Patents by Inventor Richard J. O'Brien

Richard J. O'Brien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10260097
    Abstract: Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: April 16, 2019
    Assignee: Almac Diagnostics Limited
    Inventors: Denis Paul Harkin, Fionnuala Patterson, Claire Trinder, Eamonn J. O'Brien, Caroline Michie, Charlie Gourley, Laura A. Hill, Katherine E. Keating, Jude O'Donnell, Max Bylesjo, Steve Deharo, Vitali Proutski, Richard Kennedy, Timothy Davison, Andreas Winter, Andrena McCavigan
  • Patent number: 10182729
    Abstract: The exemplary systems and methods may monitor one or more signals to be used to assess the hemodynamic status of a patient. The one or more signals may be used to calculate, or determine, a plurality of pulse transit times. The plurality of pulse transit times may be used to determine hemodynamic status values that may be indicative of a patient's aggregate hemodynamic status.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: January 22, 2019
    Assignee: Medtronics, Inc.
    Inventors: Todd M. Zielinski, David A. Anderson, Tom D. Bennett, James K. Carney, Can Cinbis, Yong K. Cho, Jonathan L. Kuhn, Brian B. Lee, Richard J. O'Brien, Eduardo N. Warman, Vinod Sharma
  • Publication number: 20180207429
    Abstract: In some examples, the disclosure describes an implantable medical device comprising a plurality of electrodes, sensing circuitry configured to sense a physiological electrical signal via the plurality of electrodes, and communication circuitry configured to transmit and/or receive a transconductance communication signal via the plurality of electrodes, wherein at least one electrode of the plurality of electrodes comprises a lower-capacitance portion and a higher-capacitance portion.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 26, 2018
    Inventors: James D. Reinke, James K. Carney, Can Cinbis, Richard J. O'Brien, Bushan Purushothaman
  • Patent number: 9999774
    Abstract: A medical device system is configured to sense a physiological signal by a first device and generate a control signal by the first device in response to the physiological signal. An optical transducer is controlled by the first device to emit an optical trigger signal in response to the control signal. A second device receives the optical trigger signal and delivers an automatic therapy to a patient in response to detecting the optical trigger signal.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: June 19, 2018
    Assignee: Medtronic, Inc.
    Inventors: Can Cinbis, Jonathan L. Kuhn, Richard J O'Brien, James K Carney
  • Patent number: 9958351
    Abstract: A pressure sensing system provides signals representative of a magnitude of pressure at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A calculated pressure, a bending pressure error and a bend-compensated pressure are computed in response to the first signal and the second signal.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: May 1, 2018
    Assignee: Medtronic, Inc.
    Inventors: Jonathan L. Kuhn, Richard J. O'Brien, Jonathan P. Roberts, James D. Reinke, Michael B. Terry, Kamal Deep Mothilal
  • Patent number: 9918638
    Abstract: Communication power in a medical device system is managed by providing power from a power supply to a communication circuit in a sensing device according to a first communication wake up mode set for a first time period and according to a second communication wake up mode set for a second time period. The second communication wake-up mode is established by a second device.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: March 20, 2018
    Assignee: Medtronic, Inc.
    Inventors: Can Cinbis, Michael A Schugt, Richard J O'Brien
  • Publication number: 20180055386
    Abstract: The exemplary systems and methods may monitor one or more signals to be used to assess the hemodynamic status of a patient. The one or more signals may be used to calculate, or determine, a plurality of pulse transit times. The plurality of pulse transit times may be used to determine hemodynamic status values that may be indicative of a patient's aggregate hemodynamic status.
    Type: Application
    Filed: August 31, 2016
    Publication date: March 1, 2018
    Inventors: Todd M. Zielinski, David A. Anderson, Tom D. Bennett, James K. Carney, Can Cinbis, Yong K. Cho, Jonathan L. Kuhn, Brian B. Lee, Richard J. O'Brien, Eduardo N. Warman, Vinod Sharma
  • Publication number: 20170164845
    Abstract: An implantable medical device, such as a sensor for monitoring a selected internally detectable physiological parameter of a patient, is attached to a fixation assembly that is deployable within the patient to position and orient the sensor to enable it to perform its function. The fixation assembly is formed having at least one flexible asymmetric connector where each fixation member includes a plurality of loops, wherein a first loop of the plurality of loops has a maximum pitch that is different from a maximum pitch of a second loop of the plurality of loops. The attachment of the housing and the fixation assembly includes providing a tubular member that is welded to the housing and crimped over a section of the fixation assembly.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 15, 2017
    Inventors: Michael P. Campbell, George Patras, Michael A. Schugt, Amir R. Zamiri, Richard J. O'Brien, Ruth N. Klepfer
  • Publication number: 20170140374
    Abstract: A network of registries is synchronized in whole or in part to a root registry; and are compilations of registrant data from accredited Identity Providers that accept liability for registering verified and accurate identity attributes. Registries associate a unique identifier with: a financial account owner's Personally Identifying Information; one or more linked publicly discoverable ePayment addresses to an account at a Financial Institution and a financial account owner's profile of preferences related to the capture, handling, transfer and storage of monetary and informational assets. Preferences extensions include: operating instructions and rule sets; and authentication factors that may make use of time sensitive data at one or more institutions.
    Type: Application
    Filed: December 13, 2016
    Publication date: May 18, 2017
    Inventors: Richard J. O'Brien, Andrew Gallant, Franco Modigliani, Francis M. Vitagliano
  • Patent number: 9636512
    Abstract: This disclosure provides an extravascular ICD system and method for defibrillating a heart of a patient. The extravascular ICD system includes multiple extravascular electrical stimulation leads or lead segments located in close proximity to one another and having respective defibrillation electrodes. The ICD system utilizes the multiple defibrillation electrodes to form an extravascular electrode vector that may result a reduction in the shock impedance and/or a reduction in the DFT compared to extravascular ICD systems that include only a single extravascular defibrillation electrode. An ICD of the system may, for example, deliver a defibrillation shock using an electrode vector in which a first polarity of the electrode vector is formed by electrically coupling first and second defibrillation electrodes of first and second leads, respectively, to the therapy circuitry and a second polarity of the electrode vector is formed by electrically coupling a housing of the ICD to the therapy circuitry.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: May 2, 2017
    Assignee: Medtronic, Inc.
    Inventors: Can Cinbis, Vladimir P. Nikolski, Jian Cao, James K. Carney, Melissa G. T. Christie, Richard J. O'Brien, Amy E. Thompson-Nauman
  • Publication number: 20170100036
    Abstract: Communication power in a medical device system is managed by providing power from a power supply to a communication circuit in a sensing device according to a first communication wake up mode set for a first time period and according to a second communication wake up mode set for a second time period. The second communication wake-up mode is established by a second device.
    Type: Application
    Filed: October 18, 2016
    Publication date: April 13, 2017
    Inventors: Can Cinbis, Michael A Schugt, Richard J O'Brien
  • Publication number: 20170025888
    Abstract: A rechargeable cell of an implantable medical device is recharged by an external charging unit that includes a transmitting coil configured to emit an electromagnetic field and a near-field focusing plate having a subwavelength structure pattern that focuses the emitted electromagnetic field to a focal pattern. The implantable medical device includes a housing having a window of an electromagnetically transparent material and a receiving coil enclosed by the housing. The receiving coil extends adjacent to and is aligned with the window. The rechargeable cell is enclosed by the housing and is configured to be charged by current induced in the receiving coil when the receiving coil is exposed to the focal pattern. In some examples, the near-field focusing plate is configured to produce the focal pattern to have a size that is less than an outer dimension of the window and a focal length from the near-field focusing plate that at least reaches the window.
    Type: Application
    Filed: July 18, 2016
    Publication date: January 26, 2017
    Inventors: Can Cinbis, Richard J O'Brien
  • Patent number: 9492671
    Abstract: A medical device system is configured to sense a physiological signal by a first device and generate a control signal by the first device in response to the physiological signal. An acoustical emitting device is controlled by the first device to emit an acoustical trigger signal in response to the control signal. A second device detects the acoustical trigger signal and delivers an automatic therapy to a patient in response to detecting the acoustical trigger signal.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: November 15, 2016
    Assignee: Medtronic, Inc.
    Inventors: Richard J O'Brien, James K Carney, Can Cinbis, Jonathan L Kuhn, Thomas A Anderson, Taylor R Anderson
  • Patent number: 9431312
    Abstract: A medical device includes a first substrate, a second substrate, a control module, and an energy storage device. The first substrate includes at least one of a first semiconductor material and a first insulating material. The second substrate includes at least one of a second semiconductor material and a second insulating material. The second substrate is bonded to the first substrate such that the first and second substrates define an enclosed cavity between the first and second substrates. The control module is disposed within the enclosed cavity. The control module is configured to at least one of determine a physiological parameter of a patient and deliver electrical stimulation to the patient. The energy storage device is disposed within the cavity and is configured to supply power to the control module.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: August 30, 2016
    Assignee: Medtronic, Inc.
    Inventors: Richard J O'Brien, John K Day, Paul F Gerrish, Michael F Mattes, David A Ruben, Malcolm K Grief
  • Publication number: 20160204004
    Abstract: A medical device includes a first substrate, a second substrate, a control module, and an energy storage device. The first substrate includes at least one of a first semiconductor material and a first insulating material. The second substrate includes at least one of a second semiconductor material and a second insulating material. The second substrate is bonded to the first substrate such that the first and second substrates define an enclosed cavity between the first and second substrates. The control module is disposed within the enclosed cavity. The control module is configured to at least one of determine a physiological parameter of a patient and deliver electrical stimulation to the patient. The energy storage device is disposed within the cavity and is configured to supply power to the control module.
    Type: Application
    Filed: March 24, 2016
    Publication date: July 14, 2016
    Inventors: Richard J. O'Brien, John K. Day, Paul F. Gerrish, Michael F. Mattes, David A. Ruben, Malcolm K. Grief
  • Publication number: 20160121130
    Abstract: This disclosure provides an extravascular ICD system and method for defibrillating a heart of a patient. The extravascular ICD system includes multiple extravascular electrical stimulation leads or lead segments located in close proximity to one another and having respective defibrillation electrodes. The ICD system utilizes the multiple defibrillation electrodes to form an extravascular electrode vector that may result a reduction in the shock impedance and/or a reduction in the DFT compared to extravascular ICD systems that include only a single extravascular defibrillation electrode. An ICD of the system may, for example, deliver a defibrillation shock using an electrode vector in which a first polarity of the electrode vector is formed by electrically coupling first and second defibrillation electrodes of first and second leads, respectively, to the therapy circuitry and a second polarity of the electrode vector is formed by electrically coupling a housing of the ICD to the therapy circuitry.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 5, 2016
    Inventors: Can CINBIS, Vladimir P. NIKOLSKI, Jian CAO, James K. CARNEY, Melissa G.T. CHRISTIE, Richard J. O'BRIEN, Amy E. THOMPSON-NAUMAN
  • Patent number: 9318400
    Abstract: A medical device includes a first substrate, a second substrate, a control module, and an energy storage device. The first substrate includes at least one of a first semiconductor material and a first insulating material. The second substrate includes at least one of a second semiconductor material and a second insulating material. The second substrate is bonded to the first substrate such that the first and second substrates define an enclosed cavity between the first and second substrates. The control module is disposed within the enclosed cavity. The control module is configured to at least one of determine a physiological parameter of a patient and deliver electrical stimulation to the patient. The energy storage device is disposed within the cavity and is configured to supply power to the control module.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: April 19, 2016
    Assignee: Medtronic, Inc.
    Inventors: Richard J. O'Brien, John K. Day, Paul F. Gerrish, Michael F. Mattes, David A. Ruben, Malcolm K. Grief
  • Publication number: 20160034896
    Abstract: The present invention relates to a network of registries that are: synchronized in whole or in part to a root registry; and are compilations of registrant data from accredited Identity Providers that accept liability for registering verified and accurate identity attributes. Registries associate a unique identifier with: a financial account owner's Personally Identifying Information; one or more linked publicly discoverable ePayment addresses to an account at a Financial Institution and a financial account owner's profile of preferences related to the capture, handling, transfer and storage of monetary and informational assets. Preferences extensions include: operating instructions and rule sets; and authentication factors that may make use of time sensitive data at one or more institutions.
    Type: Application
    Filed: October 14, 2015
    Publication date: February 4, 2016
    Inventors: Richard J. O'Brien, Andrew Gallant
  • Publication number: 20150321012
    Abstract: A medical device system is configured to sense a physiological signal by a first device and generate a control signal by the first device in response to the physiological signal. An optical transducer is controlled by the first device to emit an optical trigger signal in response to the control signal. A second device receives the optical trigger signal and delivers an automatic therapy to a patient in response to detecting the optical trigger signal.
    Type: Application
    Filed: April 23, 2015
    Publication date: November 12, 2015
    Inventors: Can Cinbis, Jonathan L. Kuhn, Richard J. O'Brien, James K. Carney
  • Publication number: 20150321016
    Abstract: A medical device system is configured to sense a physiological signal by a first device and generate a control signal by the first device in response to the physiological signal. An acoustical emitting device is controlled by the first device to emit an acoustical trigger signal in response to the control signal. A second device detects the acoustical trigger signal and delivers an automatic therapy to a patient in response to detecting the acoustical trigger signal.
    Type: Application
    Filed: April 23, 2015
    Publication date: November 12, 2015
    Inventors: Richard J O'Brien, James K Carney, Can Cinbis, Jonathan L Kuhn, Thomas A Anderson, Taylor R Anderson