Patents by Inventor Richard J. Whitbourne
Richard J. Whitbourne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20130253636Abstract: This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.Type: ApplicationFiled: October 15, 2012Publication date: September 26, 2013Applicant: ANGIOTECH BIOCOATINGS CORP.Inventors: Richard J. Whitbourne, Alexandra M. Chamberlain, Daniel G. Hullihen, Scott F. Rosebrough, Mildred Calistri-Yeh
-
Patent number: 8287590Abstract: This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.Type: GrantFiled: July 1, 2010Date of Patent: October 16, 2012Inventors: Richard J. Whitbourne, Alexandra M. Chamberlain, Daniel G. Hullihen, Scott F. Rosebrough, Mildred Calistri-Yeh
-
Patent number: 8101200Abstract: Generally, the present invention provides devices and methods for delivering high, efficacious concentrations of therapeutic agents, i.e., medicaments such as drugs, antibiotics, etc., to specific sites in a patient's body, such as tumors and infected lesions. In one aspect of the present invention there are provided devices to accomplish the aforesaid delivery of therapeutic agents and methods to accomplish the delivery by positioning a device in the body using minimally invasive techniques such as, for example, catheterization or via trochar. The devices may contain a carrier substrate and a coating on the substrate. The carrier substrate provides structural integrity to the device and the coating thereon contains at least one layer of polymeric material containing one or more medicaments. Optionally, there may be a non-medicated binder coat between the carrier substrate and the medicated polymer layer. The medicated polymer layer may contain a hydrophilic/hydrophobic polymer composition.Type: GrantFiled: April 12, 2001Date of Patent: January 24, 2012Inventors: Richard J. Whitbourne, Daniel Hullihen, Michael R. Violante, Frank Guo-Bin Wang, Xianping Zhang
-
Publication number: 20100331967Abstract: This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.Type: ApplicationFiled: July 1, 2010Publication date: December 30, 2010Applicant: Angiotech Biocoatings Corp.Inventors: Richard J. WHITBOURNE, Alexandra M. CHAMBERLAIN, Daniel G. HULLIHEN, Scott F. ROSEBROUGH, Mildred CALISTRI-YEH
-
Patent number: 7771468Abstract: This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.Type: GrantFiled: September 16, 2003Date of Patent: August 10, 2010Assignee: Angiotech BioCoatings Corp.Inventors: Richard J. Whitbourne, Alexandra M. Chamberlain, Daniel G. Hullihen, Scott F. Rosebrough, Mildred Calistri-Yeh
-
Publication number: 20090048537Abstract: Medical devices can include a lubricious coating that is slippery when wet.Type: ApplicationFiled: January 31, 2007Publication date: February 19, 2009Applicant: ANGIOTECH BIOCOATINGS CORP.Inventors: Margaret Lydon, Rui Avelar, Richard J. Whitbourne, Donald M. Copenhagen, Kristy Jackson, Martin Jay Kozlowski
-
Patent number: 7229413Abstract: An ultrasonically visible solid device for inserting into a non-gas target medium comprises an echogenic surface having structures entrapping gas when the device is in the target medium, the entrapped gas causing the device to be ultrasonically visible, wherein the gas-entrapping structures are covered with a flexible overcoat that does not significantly reduce the compressibility of the gas trapped in the structures.Type: GrantFiled: August 25, 2003Date of Patent: June 12, 2007Assignee: Angiotech Biocoatings Corp.Inventors: Michael R. Violante, Richard J. Whitbourne, John F. Lanzafame, Margaret Lydon
-
Publication number: 20040117007Abstract: This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.Type: ApplicationFiled: September 16, 2003Publication date: June 17, 2004Applicant: STS Biopolymers, Inc.Inventors: Richard J. Whitbourne, Alexandra M. Chamberlain, Daniel G. Hullihen, Scott F. Rosebrough, Mildred Calistri-Yeh
-
Publication number: 20040077948Abstract: An ultrasonically visible solid device for inserting into a non-gas target medium comprises an echogenic surface having structures entrapping gas when the device is in the target medium, the entrapped gas causing the device to be ultrasonically visible, wherein the gas-entrapping structures are covered with a flexible overcoat that does not significantly reduce the compressibility of the gas trapped in the structures.Type: ApplicationFiled: August 25, 2003Publication date: April 22, 2004Applicant: STS Biopolymers, Inc.Inventors: Michael R. Violante, Richard J. Whitbourne, John F. Lanzafame, Margaret Lydon
-
Patent number: 6610016Abstract: Coatings to enhance the echogenicity of materials are especially useful for medical devices wherein the practitioner desires to locate or visualize a device by ultrasonic imaging when the device is inserted into a body cavity. These coatings can be applied to any device of virtually any composition. To accomplish this, a polymer matrix is formed containing an entrapped gas in enclosed bubbles or open surface channels or cavities. Coated needles are visible in ultrasound when inserted in animals. A pre-coat or base coat may be applied to condition the surface to enhance adhesion. A finish coat or top coat may be applied to improve durability, smoothness, and biocompatibility, lubricity, antibiotic, antimicrobial, antithrombogenic activity, and other desirable properties for the finished product. Coating liquids and methods for preparing and applying such coatings are disclosed, including forming bubbles by chemical reaction during the coating process.Type: GrantFiled: August 4, 1999Date of Patent: August 26, 2003Assignee: STS Biopolymers, Inc.Inventors: Michael R. Violante, Richard J. Whitbourne, John F. Lanzafame, Margaret Lydon
-
Patent number: 6368611Abstract: A part that can be introduced and/or implanted in the body, in body parts, or in body cavities, made of nonmetallic material or having a nonmetallic surface is designed such that infections associated with the use of parts of this type are reduced or entirely eliminated. This is achieved due to the fact that the entire surface of this part or parts or, depending on the effect, partial areas of this part or parts, that are nevertheless not in geometric contact, is/are furnished with a metallization (6). It is also possible that the material at least in the area of its exterior surface (17) contains metallic particles (18) in powder or granular form made of a metal having an oligodynamic effect, and that the most exterior metallic particles (18) are uncovered at least partially at the surface.Type: GrantFiled: August 31, 1999Date of Patent: April 9, 2002Assignee: STS Biopolymers, Inc.Inventors: Richard J. Whitbourne, Xianping Zhang
-
Publication number: 20020018795Abstract: Generally, the present invention provides devices and methods for delivering high, efficacious concentrations of therapeutic agents, i.e., medicaments such as drugs, antibiotics, etc., to specific sites in a patient's body, such as tumors and infected lesions. In one aspect of the present invention there are provided devices to accomplish the aforesaid delivery of therapeutic agents and methods to accomplish the delivery by positioning a device in the body using minimally invasive techniques such as, for example, catheterization or via trochar. The devices may contain a carrier substrate and a coating on the substrate. The carrier substrate provides structural integrity to the device and the coating thereon contains at least one layer of polymeric material containing one or more medicaments. Optionally, there may be a non-medicated binder coat between the carrier substrate and the medicated polymer layer. The medicated polymer layer may contain a hydrophilic/hydrophobic polymer composition.Type: ApplicationFiled: April 12, 2001Publication date: February 14, 2002Inventors: Richard J. Whitbourne, Daniel Hullihen, Michael R. Violante, Frank Guo-Bin Wang, Xianping Zhang
-
Patent number: 6306176Abstract: The medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers containing hydroxyl, amine, carboxyl, amide or other reactive groups, and copolymers thereof. Outer layers may be applied and remain adherent to the substrate in water for an extended period. The bond coat may comprise cross linkers such as urea resins, melamines, isocyanates, and phenolics. Preferred polymers include vinylpyrrolidone-vinyl acetate, styrene acrylic polymer, ethylene acrylic acid copolymer, carboxyl function acrylic polymer, hydroxyl function acrylic polymer, and acrylic dispersion polymer. The coatings may be applied to inert metal or plastic surfaces of medical devices such as needles, guide wires, catheters, surgical instruments, equipment for endoscopy, wires, stents, angioplasty balloons, wound drains, arteriovenous shunts, gastroenteric tubes, urethral inserts, laparoscopic equipment, pellets, and implants. Methods of coating and coating liquids are provided.Type: GrantFiled: September 21, 1999Date of Patent: October 23, 2001Assignee: STS Biopolymers, Inc.Inventor: Richard J. Whitbourne
-
Patent number: 6110483Abstract: The adherent coating of the invention comprises a stabilizing polymer together with an active agent (a hydrophilic polymer and/or a bioactive agent) in a layer bonded to the surface of a medical device. This invention encompasses the coating liquids used for coating medical devices, methods of coating the devices, and the coated devices. The stabilizing polymer is selected to entrap the active agent in a coating that has a high degree of flexibility and has improved bonding to a wide variety of substrates. Preferred stabilizing polymers are cross-linkable acrylic and methacrylic polymers, ethylene acrylic acid copolymers, styrene acrylic copolymers, vinyl acetate polymers and copolymers, vinyl acetal polymers and copolymers, epoxy, melamine, other amino resins, phenolic polymers, copolymers thereof, and combinations.Type: GrantFiled: June 23, 1997Date of Patent: August 29, 2000Assignee: STS Biopolymers, Inc.Inventors: Richard J. Whitbourne, Xianping Zhang
-
Patent number: 6106473Abstract: Coatings to enhance the echogenicity of materials are especially useful for medical devices wherein the practitioner desires to locate or visualize a device by ultrasonic imaging when the device is inserted into a body cavity. These coatings can be applied to any device of virtually any composition. To accomplish this, a polymer matrix is formed containing an entrapped gas in enclosed bubbles or open surface channels or cavities. Coated needles are visible in ultrasound when inserted in animals. A pre-coat or base coat may be applied to condition the surface to enhance adhesion. A finish coat or top coat may be applied to improve durability, smoothness, and biocompatibility, lubricity, antibiotic, antimicrobial, antithrombogenic activity, and other desirable properties for the finished product. Coating liquids and methods for preparing and applying such coatings are disclosed, including forming bubbles by chemical reaction during the coating process.Type: GrantFiled: November 6, 1997Date of Patent: August 22, 2000Assignee: STS Biopolymers, Inc.Inventors: Michael R. Violante, Richard J. Whitbourne, John F. Lanzafame, Margaret Lydon
-
Patent number: 5997517Abstract: A medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers, polymers containing hydroxyl, amine, carboxyl, amide, or other reactive groups, and copolymers thereof. Outer layers may be applied and remain adherent to the substrate in water for an extended period. The bond coat may comprise cross linkers such as urea resins, melamines, isocyanates, and phenolics. Preferred polymers include vinylpyrrolidone-vinyl acetate, styrene acrylic polymer, ethylene acrylic acid copolymer, carboxyl function acrylic polymer, hydroxyl function acrylic polymer, and acrylic dispersion polymer. The coatings may be applied to inert metal or plastic surfaces of medical devices such as needles, guide wires, catheters, surgical instruments, equipment for endoscopy, wires, stents, angioplasty balloons, wound drains, arteriovenous shunts, gastroenteric tubes, urethral inserts, laparoscopic equipment, pellets, and implants.Type: GrantFiled: January 27, 1997Date of Patent: December 7, 1999Assignee: STS Biopolymers, Inc.Inventor: Richard J. Whitbourne
-
Patent number: 5800412Abstract: According to the invention, hydrating agents in ultrafine form may be incorporated in an organic coating solution with a uniform distribution that does not change due to settling. In preferred embodiments, the coating solution comprises salt dissolved in an appropriate organic solvent blend. In another embodiment, the hydrating agent may be in the form of ultrafine particles dispersed in the polymer solution. The dispersion may be obtained by adding a stream of the aqueous hydrating agent solution to the organic polymer solution in a controlled fashion, or salt particles may be formed in the polymer solution by acid-base neutralization in solution. The coating solutions are storage stable. When applied to a medical device, the coating solution produces a homogenous coating with desirable performance characteristics. The coatings of the invention adhere to the substrate but not to moist tissue with which they are placed in contact.Type: GrantFiled: October 10, 1996Date of Patent: September 1, 1998Assignee: STS Biopolymers, Inc.Inventors: Xianping Zhang, Richard J. Whitbourne
-
Patent number: 5525348Abstract: Anti-thrombogenic, and/or anti-microbial and/or pharmaceutical compositions containing heparin and/or antibiotics and/or other pharmaceutical agents which may be reacted with quaternary ammonium components or other ionic surfactants and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds or other ionic surfactants not reacted with heparin and may also contain quaternary ammonium compound(s) or other ionic surfactants reacted with antibiotics or other ionic or nonionic pharmaceutical agents.Type: GrantFiled: November 2, 1994Date of Patent: June 11, 1996Assignee: STS Biopolymers, Inc.Inventors: Richard J. Whitbourne, Margaret A. Mangan
-
Patent number: 5331027Abstract: The lubricious hydrophilic coatings of the invention are significantly more lubricious when wet than when dry, are adherent to a variety of substrates, and are resistant to removal by wet abrasion. In one embodiment, the coatings include a hydrophilic polyolefin such as polyvinyl-pyrrolidone and a water-insoluble stabilizing polymer such as a cellulose ester. The coatings may also include an adherent polymer and a plasticizing agent. The coating may be applied by preparing a solution of the stabilizing polymer and a solution of the hydrophilic polyolefin, and coating the substrate first in one then the other. Alternatively, both the stabilizing and hydrophilic polymers may be dissolved in a single solvent system and applied to the substrate in a single step. In another embodiment, only a solution of a hydrophilic polyolefin is applied directly to the substrate.Type: GrantFiled: May 25, 1993Date of Patent: July 19, 1994Assignee: Sterilization Technical Services, Inc.Inventor: Richard J. Whitbourne
-
Patent number: 5069899Abstract: Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds not reacted with heparin and may also contain quaternary ammonium compound(s) reacted with antibiotics.Type: GrantFiled: November 2, 1989Date of Patent: December 3, 1991Assignee: Sterilization Technical Services, Inc.Inventors: Richard J. Whitbourne, Margaret A. Mangan