Patents by Inventor Richard J. Payne

Richard J. Payne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230416341
    Abstract: The invention relates to the treatment of thromboembolic conditions, to fibrin clot formation and related thrombin activity, and to preparation of compounds, in particular, peptides and polypeptides for inhibiting, or for modifying the cleavage of fibrinogen by thrombin.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 28, 2023
    Applicants: THE UNIVERSITY OF SYDNEY, THE HEART RESEARCH INSTITUTE LTD
    Inventors: Richard J PAYNE, Emma WATSON, Shaun Phillip JACKSON
  • Publication number: 20230133885
    Abstract: The disclosure relates to the synthesis of amide containing compounds inflow. In particular, the disclosure relates to the synthesis of polypeptides via native chemical ligation inflow. The disclosure also relates to selective desulfurization or deselenization of amide containing compounds comprising a thiol, disulfide, selenol or diselenide functional group respectively, particularly polypeptides.
    Type: Application
    Filed: May 22, 2019
    Publication date: May 4, 2023
    Applicant: The University of Sydney
    Inventors: Richard J. PAYNE, Tim CHISHOLM
  • Publication number: 20230002446
    Abstract: The invention relates to anti-inflammatory peptides, to pharmaceutical compositions comprising same and to uses thereof for treatment of inflammation including, but not limited to inflammation associated with immune activation.
    Type: Application
    Filed: June 5, 2020
    Publication date: January 5, 2023
    Inventors: Richard J. PAYNE, Scott N. BYRNE, David M. McDONALD, Anneliese S. ASHHURST
  • Patent number: 11091535
    Abstract: The treatment of stroke related diseases are described herein. In addition, fibrin clot formation and related activity is proposed for the disclosed compounds, in particular, peptides for inhibiting or modifying the cleavages of fibrinogen by thrombin. Methods for producing such compounds are also disclosed.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 17, 2021
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Richard J. Payne, Shaun Phillip Jackson, Pedro Jose Barbosa Pereira
  • Publication number: 20190367583
    Abstract: The invention relates to the treatment of stroke and related diseases, to fibrin clot formation and related thrombin activity, and to preparation of compounds, in particular, peptides and polypeptides for inhibiting, or for modifying the cleavage of fibrinogen by thrombin.
    Type: Application
    Filed: December 15, 2017
    Publication date: December 5, 2019
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Richard J. PAYNE, Shaun Phillip JACKSON, Pedro Jose BARBOSA PEREIRA
  • Publication number: 20160122383
    Abstract: The invention relates to a process for introducing a thiol group a to a carbonyl group in a side chain of a protected a-amino acid, said protected a-amino acid having protecting groups on both the ?-amine group and the a-carboxyl group. The process comprises a) if the side chain contains a functional group comprising a heteroatom bearing a hydrogen atom, protecting said functional group; b) treating the protected amino acid with a base of sufficient strength to abstract a hydrogen atom a to the carbonyl group, so as to form an anion; c) treating the anion with a reagent of structure Pr-S-L in which L is a leaving group and Pr is a thiol-protecting group, so as to introduce a Pr-S- group a to the carbonyl group; and d) converting the Pr-S- group to an H-S-(thiol) group. This process may be used to prepare ligated peptides.
    Type: Application
    Filed: June 4, 2014
    Publication date: May 5, 2016
    Inventors: Richard J. Payne, Robert E. Thompson
  • Patent number: 4296840
    Abstract: A tractor pull sled including a weighted pan movably supported on a frame intermediate the forward and rearward ends. The frame is supported by a plurality of ground engaging wheels, at least one of which is coupled to and actuates a pan support assembly which transfers the weight of the pan to the ground at a rate which is a function of the distance of forward travel of the sled. The pan support assembly also functions to transfer the weight of the frame onto the pan after the full weight of the pan has been applied to the ground.
    Type: Grant
    Filed: October 11, 1979
    Date of Patent: October 27, 1981
    Inventor: Richard J. Payne