract: A coaxial implant has been developed using entirely biodegradable polymeric materials. As referred to herein, a coaxial implant is a device having a core containing drug, surrounded by a semi-permeable membrane that controls the rate of release of material from the core. The device is formed by extrusion, using a pre-milling and extruding step to maximize uniformity of drug dispersion within the polymeric material. In one embodiment, the polymer is processed to yield a semi-crystalline polymer, rather than an amorphous polymer. The core containing the drug and the polymer membrane(s) can be the same or different polymer. The polymer can be the same or different composition (i.e., both polycaprolactone, or both poly(lactide-co-glycolide) of different monomer ratios, or polycaprolactone outside of a core of poly(lactide)), of the same or different molecular weights, and of the same or different chemical structure (i.e., crystalline, semi-crystalline or amorphous).Type: ApplicationFiled: June 21, 2002Publication date: January 9, 2003Applicant: Southern BioSystems, Inc.Inventors: John W. Gibson, Arthur J. Tipton, Richard J. Holl, Stacey Meador
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Publication number: 20020142093Abstract: Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, and a second solvent that is totally or partially immiscible with the first solvent; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0.1% and 25% by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step.Type: ApplicationFiled: November 29, 2000Publication date: October 3, 2002Applicant: Southern BioSystems, Inc.Inventors: John W. Gibson, Richard J. Holl, Arthur J. Tipton
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Patent number: 6440493Abstract: Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, and a second solvent that is totally or partially immiscible with the first solvent; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0.1% and 25% by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step.Type: GrantFiled: November 29, 2000Date of Patent: August 27, 2002Assignee: Southern Biosystems, Inc.Inventors: John W. Gibson, Richard J. Holl, Arthur J. Tipton
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Patent number: 6291013Abstract: Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the continuous phase solvent has solubility in the extraction phase of between about 0.1% and 25% by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step.Type: GrantFiled: May 3, 1999Date of Patent: September 18, 2001Assignee: Southern BioSystems, Inc.Inventors: John W. Gibson, Richard J. Holl, Arthur J. Tipton
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Patent number: 5866151Abstract: A composition, comprising an agent, a carrier admixed with the agent to form a mixture, and a film-forming polymer coating around the mixture which is insoluble in a selected solvent. A biocidal composition, comprising a biocide, such as an aldehyde, a carrier admixed with the aldehyde to form a mixture, and a film-forming polymer coating around the mixture which is insoluble in a selected solvent. The composition of the invention further comprising an acidifying agent admixed with the aldehyde. The composition of the invention and an activator. An article of manufacture, comprising the composition of the invention contained inside a fluid-permeable mesh bag. A method of making a biocidal composition, comprising admixing a carrier with an aldehyde to form a mixture, and coating the mixture with a film-forming polymer coating which is insoluble in a selected solvent.Type: GrantFiled: April 10, 1996Date of Patent: February 2, 1999Assignee: Southern Research InstituteInventors: Richard J. Holl, David W. Mason, Alan H. Dean
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Patent number: 5747058Abstract: A composition for the controlled release of substances is provided that includes: (i) a non-polymeric, non-water soluble liquid carrier material (HVLCM) of viscosity of at least 5,000 cP at 37.degree. C. that does not crystallize neat under ambient or physiological conditions; and (ii) a substance to be delivered.Type: GrantFiled: June 7, 1995Date of Patent: May 5, 1998Assignee: Southern Biosystems, Inc.Inventors: Arthur J. Tipton, Richard J. Holl
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Patent number: 5554650Abstract: An antiphlogistic, analgesic, antipyretic parenteral preparation is disclosed comprising diclofenac, its salt, or both, a surfactant, cosurfactant, water, having a pH of 3-10, and optionally comprising an oily component, that can exhibit sustained therapeutic levels of diclofenac in plasma.Type: GrantFiled: July 28, 1994Date of Patent: September 10, 1996Assignee: Southern Research InstituteInventors: Richard J. Holl, Thomas R. Tice, Laura L. Williams
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Patent number: 4124061Abstract: A thermal storage unit comprising a bed of particulate solid material, a liquid situated in heat-exchanging relation with said bed and cooperating with said bed to define a liquid-solid system containing a thermocline, and means for introducing liquid into and extracting liquid from said liquid-solid system.Type: GrantFiled: November 1, 1976Date of Patent: November 7, 1978Assignee: Rockwell International CorporationInventors: Rex C. Mitchell, Joseph Friedman, Richard J. Holl, Charles R. Easton