Patents by Inventor Richard James Lewis
Richard James Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120277166Abstract: The invention relates to an isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them.Type: ApplicationFiled: May 25, 2011Publication date: November 1, 2012Applicant: XENOME LIMITEDInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe
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Patent number: 8188048Abstract: The present invention relates generally to methods for inducing, promoting or otherwise facilitating pain relief. More particularly, the present invention relates to a synergistic combination of a selective inhibitor of the neuronal norepinephrine transporter and an analgesic agent in the therapeutic management of vertebrate animals, including humans, for producing analgesia or for the prevention or alleviation of pain.Type: GrantFiled: June 22, 2007Date of Patent: May 29, 2012Assignee: Xenome LimitedInventor: Richard James Lewis
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Publication number: 20110195909Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO: 3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not Mr1A, Mr1B, Mar2, CMrV1A, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: ApplicationFiled: March 18, 2011Publication date: August 11, 2011Applicant: XENOME LTD.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Patent number: 7851444Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide comprising the following sequence of amino acids: Xaa1 Xaa2 Gly Val Cys Cys Gly Tyr Lys Leu Cys His Pro Cys SEQ ID NO. 3 where Xaa1 is a N-terminal Xaa1 is a N-terminal pyroglutamate (pGlu) or D-pyroglutamate (DpGlu) residue; and Xaa2 is Asn or a deletion; or such a sequence in which one or more Cys is replaced with its corresponding D-amino acid and/or one or more amino acid residues other than Cys has undergone a side chain modification, or a salt, ester, amide or prodrug thereof. The invention also relates to pharmaceutical compositions comprising these peptides and the use of these peptides in the prophylaxis or treatment of conditions, such as but not limited to, pain, inflammation, incontinence, cardiovascular conditions and mood disorders.Type: GrantFiled: December 2, 2003Date of Patent: December 14, 2010Assignee: Xenome Ltd.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Publication number: 20090275498Abstract: The invention relates to an isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them.Type: ApplicationFiled: November 2, 2007Publication date: November 5, 2009Applicant: The University of QueenslandInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe
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Publication number: 20090105129Abstract: The present invention relates generally to methods for inducing, promoting or otherwise facilitating pain relief. More particularly, the present invention relates to a synergistic combination of a selective inhibitor of the neuronal norepinephrine transporter and an analgesic agent in the therapeutic management of vertebrate animals, including humans, for producing analgesia or for the prevention or alleviation of pain.Type: ApplicationFiled: June 22, 2007Publication date: April 23, 2009Applicant: XENOME LTDInventor: Richard James Lewis
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Publication number: 20090088389Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO: 3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not Mr1A, Mr1B, Mar2, CMrV1A, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: ApplicationFiled: October 14, 2008Publication date: April 2, 2009Applicant: XENOME LTD.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Patent number: 7507717Abstract: An isolated, synthetic or recombinant X-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO:3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not MrIA, MrIB, Mar2, CMrVIA, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: GrantFiled: December 2, 2003Date of Patent: March 24, 2009Assignee: Xenome Ltd.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Patent number: 7326682Abstract: The invention relates to an isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them.Type: GrantFiled: August 13, 2004Date of Patent: February 5, 2008Assignee: Xenome LimitedInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe
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Patent number: 7101849Abstract: An isolated, synthetic, or recombinant ?-conotoxin peptide in which the fourth loop between cysteine residues 5 and 6 comprises SEQ ID NO: 1 or such a sequence which has undergone one or more amino acid substitutions or side chain modifications, and uses therefor. SEQ ID NO: 1 comprises the amino acid sequence SGTVGR.Type: GrantFiled: April 16, 1999Date of Patent: September 5, 2006Assignee: The University of QueenslandInventors: Roger Desmond Drinkwater, Richard James Lewis, Paul Francis Alewood, Katherine Justine Nielsen
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Patent number: 6849601Abstract: The present invention relates to novel peptides and derivatives thereof useful as selective ?1-adrenoceptor antagonists which ability of inhibiting the agonist action of agonist noradrenaline on the ?1-adrenoceptor is greater than their ability of inhibiting the action of agonist noradrenaline on the other ?-adrenoceptors. The invention also relates to pharmaceutical compositions comprising these peptides.Type: GrantFiled: October 1, 1999Date of Patent: February 1, 2005Assignee: The University of QueenslandInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe
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Patent number: 6794361Abstract: The invention relates to an isolated, synthetic or recombinant &khgr;-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatment involving them.Type: GrantFiled: June 27, 2001Date of Patent: September 21, 2004Assignee: The University of QueenslandInventors: Richard James Lewis, Paul Francis Alewood, Iain Andrew Sharpe