Abstract: The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.

Abstract: A stator seal for a turbine assembly includes a seal base securable to a turbine stator and including an annular inner surface, and an abradable coating disposed on the annular inner surface. The abradable coating and the annular inner surface have a predefined cross-sectional profile including a transient operation section that facilitates axial expansion and a steady state operation section that facilitates a tighter clearance.

Abstract: Various embodiments include a turbomachine including a swirl-inhibiting seal. In various particular embodiments, a turbomachine includes: a rotor section having sets of axially disposed blades; a diaphragm section at least partially surrounding the rotor section, the diaphragm section including a set of nozzles positioned between adjacent sets of axially disposed blades, wherein the set of nozzles includes at least one nozzle having: a base section coupled to the diaphragm section; a blade coupled to the base section; and a radial tip section coupled to a radial end of the blade, the radial tip section including an axially extending flange having a slot extending therethrough for controlling fluid flow within the turbomachine.

Abstract: Embodiments of the invention relate generally to rotor cooling and, more particularly, to a stator member having at least one passage for the delivery of cooling steam to a bucket root. In one embodiment, the invention provides a turbine comprising: a rotor including a first bucket root; and a stator member having: a rotor bore within which at least a portion of the rotor is disposed; a facing end adjacent to the first bucket root of the rotor; a plurality of seals within the rotor bore for sealing against the rotor, the plurality of seals including a first seal nearest the facing end and a second seal adjacent to the first seal; and a plurality of passages, each extending from a surface of the rotor bore at a point between the first seal and the second seal and extending through the facing end.

Abstract: Embodiments of the invention relate generally to rotor cooling and, more particularly, to a stator member having at least one passage for the delivery of cooling steam to a bucket root. In one embodiment, the invention provides a turbine comprising: a rotor including a first bucket root; and a stator member having: a rotor bore within which at least a portion of the rotor is disposed; a facing end adjacent to the first bucket root of the rotor; a plurality of seals within the rotor bore for sealing against the rotor, the plurality of seals including a first seal nearest the facing end and a second seal adjacent to the first seal; and a plurality of passages, each extending from a surface of the rotor bore at a point between the first seal and the second seal and extending through the facing end.

Abstract: A steam turbine with a drum rotor utilizing individual nozzle ring assemblies in the IP section incased by a single shell. In one embodiment, a steam turbine has a high pressure (HP) section with a double shell drum and an intermediate pressure (IP) section with a single shell drum, with the IP section including a plurality of individual nozzle ring assemblies axially spaced along the single shell casing, such that each nozzle ring assembly surrounds the drum rotor. In other embodiments, a low pressure section (LP) of the steam turbine can have a single-flow or dual-flow connection to a condenser, and the condenser can be positioned to the side, vertically below, or axially aligned with the LP section.

Abstract: Various embodiments include a turbomachine including a swirl-inhibiting seal. In various particular embodiments, a turbomachine includes: a rotor section having sets of axially disposed blades; a diaphragm section at least partially surrounding the rotor section, the diaphragm section including a set of nozzles positioned between adjacent sets of axially disposed blades, wherein the set of nozzles includes at least one nozzle having: a base section coupled to the diaphragm section; a blade coupled to the base section; and a radial tip section coupled to a radial end of the blade, the radial tip section including an axially extending flange having a slot extending therethrough for controlling fluid flow within the turbomachine.

Abstract: A stator seal for a turbine assembly includes a seal base securable to a turbine stator and including an annular inner surface, and an abradable coating disposed on the annular inner surface. The abradable coating and the annular inner surface have a predefined cross-sectional profile including a transient operation section that facilitates axial expansion and a steady state operation section that facilitates a tighter clearance.

Abstract: A steam turbine with a drum rotor utilizing individual nozzle ring assemblies in the IP section incased by a single shell. In one embodiment, a steam turbine has a high pressure (HP) section with a double shell drum and an intermediate pressure (IP) section with a single shell drum, with the IP section including a plurality of individual nozzle ring assemblies axially spaced along the single shell casing, such that each nozzle ring assembly surrounds the drum rotor. In other embodiments, a low pressure section (LP) of the steam turbine can have a single-flow or dual-flow connection to a condenser, and the condenser can be positioned to the side, vertically below, or axially aligned with the LP section.

Abstract: A refrigerator cabinet assembly includes a shell formed by opposed, upright side walls and a top wall, all of which have in-turned front and rear face portions with each of the front face portions terminating in a return flange defining a liner receiving cavity opening forwardly of the shell. Each liner receiving cavity is spaced inwardly of a respective side and top wall such that a channel, which is readily accessible from within the shell, is defined. A rear wall is interconnected to the side and top walls by being arranged between and forced to intimately contact a pair of spaced layers defining the rear face portions of each of these walls. A plurality of reinforcement members, including a pair of upper corner plates and a pair of side reinforcement bars adapted to be arranged in the channel, as well as upper and lower crossbars in one preferred embodiment that interconnect the side reinforcement members, are attached to the shell, along with a mullion plate and a faceplate.

Abstract: A refrigerator cabinet assembly includes a shell formed by opposed, upright side walls and a top wall, all of which have in-turned front and rear face portions with each of the front face portions terminating in a return flange defining a liner receiving cavity opening forwardly of the shell. Each liner receiving cavity is spaced inwardly of a respective side and top wall such that a channel, which is readily accessible from within the shell, is defined. A rear wall is interconnected to the side and top walls by being arranged between and forced to intimately contact a pair of spaced layers defining the rear face portions of each of these walls. A plurality of reinforcement members, including a pair of upper corner plates and a pair of side reinforcement bars adapted to be arranged in the channel, as well as upper and lower crossbars in one preferred embodiment that interconnect the side reinforcement members, are attached to the shell, along with a mullion plate and a faceplate.