Patents by Inventor Richard J. St. John

Richard J. St. John has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for protein refolding
    Patent number: 8329878
    Abstract: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: December 11, 2012
    Assignee: Barofold Inc.
    Inventors: Theodore W. Randolph, John F. Carpenter, Richard J. St. John, Jonathan N. Webb
  • METHODS FOR PROTEIN REFOLDING
    Publication number: 20100075399
    Abstract: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
    Type: Application
    Filed: April 17, 2009
    Publication date: March 25, 2010
    Inventors: Theodore W. RANDOLPH, John F. Carpenter, Richard J. St. John, Jonathan N. Webb
  • Methods for protein refolding
    Patent number: 7538198
    Abstract: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: May 26, 2009
    Assignee: Barofold, Inc.
    Inventors: Theodore W. Randolph, John F. Carpenter, Richard J. St. John, Jonathan N. Webb
  • Methods for protein refolding
    Publication number: 20040038333
    Abstract: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
    Type: Application
    Filed: April 26, 2003
    Publication date: February 26, 2004
    Inventors: Theodore W. Randolph, John F. Carpenter, Richard J. St.John, Jonathan N. Webb