Abstract: A method and computing system for prescription drug management program reporting can include receiving laboratory test results corresponding to a patient and being indicative of a toxicology screen of the patient. Controlled substance prescription data for the patient can be retrieved from a prescription drug management program data source and can include prescriptions of controlled substances issued to the patient for a relevant time period. The controlled substance prescription data and the laboratory test results can be analyzed to determine a daily morphine milligram equivalent of the patient for a given time period, an overdose risk score, and a drug consistency assessment. An enhanced toxicology report based on the determined daily morphine milligram equivalent of the patient for the given time period, the overdose risk score, and the drug consistency assessment can be generated output to a requestor computing device.