Patents by Inventor Richard J. Kirschner

Richard J. Kirschner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression vector containing PL6M promoter and TAT32 ribosome binding site and host cells transformed therewith
    Patent number: 5759852
    Abstract: Disclosed are expression vectors useful as vectors in recombinant methods to facilitate expression of exogenous genes in E. coli. Specifically, the disclosed expression vector has the following elements in operable linkage: the PL6m promoter, the TAT32 ribosome binding site and a gene encoding a heterologous polypeptide, Also disclosed are E. coli host cells transformed with this expression vector.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: June 2, 1998
    Assignee: Pharmacia & UpJohn Company
    Inventors: Richard J. Kirschner, John Edward Mott, Frances M. Eckenrode, David Paul Brunner
  • Fermentation media and methods for controlling norleucine in polypeptides
    Patent number: 5698418
    Abstract: The present invention provides an inexpensive fermentation medium for growing microorganisms. Also provided are fermentation media and methods for producing norleucine by growing E. coli thereon, fermentation media and methods for incorporating norleucine into polypeptides expressed by microorganisms grown thereon, and fermentation media and methods for preventing the incorporation of norleucine into polypeptides expressed by microorganisms grown thereon. Also provided are bovine somatotropin analogs.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 16, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: David P. Brunner, Gary C. Harbour, Richard J. Kirschner, James F. Pinner, Robert L. Garlick
  • Fermentation method for producing norleucine
    Patent number: 5622845
    Abstract: The present invention provides an inexpensive fermentation medium for growing microorganisms. Also provided are fermentation media and methods for producing norleucine by growing E. coli thereon, fermentation media and methods for incorporating norleucine into polypeptides expressed by microorganisms grown thereon, and fermentation media and methods for preventing the incorporation of norleucine into polypeptides expressed by microorganisms grown thereon. Also provided are bovine somatotropin analogs.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 22, 1997
    Assignee: The Upjohn Company
    Inventors: David P. Brunner, Gary C. Harbour, Richard J. Kirschner, James F. Pinner, Robert L. Garlick
  • Eliminating internal initiation of soluble CD4 gene
    Patent number: 5510256
    Abstract: The present invention is based upon the discovery that proteins made from genes that include the CD4 sequence in its cDNA can make additional polypeptides as a result of internal translation initiation. This invention is thus directed to DNA sequences which eliminate internal initiation expression in sCD4.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: April 23, 1996
    Assignee: The Upjohn Company
    Inventors: Richard J. Kirschner, John E. Mott, Frances M. Eckenrode, David P. Brunner