Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: Embodiments of an adapter, a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter may include a body having a first port configured to connect with a first container to receive a first substance, a second port configured to connect with a second container to receive a second substance, a third port configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.

Abstract: A pulse transit time is measured non-invasively and used to calculate a blood pressure value. A method of determining one or more blood pressure values includes propagating an alternating drive current through a thorax of a subject via electrodes located on a wrist-worn device. Resulting voltage levels of the subject are sensed by the wrist-worn device. The voltage levels are processed to detect when a volume of blood is ejected from the left ventricle. Output from a pulse arrival sensor coupled to the wrist-worn device is processed to detect when a blood pressure pulse generated by ejection of the volume of blood from the left ventricle arrives at the wrist. A pulse transit time (PTT) for transit of the blood pressure pulse from the left ventricle to the wrist is calculated. One or more blood pressure values for the subject are determined based on the PTT.

Abstract: a sound control device for pneumatically driven mechanical devices and method of use of said device, the device configured to create a sealed intermediary gas medium between the atmosphere and surfaces of the pneumatically driven mechanical device where vibrational energy is generated and where exhaust flow travels, the sound control device further configured to carry such energy and exhaust away from the source where it may be released into the atmosphere in a quieter manner.

Abstract: This invention relates to oral care compositions comprising an effective amount of a basic amino acid in free or salt form, together with an antibacterial agent, and to methods of using and of making such compositions.

Abstract: The present invention is directed to effervescent compositions comprising a basic amino acid.

Abstract: The application discloses dentifrice compositions comprising arginine together with fluoride, phosphate and pyrophosphate salts, in a dentifrice base with a calcium-free silica abrasive, which compositions provide enhanced remineralization, together with methods of using and of making these compositions.

Abstract: The present invention is directed to methods and compositions comprising a basic amino acid, e.g., arginine, for the treatment of dry mouth.

Abstract: The invention provides a method of treating sensitive teeth comprising attaching a sealant composition comprising a basic amino acid to a person's tooth and allowing the basic amino acid to be slowly released over time in order to reduce chrome and/or acute tooth sensitivity together with compositions and methods of use.

Abstract: The present invention provides oral instruments comprising a basic amino acid, to compositions for making such instruments, and to methods of making and using such instruments.

Abstract: The present invention provides tooth-whitening compositions comprising a bleaching agent and a basic amino acid, together with devices for application thereof, and methods of use therefor.

Abstract: This invention relates to oral care compositions comprising a basic amino acid or salt thereof, and a small particle fraction: and to methods of using and of making these compositions.

Abstract: This invention relates to oral care compositions comprising an effective amount of a salt of a basic amino acid the salt having a pH in an unbuffered solution of less than about 7.5; an effective amount of a soluble fluoride salt; and a particulate material which has a pH in an unbuffered solution of less than about 7.5; and to methods of using and of making such compositions.

Abstract: The application discloses dentifrice compositions comprising arginine together with fluoride, phosphate and pyro-phosphate salts, in a dentifrice base with a calcium-free silica abrasive, which compositions provide enhanced remineralization, together with methods of using and of making these compositions.

Abstract: The invention provides a method of measuring ammonia and/or calcium in a sample of dental plaque, comprising obtaining the sample of plaque and measuring ammonium and calcium ions using capillary electrophoresis, together with methods of diagnosis, treatment and screening based on evaluation of plaque.

Abstract: An apparatus for grasping a cooking receptacle comprises a handle portion comprising an upper arm and a lower arm, the upper arm comprising an upper distal end and an upper proximal end, and the lower arm comprising a lower distal end and a lower proximal end; a hinge member connecting the upper proximal end of the upper arm to the lower proximal end of the lower arm; and a clamping portion comprising, a head portion, a holding member and a supporting member, the head portion disposed at the upper distal end of the upper arm, the holding member disposed on the head portion comprising a receiving groove, and the supporting member disposed on the lower distal end of the lower arm comprising a supporting surface.

Abstract: An oral care composition comprises xylitol and a water-soluble calcium salt for caries prevention. Methods of treating and preventing dental caries are also provided.