Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: A floss device is disclosed which is designed to be used to floss between adjacent teeth in a person's mouth. The floss device includes a first portion joined to a second portion. The first portion has an arcuate configuration which terminates in a rounded tip. The second portion is linear and terminates in an enlarged distal end which is designed to be grasped between a person's thumb and index finger and facilitates manipulation of said floss device. The floss device also has a textured outer surface that can temporarily retain a solution or liquid medication and then transfer the solution or liquid medication onto the teeth and surrounding soft tissue in a person's mouth. A method of molding the floss device and a method of using the floss device are also disclosed.

Abstract: A floss device is disclosed which is designed to be used to floss between adjacent teeth in a person's mouth. The floss device includes a first portion joined to a second portion. The first portion has an arcuate configuration which terminates in a rounded tip. The second portion is linear and terminates in an enlarged distal end which is designed to be grasped between a person's thumb and index finger and facilitates manipulation of said floss device. The floss device also has a textured outer surface that can temporarily retain a solution or liquid medication and then transfer the solution or liquid medication onto the teeth and surrounding soft tissue in a person's mouth. A method of molding the floss device and a method of using the floss device are also disclosed.

Abstract: A dental probe is disclosed which is designed to be used to probe around and between teeth and surrounding soft tissue in a person's mouth. The dental probe has an arcuately shaped first portion terminating in a blunt tip and a second portion secured to the first portion opposite the tip. The dental probe also has a textured outer surface. The dental probe is capable of transferring a solution or liquid medication onto the teeth and surrounding soft tissue in a person's mouth. A method of molding the dental probe and a method of using the dental probe are also disclosed.

Abstract: A toothpick probe molded of nylon 6 material and containing absorbed polar mouthwash antiseptic/antibacterial solution for probing between human teeth and probing of the gums holding the human teeth. The toothpick probe molded of nylon 6 material is captured immediately on ejection from the molding cavities and immersed in a polar antiseptic mouthwash solution and subsequently removed from the solution and free liquid removed from the toothpick probes for subsequent use of the toothpick probes, as a toothpick probe for human teeth and gums holding the teeth and in addition a molded nylon 6 material is captured and immersed in a polar solution of antiseptic/antibacterial for a sufficient time to absorb at least 10% of its weight of the antiseptic/antibacterial solution and a section of the molded nylon 6 material containing the absorbed polar antiseptic/antibacterial liquid, for in vivo application.

Abstract: Portable locker apparatus is disclosed comprising three parts or components which includes a locker body formed of plastic material a tray for holding beverage cans placed horizontally on wave form ridges in the tray, and a carrying bag fitting around the portable locker apparatus, and in this first embodiment a cable fitting in slots in the portable locker apparatus with a padlock connecting eyelets on the cable ends and to anchor the whole assembly as needed. The second embodiment excludes the cable and slots but includes all other components of the portable locker apparatus, beverage tray and carrying bag.

Abstract: An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P−diastolic P), and/or dP/dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (&tgr;); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (EES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level.

Abstract: Medical device data is transferred using a universal adaptor between an implanted medical device and hospital monitoring systems. The universal adaptor is an interface compatible with various built-in hospital monitoring network comprised of equipment from a variety of manufacturers. The universal adaptor includes a telemetry circuitry, a calibration system for atmospheric pressure and an analog interface. The calibration system relates to barometric correction and includes an external pressure reference system.

Abstract: An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P−diastolic P), and/or dP/dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (&tgr;); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (EES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level.

Abstract: A vehicle fuel or gas tank is subject to either a build up of pressure or a negative pressure, and in view of this inlet and outlet vents are provided in the fuel cap to balance the pressure with the atmosphere, and this balance of fuel tank pressure is attained by covers of vents in the fuel cap and the covers having an umbrella or parabolic shape or the vents may be covered by reed valves. The disclosure of covers of vents as described in this invention then obviates the use of coiled metal springs to control vents in vehicle fuel caps.

Abstract: Medical device data is transferred using a universal adaptor between an implanted medical device and hospital monitoring systems. The universal adaptor is an interface compatible with various built-in hospital monitoring network comprised of equipment from a variety of manufacturers. The universal adaptor includes a telemetry circuitry, a calibration system for atmospheric pressure and an analog interface. The calibration system relates to barometric correction and includes an external pressure reference system.

Abstract: Proper mounting of a motor vehicle fuel tank cap on a vehicle fill pipe is of major importance to reduce the vapors which on escaping from the fuel tank contributes to environ-mental pollution, to insure proper mounting of the gas cap there is provided in this invention apparatus and method for monitoring proper mounting of the motor vehicle fuel tank cap, on the fill pipe of the vehicle and the apparatus includes strain gauges, connected to a monitor computer and an alarm activated by the monitor computer to indicate proper or improper mounting of the fuel tank cap on the fill pipe of the vehicle fuel tank.

Abstract: This invention discloses, as a manufacture, a vehicle O ring fuel cap gasket having a diagonally inverted modified C shape cross section and a groove extending for the full circumference of the O ring and in cross section the groove edges extend downward, with one or first edge extending downward to about 4 o'clock position and the other or second edge extending downward to about 7:30 o'clock, to provide a groove opening extending diagonally upwards for a depth of about 2.2.times. to about 2.5.times. the thickness T-T' of the back of the C shape, and optional ridges on the outer circumference, the inner circumference, or the top of the O ring, and the O ring formed of an elastomer having a Shore A hardness about 50 to 60 and ultimate elongation range of 200% to 315%.

Abstract: Automobile gas cap removal tool, formed of plastic or aluminum and the tool has a bell shape with channels formed by wall segments on the inside of the bell shaped segment and a pillar or shaft extending from the top of the bell segment to a handle mounted on the opposite end of the pillar extending from the bell segment.

Abstract: An end brush for use in a dental unit or the like includes a base formed of solified fiber material. The base includes an outwardly projecting portion, which is adapted to be received within a mounting structure provided on the dental unit. An apparatus and method for forming the end brush are disclosed.

Abstract: An end brush for use in a dental unit or the like includes a base formed of solified fiber material. The base includes an outwardly projecting portion, which is adapted to be received within a mounting structure provided on the dental unit. An apparatus and method for forming the end brush are disclosed.

Abstract: An end brush for use in a dental unit or the like includes a base formed of solified fiber material. The base includes an outwardly projecting portion, which is adapted to be received within a mounting structure provided on the dental unit. An apparatus and method for forming the end brush are disclosed.

Abstract: A vehicle fuel or gas tank is subjected to either a build up of pressure or a negative pressure, and in view of this inlet and outlet vents are provided in the fuel cap to balance the pressure with the atmosphere, and this balance of fuel tank pressure is attained by covers of vents in the fuel cap and the covers having an umbrella or parabolic shape or the vents may be covered by reed valves. The disclosure of covers of vents as described in this invention then obviates the use of coiled metal springs to control vents in vehicle fuel caps.